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Items: 1 to 20 of 93

1.

RS-WebPredictor: a server for predicting CYP-mediated sites of metabolism on drug-like molecules.

Zaretzki J, Bergeron C, Huang TW, Rydberg P, Swamidass SJ, Breneman CM.

Bioinformatics. 2013 Feb 15;29(4):497-8. doi: 10.1093/bioinformatics/bts705. Epub 2012 Dec 14.

2.

RS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes.

Zaretzki J, Rydberg P, Bergeron C, Bennett KP, Olsen L, Breneman CM.

J Chem Inf Model. 2012 Jun 25;52(6):1637-59. doi: 10.1021/ci300009z. Epub 2012 May 29.

3.

Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities.

Doehmer J, Weiss G, McGregor GP, Appel K.

Toxicol In Vitro. 2011 Feb;25(1):21-7. doi: 10.1016/j.tiv.2010.09.001. Epub 2010 Sep 7.

PMID:
20828605
4.

SOMP: web server for in silico prediction of sites of metabolism for drug-like compounds.

Rudik A, Dmitriev A, Lagunin A, Filimonov D, Poroikov V.

Bioinformatics. 2015 Jun 15;31(12):2046-8. doi: 10.1093/bioinformatics/btv087. Epub 2015 Feb 11.

PMID:
25777527
5.

Metabolism site prediction based on xenobiotic structural formulas and PASS prediction algorithm.

Rudik AV, Dmitriev AV, Lagunin AA, Filimonov DA, Poroikov VV.

J Chem Inf Model. 2014 Feb 24;54(2):498-507. doi: 10.1021/ci400472j. Epub 2014 Jan 17.

PMID:
24417355
6.

Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine.

Wójcikowski J, Pichard-Garcia L, Maurel P, Daniel WA.

Br J Pharmacol. 2003 Apr;138(8):1465-74.

7.

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.

Zanger UM, Schwab M.

Pharmacol Ther. 2013 Apr;138(1):103-41. doi: 10.1016/j.pharmthera.2012.12.007. Epub 2013 Jan 16. Review.

8.

Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.

Mishra NK, Agarwal S, Raghava GP.

BMC Pharmacol. 2010 Jul 16;10:8. doi: 10.1186/1471-2210-10-8.

9.

Identification of human cytochrome P450 isoforms involved in the metabolism of brotizolam.

Senda C, Kishimoto W, Sakai K, Nagakura A, Igarashi T.

Xenobiotica. 1997 Sep;27(9):913-22.

PMID:
9381732
10.
11.
12.

Assessment of drug-drug interaction for silymarin.

Doehmer J, Tewes B, Klein KU, Gritzko K, Muschick H, Mengs U.

Toxicol In Vitro. 2008 Apr;22(3):610-7. doi: 10.1016/j.tiv.2007.11.020. Epub 2007 Dec 8.

PMID:
18249085
13.

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.

Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, Auld DS.

Nat Biotechnol. 2009 Nov;27(11):1050-5. doi: 10.1038/nbt.1581. Epub 2009 Oct 25.

14.

Metabolism of carteolol by cDNA-expressed human cytochrome P450.

Kudo S, Uchida M, Odomi M.

Eur J Clin Pharmacol. 1997;52(6):479-85.

PMID:
9342584
15.

Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus.

Ono S, Tsutsui M, Gonzalez FJ, Satoh T, Masubuchi Y, Horie T, Suzuki T, Narimatsu S.

Pharmacogenetics. 1995 Apr;5(2):97-102.

PMID:
7663534
16.

Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.

Westerink WM, Schoonen WG.

Toxicol In Vitro. 2007 Dec;21(8):1581-91. Epub 2007 Jun 8.

PMID:
17637504
18.

WhichCyp: prediction of cytochromes P450 inhibition.

Rostkowski M, Spjuth O, Rydberg P.

Bioinformatics. 2013 Aug 15;29(16):2051-2. doi: 10.1093/bioinformatics/btt325. Epub 2013 Jun 5.

PMID:
23740742
19.

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver.

Hakkola J, Pasanen M, Purkunen R, Saarikoski S, Pelkonen O, Mäenpää J, Rane A, Raunio H.

Biochem Pharmacol. 1994 Jul 5;48(1):59-64.

PMID:
8043031
20.

The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application.

Wójcikowski J, Basińska A, Daniel WA.

Biochem Pharmacol. 2014 Jul 15;90(2):188-95. doi: 10.1016/j.bcp.2014.05.005. Epub 2014 May 16.

PMID:
24841887

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