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The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation.

Gkountela S, Li Z, Vincent JJ, Zhang KX, Chen A, Pellegrini M, Clark AT.

Nat Cell Biol. 2013 Jan;15(1):113-22. doi: 10.1038/ncb2638. Epub 2012 Dec 16.


Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells.

Vincent JJ, Li Z, Lee SA, Liu X, Etter MO, Diaz-Perez SV, Taylor SK, Gkountela S, Lindgren AG, Clark AT.

PLoS One. 2011;6(12):e28960. doi: 10.1371/journal.pone.0028960. Epub 2011 Dec 15.


Exogenous supplementation of Activin A enhances germ cell differentiation of human embryonic stem cells.

Duggal G, Heindryckx B, Warrier S, Taelman J, Van der Jeught M, Deforce D, Chuva de Sousa Lopes S, De Sutter P.

Mol Hum Reprod. 2015 May;21(5):410-23. doi: 10.1093/molehr/gav004. Epub 2015 Jan 29.


Expression of pluripotent stem cell markers in the human fetal testis.

Kerr CL, Hill CM, Blumenthal PD, Gearhart JD.

Stem Cells. 2008 Feb;26(2):412-21. Epub 2007 Nov 15.


The early human germ cell lineage does not express SOX2 during in vivo development or upon in vitro culture.

Perrett RM, Turnpenny L, Eckert JJ, O'Shea M, Sonne SB, Cameron IT, Wilson DI, Rajpert-De Meyts E, Hanley NA.

Biol Reprod. 2008 May;78(5):852-8. doi: 10.1095/biolreprod.107.066175. Epub 2008 Jan 16.


LIN28 is selectively expressed by primordial and pre-meiotic germ cells in the human fetal ovary.

Childs AJ, Kinnell HL, He J, Anderson RA.

Stem Cells Dev. 2012 Sep 1;21(13):2343-9. doi: 10.1089/scd.2011.0730. Epub 2012 Mar 6.


Forget the Parents: Epigenetic Reprogramming in Human Germ Cells.

von Meyenn F, Reik W.

Cell. 2015 Jun 4;161(6):1248-51. doi: 10.1016/j.cell.2015.05.039.


Humans put their eggs in more than one basket.

Laird DJ.

Nat Cell Biol. 2013 Jan;15(1):13-5. doi: 10.1038/ncb2665. Erratum in: Nat Cell Biol. 2013 Feb;15(2):229.


Epigenetic reprogramming in the porcine germ line.

Hyldig SM, Croxall N, Contreras DA, Thomsen PD, Alberio R.

BMC Dev Biol. 2011 Feb 25;11:11. doi: 10.1186/1471-213X-11-11. Erratum in: BMC Dev Biol. 2011;11. doi:10.1186/1471-213X-11-42.


Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells.

Park TS, Galic Z, Conway AE, Lindgren A, van Handel BJ, Magnusson M, Richter L, Teitell MA, Mikkola HK, Lowry WE, Plath K, Clark AT.

Stem Cells. 2009 Apr;27(4):783-95. doi: 10.1002/stem.13.


In vitro and in vivo differentiation of induced pluripotent stem cells into male germ cells.

Cai H, Xia X, Wang L, Liu Y, He Z, Guo Q, Xu C.

Biochem Biophys Res Commun. 2013 Apr 12;433(3):286-91. doi: 10.1016/j.bbrc.2013.02.107. Epub 2013 Mar 20.


Active DNA demethylation is required for complete imprint erasure in primordial germ cells.

Kawasaki Y, Lee J, Matsuzawa A, Kohda T, Kaneko-Ishino T, Ishino F.

Sci Rep. 2014 Jan 13;4:3658. doi: 10.1038/srep03658.


Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

Popp C, Dean W, Feng S, Cokus SJ, Andrews S, Pellegrini M, Jacobsen SE, Reik W.

Nature. 2010 Feb 25;463(7284):1101-5. doi: 10.1038/nature08829.


BMP signaling in the human fetal ovary is developmentally regulated and promotes primordial germ cell apoptosis.

Childs AJ, Kinnell HL, Collins CS, Hogg K, Bayne RA, Green SJ, McNeilly AS, Anderson RA.

Stem Cells. 2010 Aug;28(8):1368-78. doi: 10.1002/stem.440.


Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA.

Science. 2013 Jan 25;339(6118):448-52. doi: 10.1126/science.1229277. Epub 2012 Dec 6.


Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.

Xu X, Tan X, Lin Q, Schmidt B, Engel W, Pantakani DV.

Biochim Biophys Acta. 2013 May;1829(5):425-35. doi: 10.1016/j.bbagrm.2012.12.010. Epub 2013 Jan 6.


Role of Tet1 in erasure of genomic imprinting.

Yamaguchi S, Shen L, Liu Y, Sendler D, Zhang Y.

Nature. 2013 Dec 19;504(7480):460-4. doi: 10.1038/nature12805. Epub 2013 Dec 1.


Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.

Chen L, Faire M, Kissner MD, Laird DJ.

Hum Mol Genet. 2013 Jan 15;22(2):313-27. doi: 10.1093/hmg/dds430. Epub 2012 Oct 16.

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