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Items: 1 to 20 of 81

1.

The histone methyltransferase MMSET regulates class switch recombination.

Pei H, Wu X, Liu T, Yu K, Jelinek DF, Lou Z.

J Immunol. 2013 Jan 15;190(2):756-63. doi: 10.4049/jimmunol.1201811. Epub 2012 Dec 14.

2.

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites.

Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z.

Nature. 2011 Feb 3;470(7332):124-8. doi: 10.1038/nature09658.

3.

Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage.

Hajdu I, Ciccia A, Lewis SM, Elledge SJ.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13130-4. doi: 10.1073/pnas.1110081108. Epub 2011 Jul 25.

4.

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.

Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, Schwartz RJ, Kaneda Y.

Nature. 2009 Jul 9;460(7252):287-91. doi: 10.1038/nature08086. Epub 2009 May 31.

PMID:
19483677
5.

The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.

Begum NA, Stanlie A, Nakata M, Akiyama H, Honjo T.

J Biol Chem. 2012 Sep 21;287(39):32415-29. Epub 2012 Jul 26.

6.

Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair.

Hsiao KY, Mizzen CA.

J Mol Cell Biol. 2013 Jun;5(3):157-65. doi: 10.1093/jmcb/mjs066. Epub 2013 Jan 16.

PMID:
23329852
7.

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor.

Marango J, Shimoyama M, Nishio H, Meyer JA, Min DJ, Sirulnik A, Martinez-Martinez Y, Chesi M, Bergsagel PL, Zhou MM, Waxman S, Leibovitch BA, Walsh MJ, Licht JD.

Blood. 2008 Mar 15;111(6):3145-54. Epub 2007 Dec 21.

8.

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD.

Blood. 2011 Jan 6;117(1):211-20. doi: 10.1182/blood-2010-07-298349. Epub 2010 Oct 25.

9.

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents.

Shah MY, Martinez-Garcia E, Phillip JM, Chambliss AB, Popovic R, Ezponda T, Small EC, Will C, Phillip MP, Neri P, Bahlis NJ, Wirtz D, Licht JD.

Oncogene. 2016 Nov 10;35(45):5905-5915. doi: 10.1038/onc.2016.116. Epub 2016 Apr 25.

PMID:
27109101
10.

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec Højfeldt M, Vala A, Yang W, López-Méndez B, Lee JE, Peng W, Yuan J, Ge K, Montoya G, Nussenzweig A, Choudhary C, Daniel JA.

Genes Dev. 2016 Jan 15;30(2):149-63. doi: 10.1101/gad.268797.115. Epub 2016 Jan 7.

11.

The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer.

Ezponda T, Popovic R, Shah MY, Martinez-Garcia E, Zheng Y, Min DJ, Will C, Neri A, Kelleher NL, Yu J, Licht JD.

Oncogene. 2013 Jun 6;32(23):2882-90. doi: 10.1038/onc.2012.297. Epub 2012 Jul 16.

12.

Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.

Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10560-E10567. doi: 10.1073/pnas.1701366114. Epub 2017 Nov 20.

PMID:
29158395
13.

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.

Rocha PP, Raviram R, Fu Y, Kim J, Luo VM, Aljoufi A, Swanzey E, Pasquarella A, Balestrini A, Miraldi ER, Bonneau R, Petrini J, Schotta G, Skok JA.

Cell Rep. 2016 Jun 28;16(1):48-55. doi: 10.1016/j.celrep.2016.05.073. Epub 2016 Jun 16.

14.

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.

Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A.

J Exp Med. 2010 May 10;207(5):973-81. doi: 10.1084/jem.20092308. Epub 2010 Apr 12.

15.

The NSD family of protein methyltransferases in human cancer.

Vougiouklakis T, Hamamoto R, Nakamura Y, Saloura V.

Epigenomics. 2015 Aug;7(5):863-74. doi: 10.2217/epi.15.32. Epub 2015 May 5. Review.

PMID:
25942451
16.
17.

Deletions involving genes WHSC1 and LETM1 may be necessary, but are not sufficient to cause Wolf-Hirschhorn Syndrome.

Andersen EF, Carey JC, Earl DL, Corzo D, Suttie M, Hammond P, South ST.

Eur J Hum Genet. 2014 Apr;22(4):464-70. doi: 10.1038/ejhg.2013.192. Epub 2013 Aug 21.

18.

Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.

Toyokawa G, Cho HS, Masuda K, Yamane Y, Yoshimatsu M, Hayami S, Takawa M, Iwai Y, Daigo Y, Tsuchiya E, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, Nakamura Y, Hamamoto R.

Neoplasia. 2011 Oct;13(10):887-98.

19.

AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4.

White CA, Seth Hawkins J, Pone EJ, Yu ES, Al-Qahtani A, Mai T, Zan H, Casali P.

Autoimmunity. 2011 Dec;44(8):585-98. doi: 10.3109/08916934.2011.577128. Epub 2011 May 18. Erratum in: Autoimmunity. 2011 Dec;44(8):664.

20.

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB.

Nat Immunol. 2004 May;5(5):481-7. Epub 2004 Apr 11.

PMID:
15077110

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