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Items: 1 to 20 of 249

1.

IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.

Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, Engel DR, Scheller J, Rose-John S, Mittrücker HW.

J Immunol. 2013 Jan 15;190(2):703-11. doi: 10.4049/jimmunol.1201044. Epub 2012 Dec 12.

2.

Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity.

Lissilaa R, Buatois V, Magistrelli G, Williams AS, Jones GW, Herren S, Shang L, Malinge P, Guilhot F, Chatel L, Hatterer E, Jones SA, Kosco-Vilbois MH, Ferlin WG.

J Immunol. 2010 Nov 1;185(9):5512-21. doi: 10.4049/jimmunol.1002015. Epub 2010 Sep 24.

3.

Mechanism of murine Vgamma1+ gamma delta T cell-mediated innate immune response against Listeria monocytogenes infection.

Matsuzaki G, Yamada H, Kishihara K, Yoshikai Y, Nomoto K.

Eur J Immunol. 2002 Apr;32(4):928-35.

PMID:
11920558
4.

Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis.

Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grötzinger J, Rose-John S, Ehlers S, Hölscher C.

Immunobiology. 2012 Oct;217(10):996-1004. doi: 10.1016/j.imbio.2012.01.015. Epub 2012 Jan 20.

PMID:
22387074
5.

Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice.

Wunderlich CM, Delić D, Behnke K, Meryk A, Ströhle P, Chaurasia B, Al-Quraishy S, Wunderlich F, Brüning JC, Wunderlich FT.

J Immunol. 2012 May 1;188(9):4141-4. doi: 10.4049/jimmunol.1102137. Epub 2012 Mar 30.

6.

Fas-mediated inflammatory response in Listeria monocytogenes infection.

Uchiyama R, Yonehara S, Tsutsui H.

J Immunol. 2013 Apr 15;190(8):4245-54. doi: 10.4049/jimmunol.1203059. Epub 2013 Mar 15.

7.

Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.

Veverka V, Baker T, Redpath NT, Carrington B, Muskett FW, Taylor RJ, Lawson AD, Henry AJ, Carr MD.

J Biol Chem. 2012 Nov 16;287(47):40043-50. doi: 10.1074/jbc.M112.405597. Epub 2012 Oct 1.

8.

Stimulation of the molecule 4-1BB enhances host defense against Listeria monocytogenes infection in mice by inducing rapid infiltration and activation of neutrophils and monocytes.

Lee SC, Ju SA, Sung BH, Heo SK, Cho HR, Lee EA, Kim JD, Lee IH, Park SM, Nguyen QT, Suh JH, Kim BS.

Infect Immun. 2009 May;77(5):2168-76. doi: 10.1128/IAI.01350-08. Epub 2009 Feb 23.

9.

Soluble IL-6 receptor induces calcium flux and selectively modulates chemokine expression in human dermal fibroblasts.

Spörri B, Müller KM, Wiesmann U, Bickel M.

Int Immunol. 1999 Jul;11(7):1053-8.

PMID:
10383937
10.

ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.

Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker HW, Chalaris A.

J Leukoc Biol. 2016 May;99(5):749-60. doi: 10.1189/jlb.3A0515-207R. Epub 2015 Nov 11.

11.

Interleukin-6 and its receptors: a highly regulated and dynamic system.

Wolf J, Rose-John S, Garbers C.

Cytokine. 2014 Nov;70(1):11-20. doi: 10.1016/j.cyto.2014.05.024. Epub 2014 Jun 28. Review.

PMID:
24986424
12.

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J.

J Biol Chem. 2008 Oct 3;283(40):27200-7. doi: 10.1074/jbc.M803694200. Epub 2008 Jul 23.

13.

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.

Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ.

J Immunol. 2011 Jan 15;186(2):1199-208. doi: 10.4049/jimmunol.1002971. Epub 2010 Dec 10.

14.

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.

Rose-John S, Scheller J, Elson G, Jones SA.

J Leukoc Biol. 2006 Aug;80(2):227-36. Epub 2006 May 17. Review.

PMID:
16707558
15.

A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor.

Ancey C, Küster A, Haan S, Herrmann A, Heinrich PC, Müller-Newen G.

J Biol Chem. 2003 May 9;278(19):16968-72. Epub 2003 Mar 19.

16.

The IL-6/sIL-6R complex as a novel target for therapeutic approaches.

Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D.

Expert Opin Ther Targets. 2007 May;11(5):613-24. Review.

PMID:
17465721
17.

IL-17A-producing gammadeltaT cells promote CTL responses against Listeria monocytogenes infection by enhancing dendritic cell cross-presentation.

Xu S, Han Y, Xu X, Bao Y, Zhang M, Cao X.

J Immunol. 2010 Nov 15;185(10):5879-87. doi: 10.4049/jimmunol.1001763. Epub 2010 Oct 18.

18.

Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.

Chalaris A, Schmidt-Arras D, Yamamoto K, Rose-John S.

Dig Dis. 2012;30(5):492-9. doi: 10.1159/000341698. Epub 2012 Oct 24.

PMID:
23108305
19.

Inhibition of interleukin-6-transsignaling via gp130-Fc in hemorrhagic shock and sepsis.

Mees ST, Toellner S, Marx K, Faendrich F, Kallen KJ, Schroeder J, Haier J, Kahlke V.

J Surg Res. 2009 Dec;157(2):235-42. doi: 10.1016/j.jss.2008.08.035. Epub 2008 Sep 29.

PMID:
19589542
20.

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.

Fielding CA, McLoughlin RM, McLeod L, Colmont CS, Najdovska M, Grail D, Ernst M, Jones SA, Topley N, Jenkins BJ.

J Immunol. 2008 Aug 1;181(3):2189-95.

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