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IL-6 is not necessary for the regulation of adipose tissue mitochondrial content.

Wan Z, Perry CG, Macdonald T, Chan CB, Holloway GP, Wright DC.

PLoS One. 2012;7(12):e51233. doi: 10.1371/journal.pone.0051233. Epub 2012 Dec 11.


Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance.

Sutherland LN, Capozzi LC, Turchinsky NJ, Bell RC, Wright DC.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1076-83. doi: 10.1152/ajpendo.90408.2008. Epub 2008 Sep 9.


Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice.

Yamaguchi K, Nishimura T, Ishiba H, Seko Y, Okajima A, Fujii H, Tochiki N, Umemura A, Moriguchi M, Sumida Y, Mitsuyoshi H, Yasui K, Minami M, Okanoue T, Itoh Y.

Liver Int. 2015 Feb;35(2):550-61. doi: 10.1111/liv.12645. Epub 2014 Aug 12.


Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids.

Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li JY, Kraegen EW, Cooney GJ, Ye JM.

Diabetes. 2009 Nov;58(11):2547-54. doi: 10.2337/db09-0784. Epub 2009 Aug 31. Erratum in: Diabetes. 2010 May;59(5):1283.


MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.

Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack CJ, Netea MG, Joosten LA, Stienstra R.

PLoS One. 2014 Feb 24;9(2):e89615. doi: 10.1371/journal.pone.0089615. eCollection 2014.


High-fat diet action on adiposity, inflammation, and insulin sensitivity depends on the control low-fat diet.

Benoit B, Plaisancié P, Awada M, Géloën A, Estienne M, Capel F, Malpuech-Brugère C, Debard C, Pesenti S, Morio B, Vidal H, Rieusset J, Michalski MC.

Nutr Res. 2013 Nov;33(11):952-60. doi: 10.1016/j.nutres.2013.07.017. Epub 2013 Sep 14.


Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease.

Morgan K, Uyuni A, Nandgiri G, Mao L, Castaneda L, Kathirvel E, French SW, Morgan TR.

Eur J Gastroenterol Hepatol. 2008 Sep;20(9):843-54. doi: 10.1097/MEG.0b013e3282f9b203.


Metabolic consequences of ENPP1 overexpression in adipose tissue.

Pan W, Ciociola E, Saraf M, Tumurbaatar B, Tuvdendorj D, Prasad S, Chandalia M, Abate N.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E901-11. doi: 10.1152/ajpendo.00087.2011. Epub 2011 Aug 2.


High-fat diet feeding induces a depot-dependent response on the pro-inflammatory state and mitochondrial function of gonadal white adipose tissue.

Amengual-Cladera E, Lladó I, Proenza AM, Gianotti M.

Br J Nutr. 2013 Feb 14;109(3):413-24. doi: 10.1017/S0007114512001171. Epub 2012 May 1.


12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.

Sears DD, Miles PD, Chapman J, Ofrecio JM, Almazan F, Thapar D, Miller YI.

PLoS One. 2009 Sep 29;4(9):e7250. doi: 10.1371/journal.pone.0007250.


A fish oil diet does not reverse insulin resistance despite decreased adipose tissue TNF-alpha protein concentration in ApoE-3*Leiden mice.

Muurling M, Mensink RP, Pijl H, Romijn JA, Havekes LM, Voshol PJ.

J Nutr. 2003 Nov;133(11):3350-5.


Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.

McGillicuddy FC, Harford KA, Reynolds CM, Oliver E, Claessens M, Mills KH, Roche HM.

Diabetes. 2011 Jun;60(6):1688-98. doi: 10.2337/db10-1278. Epub 2011 Apr 22.


Long-term high-fat diet links the regulation of the insulin-sensitizing fibroblast growth factor-21 and visfatin.

Sun B, Yang G, Yang M, Liu H, Boden G, Li L.

Cytokine. 2012 Jul;59(1):131-7. doi: 10.1016/j.cyto.2012.03.030. Epub 2012 Apr 27.


Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME.

Obesity (Silver Spring). 2008 Jun;16(6):1248-55. doi: 10.1038/oby.2008.210. Epub 2008 Apr 10.


Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice.

Macpherson RE, Huber JS, Frendo-Cumbo S, Simpson JA, Wright DC.

Med Sci Sports Exerc. 2015 Oct;47(10):2034-42. doi: 10.1249/MSS.0000000000000660.


Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.

Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA.

Cell Metab. 2015 Mar 3;21(3):403-16. doi: 10.1016/j.cmet.2015.02.006. Erratum in: Cell Metab. 2016 Mar 8;23(3):563.


Role of PYK2 in the development of obesity and insulin resistance.

Yu Y, Ross SA, Halseth AE, Hollenbach PW, Hill RJ, Gulve EA, Bond BR.

Biochem Biophys Res Commun. 2005 Sep 9;334(4):1085-91.


PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue.

Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O, Seino S.

Cell Metab. 2012 Jan 4;15(1):38-50. doi: 10.1016/j.cmet.2011.12.002.


Insulin sensitivity of adipocytes from inbred mouse strains resistant or sensitive to diet-induced obesity.

Eberhart GP, West DB, Boozer CN, Atkinson RL.

Am J Physiol. 1994 May;266(5 Pt 2):R1423-8.


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