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Items: 1 to 20 of 100

1.

Differentiation of opioid drug effects by hierarchical multi-site phosphorylation.

Just S, Illing S, Trester-Zedlitz M, Lau EK, Kotowski SJ, Miess E, Mann A, Doll C, Trinidad JC, Burlingame AL, von Zastrow M, Schulz S.

Mol Pharmacol. 2013 Mar;83(3):633-9. doi: 10.1124/mol.112.082875. Epub 2012 Dec 13.

2.

Different mechanisms of homologous and heterologous μ-opioid receptor phosphorylation.

Mann A, Illing S, Miess E, Schulz S.

Br J Pharmacol. 2015 Jan;172(2):311-6. doi: 10.1111/bph.12627. Epub 2014 Jul 1. Review.

3.

Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms.

Zhang X, Wang F, Chen X, Chen Y, Ma L.

J Neurochem. 2008 Jul;106(2):781-92. doi: 10.1111/j.1471-4159.2008.05431.x. Epub 2008 Apr 17.

4.

Heterologous regulation of agonist-independent μ-opioid receptor phosphorylation by protein kinase C.

Illing S, Mann A, Schulz S.

Br J Pharmacol. 2014 Mar;171(5):1330-40. doi: 10.1111/bph.12546.

5.

RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons.

Rodríguez-Muñoz M, de la Torre-Madrid E, Gaitán G, Sánchez-Blázquez P, Garzón J.

Cell Signal. 2007 Dec;19(12):2558-71. Epub 2007 Aug 15.

PMID:
17825524
6.
7.

Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A μ-opioid receptor knock-in mice.

Grecksch G, Just S, Pierstorff C, Imhof AK, Glück L, Doll C, Lupp A, Becker A, Koch T, Stumm R, Höllt V, Schulz S.

J Neurosci. 2011 Sep 28;31(39):13890-6. doi: 10.1523/JNEUROSCI.2304-11.2011.

11.

GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.

Moulédous L, Froment C, Dauvillier S, Burlet-Schiltz O, Zajac JM, Mollereau C.

J Biol Chem. 2012 Apr 13;287(16):12736-49. doi: 10.1074/jbc.M111.314617. Epub 2012 Feb 28.

12.

Bradykinin-induced internalization of the human B2 receptor requires phosphorylation of three serine and two threonine residues at its carboxyl tail.

Pizard A, Blaukat A, Müller-Esterl W, Alhenc-Gelas F, Rajerison RM.

J Biol Chem. 1999 Apr 30;274(18):12738-47.

13.

Role of receptor internalization in opioid tolerance and dependence.

Koch T, Höllt V.

Pharmacol Ther. 2008 Feb;117(2):199-206. Epub 2007 Nov 17. Review.

PMID:
18076994
14.

Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins.

Rodríguez-Muñoz M, de la Torre-Madrid E, Sánchez-Blázquez P, Garzón J.

Mol Pain. 2007 Jul 17;3:19.

15.

Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling.

Zhang NR, Planer W, Siuda ER, Zhao HC, Stickler L, Chang SD, Baird MA, Cao YQ, Bruchas MR.

J Biol Chem. 2012 Dec 7;287(50):42019-30. doi: 10.1074/jbc.M112.405696. Epub 2012 Oct 19.

16.

Phosphoproteomic analysis of the mouse brain mu-opioid (MOP) receptor.

Moulédous L, Froment C, Burlet-Schiltz O, Schulz S, Mollereau C.

FEBS Lett. 2015 Aug 19;589(18):2401-8. doi: 10.1016/j.febslet.2015.07.025. Epub 2015 Jul 29.

17.

Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3.

Schulz R, Wehmeyer A, Schulz K.

J Pharmacol Exp Ther. 2002 Feb;300(2):376-84.

18.

EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation.

Chen Y, Long H, Wu Z, Jiang X, Ma L.

Mol Biol Cell. 2008 Jul;19(7):2973-83. doi: 10.1091/mbc.E07-10-1058. Epub 2008 May 7.

19.

G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.

Terman GW, Jin W, Cheong YP, Lowe J, Caron MG, Lefkowitz RJ, Chavkin C.

Br J Pharmacol. 2004 Jan;141(1):55-64. Epub 2003 Dec 8.

20.

Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor.

Murray SR, Evans CJ, von Zastrow M.

J Biol Chem. 1998 Sep 25;273(39):24987-91.

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