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SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen.

Prabagar MG, Do Y, Ryu S, Park JY, Choi HJ, Choi WS, Yun TJ, Moon J, Choi IS, Ko K, Ko K, Young Shin C, Cheong C, Kang YS.

Cell Death Differ. 2013 Apr;20(4):535-45. doi: 10.1038/cdd.2012.160. Epub 2012 Dec 14.


A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.

Kang YS, Do Y, Lee HK, Park SH, Cheong C, Lynch RM, Loeffler JM, Steinman RM, Park CG.

Cell. 2006 Apr 7;125(1):47-58.


Crystallization and preliminary X-ray diffraction studies of the carbohydrate-recognition domain of SIGN-R1, a receptor for microbial polysaccharides and sialylated antibody on splenic marginal zone macrophages.

Silva-Martin N, Schauer JD, Park CG, Hermoso JA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1264-6. doi: 10.1107/S1744309109041992. Epub 2009 Nov 27.


SIGN-R1 and complement factors are involved in the systemic clearance of radiation-induced apoptotic cells in whole-body irradiated mice.

Park JY, Loh S, Cho EH, Choi HJ, Na TY, Nemeno JG, Lee JI, Yoon TJ, Choi IS, Lee M, Lee JS, Kang YS.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):1064-70. doi: 10.1016/j.bbrc.2015.06.059. Epub 2015 Jun 12.


SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran.

Kang YS, Yamazaki S, Iyoda T, Pack M, Bruening SA, Kim JY, Takahara K, Inaba K, Steinman RM, Park CG.

Int Immunol. 2003 Feb;15(2):177-86.


C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide.

Saunders SP, Barlow JL, Walsh CM, Bellsoi A, Smith P, McKenzie AN, Fallon PG.

J Immunol. 2010 Mar 1;184(5):2627-37. doi: 10.4049/jimmunol.0901970. Epub 2010 Feb 3.


The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen.

Kang YS, Kim JY, Bruening SA, Pack M, Charalambous A, Pritsker A, Moran TM, Loeffler JM, Steinman RM, Park CG.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):215-20. Epub 2003 Dec 23.


Prion pathogenesis is unaltered following down-regulation of SIGN-R1.

Bradford BM, Brown KL, Mabbott NA.

Virology. 2016 Oct;497:337-45. doi: 10.1016/j.virol.2016.08.005. Epub 2016 Aug 11.


Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells.

Gullstrand B, Mårtensson U, Sturfelt G, Bengtsson AA, Truedsson L.

Clin Exp Immunol. 2009 May;156(2):303-11. doi: 10.1111/j.1365-2249.2009.03896.x. Epub 2009 Mar 2.


Direct binding of C1q to apoptotic cells and cell blebs induces complement activation.

Nauta AJ, Trouw LA, Daha MR, Tijsma O, Nieuwland R, Schwaeble WJ, Gingras AR, Mantovani A, Hack EC, Roos A.

Eur J Immunol. 2002 Jun;32(6):1726-36.


SIGN-R1, a C-type lectin, binds to Bip/GRP78 and this interaction mediates the regurgitation of T-cell-independent type 2 antigen dextran through the endoplasmic reticulum.

Choi HJ, Choi WS, Park JY, Prabagar MG, Kang KH, Jeon SJ, Park SG, Shin CY, Kang YS.

Immunobiology. 2011 Apr;216(4):437-46. doi: 10.1016/j.imbio.2010.09.006. Epub 2010 Sep 24.


The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae.

Park JY, Choi HJ, Prabagar MG, Choi WS, Kim SJ, Cheong C, Park CG, Chin CY, Kang YS.

Neurosci Lett. 2009 Feb 6;450(3):246-51. doi: 10.1016/j.neulet.2008.11.070. Epub 2008 Dec 10.


Marginal zone B cells regulate antigen capture by marginal zone macrophages.

You Y, Myers RC, Freeberg L, Foote J, Kearney JF, Justement LB, Carter RH.

J Immunol. 2011 Feb 15;186(4):2172-81. doi: 10.4049/jimmunol.1002106. Epub 2011 Jan 21.


Spleen deposition of Cryptococcus neoformans capsular glucuronoxylomannan in rodents occurs in red pulp macrophages and not marginal zone macrophages expressing the C-type lectin SIGN-R1.

De Jesus M, Park CG, Su Y, Goldman DL, Steinman RM, Casadevall A.

Med Mycol. 2008 Mar;46(2):153-62. doi: 10.1080/13693780701747182.


C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.

Fraser DA, Laust AK, Nelson EL, Tenner AJ.

J Immunol. 2009 Nov 15;183(10):6175-85. doi: 10.4049/jimmunol.0902232. Epub 2009 Oct 28.


Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction.

Granelli-Piperno A, Pritsker A, Pack M, Shimeliovich I, Arrighi JF, Park CG, Trumpfheller C, Piguet V, Moran TM, Steinman RM.

J Immunol. 2005 Oct 1;175(7):4265-73.


Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.

Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ, Botto M.

J Immunol. 2004 Mar 15;172(6):3406-14.


Structural basis for selective recognition of endogenous and microbial polysaccharides by macrophage receptor SIGN-R1.

Silva-Martín N, Bartual SG, Ramírez-Aportela E, Chacón P, Park CG, Hermoso JA.

Structure. 2014 Nov 4;22(11):1595-606.


IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo.

Ogden CA, Kowalewski R, Peng Y, Montenegro V, Elkon KB.

Autoimmunity. 2005 Jun;38(4):259-64.


DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

Hosszu KK, Valentino A, Vinayagasundaram U, Vinayagasundaram R, Joyce MG, Ji Y, Peerschke EI, Ghebrehiwet B.

Blood. 2012 Aug 9;120(6):1228-36. doi: 10.1182/blood-2011-07-369728. Epub 2012 Jun 13.

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