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Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets.

Tu Z, Keller MP, Zhang C, Rabaglia ME, Greenawalt DM, Yang X, Wang IM, Dai H, Bruss MD, Lum PY, Zhou YP, Kemp DM, Kendziorski C, Yandell BS, Attie AD, Schadt EE, Zhu J.

PLoS Genet. 2012;8(12):e1003107. doi: 10.1371/journal.pgen.1003107. Epub 2012 Dec 6.


Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion.

Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, Truchan NA, Worzella SL, Stoehr JP, Clee SM, Yandell BS, Keller MP, Thurmond DC, Attie AD.

PLoS Genet. 2011 Oct;7(10):e1002323. doi: 10.1371/journal.pgen.1002323. Epub 2011 Oct 6.


Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice.

Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW.

Exp Clin Endocrinol Diabetes. 2013 Jul;121(7):413-9. doi: 10.1055/s-0033-1347249. Epub 2013 Jul 9.


Amyloid precursor protein in pancreatic islets.

Kulas JA, Puig KL, Combs CK.

J Endocrinol. 2017 Oct;235(1):49-67. doi: 10.1530/JOE-17-0122. Epub 2017 Jul 14.


Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice.

Zhao E, Keller MP, Rabaglia ME, Oler AT, Stapleton DS, Schueler KL, Neto EC, Moon JY, Wang P, Wang IM, Lum PY, Ivanovska I, Cleary M, Greenawalt D, Tsang J, Choi YJ, Kleinhanz R, Shang J, Zhou YP, Howard AD, Zhang BB, Kendziorski C, Thornberry NA, Yandell BS, Schadt EE, Attie AD.

Mamm Genome. 2009 Aug;20(8):476-85. doi: 10.1007/s00335-009-9217-2.


Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility.

Lan H, Rabaglia ME, Stoehr JP, Nadler ST, Schueler KL, Zou F, Yandell BS, Attie AD.

Diabetes. 2003 Mar;52(3):688-700.


Abnormally decreased NO and augmented CO production in islets of the leptin-deficient ob/ob mouse might contribute to explain hyperinsulinemia and islet survival in leptin-resistant type 2 obese diabetes.

Jimenez-Feltstrom J, Salehi A, Meidute Abaraviciene S, Henningsson R, Lundquist I.

Regul Pept. 2011 Oct 10;170(1-3):43-51. doi: 10.1016/j.regpep.2011.04.011. Epub 2011 May 26.


Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice.

Flowers JB, Rabaglia ME, Schueler KL, Flowers MT, Lan H, Keller MP, Ntambi JM, Attie AD.

Diabetes. 2007 May;56(5):1228-39. Epub 2007 Mar 16.


Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes.

Chan JY, Luzuriaga J, Bensellam M, Biden TJ, Laybutt DR.

Diabetes. 2013 May;62(5):1557-68. doi: 10.2337/db12-0701. Epub 2012 Dec 28.


Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.

Rabaglia ME, Gray-Keller MP, Frey BL, Shortreed MR, Smith LM, Attie AD.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E218-24. Epub 2005 Mar 1.


Does leptin regulate insulin secretion?

Poitout V, Rouault C, Guerre-Millo M, Reach G.

Diabetes Metab. 1998 Sep;24(4):321-6. Review.


Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.

Stoehr JP, Nadler ST, Schueler KL, Rabaglia ME, Yandell BS, Metz SA, Attie AD.

Diabetes. 2000 Nov;49(11):1946-54.


Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus.

Oh E, Stull ND, Mirmira RG, Thurmond DC.

J Clin Endocrinol Metab. 2014 May;99(5):E866-70. doi: 10.1210/jc.2013-2221. Epub 2014 Feb 19.


The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.

Keller MP, Paul PK, Rabaglia ME, Stapleton DS, Schueler KL, Broman AT, Ye SI, Leng N, Brandon CJ, Neto EC, Plaisier CL, Simonett SP, Kebede MA, Sheynkman GM, Klein MA, Baliga NS, Smith LM, Broman KW, Yandell BS, Kendziorski C, Attie AD.

PLoS Genet. 2016 Dec 9;12(12):e1006466. doi: 10.1371/journal.pgen.1006466. eCollection 2016 Dec.


Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion.

Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M.

Diabetes. 1997 Feb;46(2):313-6.


A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility.

Keller MP, Choi Y, Wang P, Davis DB, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS, Kendziorski C, Attie AD.

Genome Res. 2008 May;18(5):706-16. doi: 10.1101/gr.074914.107. Epub 2008 Mar 17.

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