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Fructose acutely stimulates NHE3 activity in kidney proximal tubule.

Queiroz-Leite GD, Crajoinas RO, Neri EA, Bezerra CN, Girardi AC, Rebouças NA, Malnic G.

Kidney Blood Press Res. 2012;36(1):320-34. doi: 10.1159/000343390. Epub 2012 Dec 12.


Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule.

Lessa LM, Carraro-Lacroix LR, Crajoinas RO, Bezerra CN, Dariolli R, Girardi AC, Fonteles MC, Malnic G.

Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1399-408. doi: 10.1152/ajprenal.00385.2011. Epub 2012 Sep 5.


Renal nerve stimulation leads to the activation of the Na+/H+ exchanger isoform 3 via angiotensin II type I receptor.

Pontes RB, Crajoinas RO, Nishi EE, Oliveira-Sales EB, Girardi AC, Campos RR, Bergamaschi CT.

Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F848-56. doi: 10.1152/ajprenal.00515.2014. Epub 2015 Feb 4.


Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failure.

Inoue BH, dos Santos L, Pessoa TD, Antonio EL, Pacheco BP, Savignano FA, Carraro-Lacroix LR, Tucci PJ, Malnic G, Girardi AC.

Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R166-74. doi: 10.1152/ajpregu.00127.2011. Epub 2011 Oct 26.


Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells.

Carraro-Lacroix LR, Malnic G, Girardi AC.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1647-55. doi: 10.1152/ajprenal.00082.2009. Epub 2009 Sep 23.


Changes in the activity and expression of protein phosphatase-1 accompany the differential regulation of NHE3 before and after the onset of hypertension in spontaneously hypertensive rats.

Crajoinas RO, Pessoa TD, Rodrigues MV, Malnic G, Girardi AC.

Acta Physiol (Oxf). 2014 Jun;211(2):395-408. doi: 10.1111/apha.12288. Epub 2014 Apr 23.


Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule.

Pessoa TD, Campos LC, Carraro-Lacroix L, Girardi AC, Malnic G.

J Am Soc Nephrol. 2014 Sep;25(9):2028-39. doi: 10.1681/ASN.2013060588. Epub 2014 Mar 20.


Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways.

Arnaud-Batista FJ, Peruchetti DB, Abreu TP, do Nascimento NR, Malnic G, Fonteles MC, Caruso-Neves C.

Biochim Biophys Acta. 2016 Jul;1860(7):1431-8. doi: 10.1016/j.bbagen.2016.04.012. Epub 2016 Apr 19.


Dipeptidyl peptidase IV inhibition downregulates Na+ - H+ exchanger NHE3 in rat renal proximal tubule.

Girardi AC, Fukuda LE, Rossoni LV, Malnic G, Rebouças NA.

Am J Physiol Renal Physiol. 2008 Feb;294(2):F414-22. Epub 2007 Dec 12.


The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3.

Lamprecht G, Weinman EJ, Yun CH.

J Biol Chem. 1998 Nov 6;273(45):29972-8.


Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC).

Honegger KJ, Capuano P, Winter C, Bacic D, Stange G, Wagner CA, Biber J, Murer H, Hernando N.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):803-8. Epub 2006 Jan 9. Erratum in: Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4328.


Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells.

Girardi AC, Knauf F, Demuth HU, Aronson PS.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1238-45. Epub 2004 Jun 22.


Posttranslational mechanisms associated with reduced NHE3 activity in adult vs. young prehypertensive SHR.

Crajoinas RO, Lessa LM, Carraro-Lacroix LR, Davel AP, Pacheco BP, Rossoni LV, Malnic G, Girardi AC.

Am J Physiol Renal Physiol. 2010 Oct;299(4):F872-81. doi: 10.1152/ajprenal.00654.2009. Epub 2010 Jul 14.


Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC).

Drumm K, Kress TR, Gassner B, Krug AW, Gekle M.

Cell Physiol Biochem. 2006;17(1-2):21-8. Epub 2006 Feb 7.


Nitric oxide stimulates guanylate cyclase and regulates sodium transport in rabbit proximal tubule.

Roczniak A, Burns KD.

Am J Physiol. 1996 Jan;270(1 Pt 2):F106-15.


NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo.

Gekle M, Völker K, Mildenberger S, Freudinger R, Shull GE, Wiemann M.

Am J Physiol Renal Physiol. 2004 Sep;287(3):F469-73. Epub 2004 Apr 27.


Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling.

Carneiro de Morais CP, Polidoro JZ, Ralph DL, Pessoa TD, Oliveira-Souza M, Barauna VG, Rebouças NA, Malnic G, McDonough AA, Girardi AC.

Am J Physiol Cell Physiol. 2015 Oct 15;309(8):C541-50. doi: 10.1152/ajpcell.00072.2015. Epub 2015 Aug 5.

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