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Items: 1 to 20 of 150

1.

Laquinimod prevents inflammation-induced synaptic alterations occurring in experimental autoimmune encephalomyelitis.

Ruffini F, Rossi S, Bergamaschi A, Brambilla E, Finardi A, Motta C, Studer V, Barbieri F, De Chiara V, Hayardeny L, Comi G, Centonze D, Martino G.

Mult Scler. 2013 Jul;19(8):1084-94. doi: 10.1177/1352458512469698. Epub 2012 Dec 11.

PMID:
23232603
2.

Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor.

Thöne J, Ellrichmann G, Seubert S, Peruga I, Lee DH, Conrad R, Hayardeny L, Comi G, Wiese S, Linker RA, Gold R.

Am J Pathol. 2012 Jan;180(1):267-74. doi: 10.1016/j.ajpath.2011.09.037. Epub 2011 Dec 5.

PMID:
22152994
3.

Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis.

Musumeci G, Grasselli G, Rossi S, De Chiara V, Musella A, Motta C, Studer V, Bernardi G, Haji N, Sepman H, Fresegna D, Maccarrone M, Mandolesi G, Centonze D.

Neurobiol Dis. 2011 Sep;43(3):669-77. doi: 10.1016/j.nbd.2011.05.018. Epub 2011 Jun 6.

PMID:
21672630
4.

Insight into the mechanism of laquinimod action.

Brück W, Wegner C.

J Neurol Sci. 2011 Jul 15;306(1-2):173-9. doi: 10.1016/j.jns.2011.02.019. Epub 2011 Mar 22.

PMID:
21429524
5.

Distinct pathological patterns in relapsing-remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate.

Aharoni R, Vainshtein A, Stock A, Eilam R, From R, Shinder V, Arnon R.

J Autoimmun. 2011 Nov;37(3):228-41. doi: 10.1016/j.jaut.2011.06.003. Epub 2011 Jul 14.

PMID:
21752599
6.

Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis.

Gentile A, Musella A, Bullitta S, Fresegna D, De Vito F, Fantozzi R, Piras E, Gargano F, Borsellino G, Battistini L, Schubart A, Mandolesi G, Centonze D.

J Neuroinflammation. 2016 Aug 26;13(1):207. doi: 10.1186/s12974-016-0686-4.

7.

Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis.

Wegner C, Stadelmann C, Pförtner R, Raymond E, Feigelson S, Alon R, Timan B, Hayardeny L, Brück W.

J Neuroimmunol. 2010 Oct 8;227(1-2):133-43. doi: 10.1016/j.jneuroim.2010.07.009. Epub 2010 Aug 3.

PMID:
20684995
8.

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS.

Parodi B, Rossi S, Morando S, Cordano C, Bragoni A, Motta C, Usai C, Wipke BT, Scannevin RH, Mancardi GL, Centonze D, Kerlero de Rosbo N, Uccelli A.

Acta Neuropathol. 2015 Aug;130(2):279-95. doi: 10.1007/s00401-015-1422-3. Epub 2015 Apr 29.

9.

Glatiramer acetate protects against inflammatory synaptopathy in experimental autoimmune encephalomyelitis.

Gentile A, Rossi S, Studer V, Motta C, De Chiara V, Musella A, Sepman H, Fresegna D, Musumeci G, Grasselli G, Haji N, Weiss S, Hayardeny L, Mandolesi G, Centonze D.

J Neuroimmune Pharmacol. 2013 Jun;8(3):651-63. doi: 10.1007/s11481-013-9436-x. Epub 2013 Jan 31.

PMID:
23370991
10.

Lentivirus-mediated estrogen receptor α overexpression in the central nervous system ameliorates experimental autoimmune encephalomyelitis in mice.

Hu X, Qin X.

Int J Mol Med. 2013 May;31(5):1209-21. doi: 10.3892/ijmm.2013.1306. Epub 2013 Mar 15.

PMID:
23525227
11.

miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation.

Mandolesi G, De Vito F, Musella A, Gentile A, Bullitta S, Fresegna D, Sepman H, Di Sanza C, Haji N, Mori F, Buttari F, Perlas E, Ciotti MT, Hornstein E, Bozzoni I, Presutti C, Centonze D.

J Neurosci. 2017 Jan 18;37(3):546-561. doi: 10.1523/JNEUROSCI.0851-16.2016.

12.

Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis.

Aharoni R, Saada R, Eilam R, Hayardeny L, Sela M, Arnon R.

J Neuroimmunol. 2012 Oct 15;251(1-2):14-24. doi: 10.1016/j.jneuroim.2012.06.005. Epub 2012 Jun 28.

PMID:
22749337
13.

Kinetics of proinflammatory monocytes in a model of multiple sclerosis and its perturbation by laquinimod.

Mishra MK, Wang J, Silva C, Mack M, Yong VW.

Am J Pathol. 2012 Aug;181(2):642-51. doi: 10.1016/j.ajpath.2012.05.011. Epub 2012 Jun 26.

PMID:
22749771
14.

Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions.

Pifarré P, Gutierrez-Mecinas M, Prado J, Usero L, Roura-Mir C, Giralt M, Hidalgo J, García A.

Exp Neurol. 2014 Jan;251:58-71. doi: 10.1016/j.expneurol.2013.10.021. Epub 2013 Nov 7.

PMID:
24211383
15.

Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis.

Jolivel V, Luessi F, Masri J, Kraus SH, Hubo M, Poisa-Beiro L, Klebow S, Paterka M, Yogev N, Tumani H, Furlan R, Siffrin V, Jonuleit H, Zipp F, Waisman A.

Brain. 2013 Apr;136(Pt 4):1048-66. doi: 10.1093/brain/awt023. Epub 2013 Mar 20.

PMID:
23518712
16.

Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.

Schulze-Topphoff U, Shetty A, Varrin-Doyer M, Molnarfi N, Sagan SA, Sobel RA, Nelson PA, Zamvil SS.

PLoS One. 2012;7(3):e33797. doi: 10.1371/journal.pone.0033797. Epub 2012 Mar 30.

17.

Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis.

Centonze D, Muzio L, Rossi S, Cavasinni F, De Chiara V, Bergami A, Musella A, D'Amelio M, Cavallucci V, Martorana A, Bergamaschi A, Cencioni MT, Diamantini A, Butti E, Comi G, Bernardi G, Cecconi F, Battistini L, Furlan R, Martino G.

J Neurosci. 2009 Mar 18;29(11):3442-52. doi: 10.1523/JNEUROSCI.5804-08.2009.

18.

Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis.

Kanwar JR, Kanwar RK, Krissansen GW.

Brain. 2004 Jun;127(Pt 6):1313-31. Epub 2004 May 6.

PMID:
15130951
19.

An electrophysiologic approach to quantify impaired synaptic transmission and plasticity in experimental autoimmune encephalomyelitis.

Prochnow N, Gold R, Haghikia A.

J Neuroimmunol. 2013 Nov 15;264(1-2):48-53. doi: 10.1016/j.jneuroim.2013.09.012. Epub 2013 Sep 20.

PMID:
24090654
20.

Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis.

Rossi S, Muzio L, De Chiara V, Grasselli G, Musella A, Musumeci G, Mandolesi G, De Ceglia R, Maida S, Biffi E, Pedrocchi A, Menegon A, Bernardi G, Furlan R, Martino G, Centonze D.

Brain Behav Immun. 2011 Jul;25(5):947-56. doi: 10.1016/j.bbi.2010.10.004. Epub 2010 Oct 20.

PMID:
20940040

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