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Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.

Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis C.

Mol Pharmacol. 2013 Mar;83(3):594-604. doi: 10.1124/mol.112.081810. Epub 2012 Dec 10.


Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells.

Kim KS, Kang KW, Seu YB, Baek SH, Kim JR.

Mech Ageing Dev. 2009 Mar;130(3):179-88. doi: 10.1016/j.mad.2008.11.004. Epub 2008 Nov 21.


A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4.

Evstafieva AG, Garaeva AA, Khutornenko AA, Klepikova AV, Logacheva MD, Penin AA, Novakovsky GE, Kovaleva IE, Chumakov PM.

Cell Death Dis. 2014 Nov 6;5:e1511. doi: 10.1038/cddis.2014.469.


Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin.

Shi Y, Felley-Bosco E, Marti TM, Orlowski K, Pruschy M, Stahel RA.

BMC Cancer. 2012 Dec 4;12:571. doi: 10.1186/1471-2407-12-571.


ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.

Kline CL, Van den Heuvel AP, Allen JE, Prabhu VV, Dicker DT, El-Deiry WS.

Sci Signal. 2016 Feb 16;9(415):ra18. doi: 10.1126/scisignal.aac4374.


Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells.

Moh MC, Zhang T, Lee LH, Shen S.

Carcinogenesis. 2008 Dec;29(12):2298-305. doi: 10.1093/carcin/bgn226. Epub 2008 Oct 8.


p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization.

Fox DK, Ebert SM, Bongers KS, Dyle MC, Bullard SA, Dierdorff JM, Kunkel SD, Adams CM.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E245-61. doi: 10.1152/ajpendo.00010.2014. Epub 2014 Jun 3.


E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells.

Li Y, Shao J, Shen K, Xu Y, Liu J, Qian X.

J Cell Biochem. 2012 Oct;113(10):3165-77. doi: 10.1002/jcb.24194.


Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence.

Alsayegh KN, Gadepalli VS, Iyer S, Rao RR.

PLoS One. 2015 Mar 18;10(3):e0120782. doi: 10.1371/journal.pone.0120782. eCollection 2015.


Beryllium sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types.

Gorjala P, Gary RK.

Biometals. 2010 Dec;23(6):1061-73. doi: 10.1007/s10534-010-9352-y. Epub 2010 Jun 12.


Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells.

Chiu SJ, Lee YJ, Hsu TS, Chen WS.

Chem Biol Interact. 2009 Dec 10;182(2-3):173-82. doi: 10.1016/j.cbi.2009.08.019. Epub 2009 Sep 6.


58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.

Hsu CC, Lee YC, Yeh SH, Chen CH, Wu CC, Wang TY, Chen YN, Hung LY, Liu YW, Chen HK, Hsiao YT, Wang WS, Tsou JH, Tsou YH, Wu MH, Chang WC, Lin DY.

J Biol Chem. 2012 Jun 29;287(27):22533-48. doi: 10.1074/jbc.M111.335331. Epub 2012 May 4.


Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs.

Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J, Roninson IB.

Oncogene. 1999 Aug 26;18(34):4808-18.


Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro.

Zhang D, Cui Y, Shen H, Xing L, Cui J, Wang J, Zhang X.

PLoS One. 2013 May 21;8(5):e65044. doi: 10.1371/journal.pone.0065044. Print 2013.


p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL, Janic A, Strasser A.

Cell Rep. 2013 May 30;3(5):1339-45. doi: 10.1016/j.celrep.2013.04.012. Epub 2013 May 9.


Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells.

Cho JH, Lee JG, Yang YI, Kim JH, Ahn JH, Baek NI, Lee KT, Choi JH.

Food Chem Toxicol. 2011 Aug;49(8):1737-44. doi: 10.1016/j.fct.2011.04.019. Epub 2011 Apr 29.


TPA-induced p21 expression augments G2/M arrest through a p53-independent mechanism in human breast cancer cells.

Han J, Kim S, Yang JH, Nam SJ, Lee JE.

Oncol Rep. 2012 Feb;27(2):517-22. doi: 10.3892/or.2011.1511. Epub 2011 Oct 20.


c-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage.

Udden SM, Morita-Fujimura Y, Satake M, Ikawa S.

Cell Signal. 2014 Feb;26(2):444-52. doi: 10.1016/j.cellsig.2013.10.005. Epub 2013 Oct 28.


Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors.

Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.

Cancer Res. 2012 Jan 15;72(2):395-401. doi: 10.1158/0008-5472.CAN-11-1891. Epub 2011 Nov 18.

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