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Items: 1 to 20 of 99

1.

Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT(2)-selective melatonin agonists: improving metabolic stability.

Hu Y, Zhu J, Chan KH, Wong YH.

Bioorg Med Chem. 2013 Jan 15;21(2):547-52. doi: 10.1016/j.bmc.2012.10.060.

PMID:
23228808
2.

Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands.

Hu Y, Ho MK, Chan KH, New DC, Wong YH.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. doi: 10.1016/j.bmcl.2010.02.084.

PMID:
20227878
3.

Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands.

Li G, Zhou H, Jiang Y, Keim H, Topiol SW, Poda SB, Ren Y, Chandrasena G, Doller D.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1236-42. doi: 10.1016/j.bmcl.2010.12.068.

PMID:
21237644
4.

Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors.

Carocci A, Catalano A, Lovece A, Lentini G, Duranti A, Lucini V, Pannacci M, Scaglione F, Franchini C.

Bioorg Med Chem. 2010 Sep 1;18(17):6496-511. doi: 10.1016/j.bmc.2010.06.100.

PMID:
20674373
5.

N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands.

Rivara S, Lodola A, Mor M, Bedini A, Spadoni G, Lucini V, Pannacci M, Fraschini F, Scaglione F, Sanchez RO, Gobbi G, Tarzia G.

J Med Chem. 2007 Dec 27;50(26):6618-26.

PMID:
18052314
6.

N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands.

Rivara S, Vacondio F, Fioni A, Silva C, Carmi C, Mor M, Lucini V, Pannacci M, Caronno A, Scaglione F, Gobbi G, Spadoni G, Bedini A, Orlando P, Lucarini S, Tarzia G.

ChemMedChem. 2009 Oct;4(10):1746-55. doi: 10.1002/cmdc.200900240.

PMID:
19728346
7.
8.

Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists.

Jeanty M, Suzenet F, Delagrange P, Nosjean O, Boutin JA, Caignard DH, Guillaumet G.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2316-9. doi: 10.1016/j.bmcl.2011.02.097.

PMID:
21420861
9.

Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands.

Markl C, Attia MI, Julius J, Sethi S, Witt-Enderby PA, Zlotos DP.

Bioorg Med Chem. 2009 Jul 1;17(13):4583-94. doi: 10.1016/j.bmc.2009.04.068.

PMID:
19473848
10.

N-Acetyl-5-arylalkoxytryptamine analogs: probing the melatonin receptors for MT(1) -selectivity.

Markl C, Clafshenkel WP, Attia MI, Sethi S, Witt-Enderby PA, Zlotos DP.

Arch Pharm (Weinheim). 2011 Oct;344(10):666-74. doi: 10.1002/ardp.201100125.

PMID:
21887801
11.

Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands.

Bedini A, Spadoni G, Gatti G, Lucarini S, Tarzia G, Rivara S, Lorenzi S, Lodola A, Mor M, Lucini V, Pannacci M, Scaglione F.

J Med Chem. 2006 Dec 14;49(25):7393-403.

PMID:
17149869
12.

Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines.

Spadoni G, Bedini A, Lucarini S, Mari M, Caignard DH, Boutin JA, Delagrange P, Lucini V, Scaglione F, Lodola A, Zanardi F, Pala D, Mor M, Rivara S.

J Med Chem. 2015 Sep 24;58(18):7512-25. doi: 10.1021/acs.jmedchem.5b01066.

PMID:
26334942
13.

MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides.

Rivara S, Pala D, Lodola A, Mor M, Lucini V, Dugnani S, Scaglione F, Bedini A, Lucarini S, Tarzia G, Spadoni G.

ChemMedChem. 2012 Nov;7(11):1954-64. doi: 10.1002/cmdc.201200303.

PMID:
22927210
14.

N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II.

Carocci A, Catalano A, Bruno C, Lovece A, Roselli MG, Cavalluzzi MM, De Santis F, De Palma A, Rusciano MR, Illario M, Franchini C, Lentini G.

Bioorg Med Chem. 2013 Feb 15;21(4):847-51. doi: 10.1016/j.bmc.2012.12.017.

PMID:
23332368
15.

New melatonin (MT1/MT2) ligands: design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives.

Landagaray E, Ettaoussi M, Leclerc V, Traoré B, Perez V, Nosjean O, Boutin JA, Caignard DH, Delagrange P, Berthelot P, Yous S.

Bioorg Med Chem. 2014 Feb 1;22(3):986-96. doi: 10.1016/j.bmc.2013.12.054.

PMID:
24417958
16.

Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands.

Hu Y, Chan KH, He X, Ho MK, Wong YH.

PLoS One. 2014 Dec 5;9(12):e113638. doi: 10.1371/journal.pone.0113638.

17.

Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).

Ettaoussi M, Sabaouni A, Rami M, Boutin JA, Delagrange P, Renard P, Spedding M, Caignard DH, Berthelot P, Yous S.

Eur J Med Chem. 2012 Mar;49:310-23. doi: 10.1016/j.ejmech.2012.01.027.

PMID:
22301214
18.

Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives.

Landagaray E, Ettaoussi M, Duroux R, Boutin JA, Caignard DH, Delagrange P, Melnyk P, Berthelot P, Yous S.

Eur J Med Chem. 2016 Feb 15;109:360-70. doi: 10.1016/j.ejmech.2015.12.047.

PMID:
26820449
19.

Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.

Lucini V, Pannacci M, Scaglione F, Fraschini F, Rivara S, Mor M, Bordi F, Plazzi PV, Spadoni G, Bedini A, Piersanti G, Diamantini G, Tarzia G.

J Med Chem. 2004 Aug 12;47(17):4202-12.

PMID:
15293992
20.

Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist.

Kato K, Hirai K, Nishiyama K, Uchikawa O, Fukatsu K, Ohkawa S, Kawamata Y, Hinuma S, Miyamoto M.

Neuropharmacology. 2005 Feb;48(2):301-10.

PMID:
15695169
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