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Items: 1 to 20 of 94

1.

Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid.

Jia Y, Kim JY, Jun HJ, Kim SJ, Lee JH, Hoang MH, Kim HS, Chang HI, Hwang KY, Um SJ, Lee SJ.

Biochim Biophys Acta. 2013 Apr;1831(4):698-708. doi: 10.1016/j.bbalip.2012.11.012. Epub 2012 Dec 8.

PMID:
23228689
2.

The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes.

Jia Y, Kim JY, Jun HJ, Kim SJ, Lee JH, Hoang MH, Hwang KY, Um SJ, Chang HI, Lee SJ.

Mol Nutr Food Res. 2012 Jun;56(6):878-88. doi: 10.1002/mnfr.201100798.

PMID:
22707263
3.

Ombuin-3-O-β-D-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors α and δ/β.

Malek MA, Hoang MH, Jia Y, Lee JH, Jun HJ, Lee DH, Lee HJ, Lee C, Lee MK, Hwang BY, Lee SJ.

Biochem Biophys Res Commun. 2013 Jan 25;430(4):1322-8. doi: 10.1016/j.bbrc.2012.12.020. Epub 2012 Dec 13.

PMID:
23247028
4.

Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes.

Jia Y, Hoang MH, Jun HJ, Lee JH, Lee SJ.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4185-90. doi: 10.1016/j.bmcl.2013.05.030. Epub 2013 May 18.

PMID:
23769638
5.

Catalposide is a natural agonistic ligand of peroxisome proliferator-activated receptor-α.

Lee JH, Jun HJ, Hoang MH, Jia Y, Han XH, Lee DH, Lee HJ, Hwang BY, Lee SJ.

Biochem Biophys Res Commun. 2012 Jun 15;422(4):568-72. doi: 10.1016/j.bbrc.2012.05.025. Epub 2012 May 11.

PMID:
22583896
6.

The dipeptide H-Trp-Arg-OH (WR) Is a PPARα agonist and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.

Jia Y, Kim JH, Nam B, Kim J, Lee JH, Kim KO, Hwang KY, Lee SJ.

Appl Biochem Biotechnol. 2015 Jan;175(2):1211-20. doi: 10.1007/s12010-014-1302-7. Epub 2014 Nov 7.

PMID:
25377249
7.

Squalene isolated from Schizochytrium mangrovei is a peroxisome proliferator-activated receptor-α agonist that regulates lipid metabolism in HepG2 cells.

Hoang TM, Nguyen CH, Le TT, Hoang TH, Ngo TH, Hoang TL, Dang DH.

Biotechnol Lett. 2016 Jul;38(7):1065-71. doi: 10.1007/s10529-016-2071-x. Epub 2016 Mar 8.

PMID:
26956235
8.

Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism.

Jia Y, Bhuiyan MJ, Jun HJ, Lee JH, Hoang MH, Lee HJ, Kim N, Lee D, Hwang KY, Hwang BY, Choi DW, Lee SJ.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5876-80. doi: 10.1016/j.bmcl.2011.07.095. Epub 2011 Aug 3.

PMID:
21855333
10.

The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-α and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.

Jia Y, Kim JH, Nam B, Kim J, Lee JH, Hwang KY, Lee SJ.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2957-62. doi: 10.1016/j.bmcl.2014.04.019. Epub 2014 Apr 13.

PMID:
24821375
11.

Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices.

Szalowska E, van der Burg B, Man HY, Hendriksen PJ, Peijnenburg AA.

PLoS One. 2014 Jan 29;9(1):e86795. doi: 10.1371/journal.pone.0086795. eCollection 2014.

12.

Picrasidine N Is a Subtype-Selective PPARβ/δ Agonist.

Zhao S, Kanno Y, Li W, Wakatabi H, Sasaki T, Koike K, Nemoto K, Li H.

J Nat Prod. 2016 Apr 22;79(4):879-85. doi: 10.1021/acs.jnatprod.5b00909. Epub 2016 Mar 30.

PMID:
27025413
13.

C333H, a novel PPARalpha/gamma dual agonist, has beneficial effects on insulin resistance and lipid metabolism.

Xu C, Wang LL, Liu HY, Zhou XB, Cao YL, Li S.

Acta Pharmacol Sin. 2006 Feb;27(2):223-8.

14.

A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma.

Jeong HW, Lee JW, Kim WS, Choe SS, Kim KH, Park HS, Shin HJ, Lee GY, Shin D, Lee H, Lee JH, Choi EB, Lee HK, Chung H, Park SB, Park KS, Kim HS, Ro S, Kim JB.

Diabetes. 2011 Feb;60(2):496-506. doi: 10.2337/db09-1145.

15.

Underlying mechanisms of pharmacology and toxicity of a novel PPAR agonist revealed using rodent and canine hepatocytes.

Guo Y, Jolly RA, Halstead BW, Baker TK, Stutz JP, Huffman M, Calley JN, West A, Gao H, Searfoss GH, Li S, Irizarry AR, Qian HR, Stevens JL, Ryan TP.

Toxicol Sci. 2007 Apr;96(2):294-309. Epub 2007 Jan 25.

PMID:
17255113
16.

Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.

Moreno-Santos I, Pavón FJ, Romero-Cuevas M, Serrano A, Cano C, Suardíaz M, Decara J, Suarez J, de Fonseca FR, Macías-González M.

PLoS One. 2014 Mar 20;9(3):e92195. doi: 10.1371/journal.pone.0092195. eCollection 2014.

17.

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists.

Guo L, Fang H, Collins J, Fan XH, Dial S, Wong A, Mehta K, Blann E, Shi L, Tong W, Dragan YP.

BMC Bioinformatics. 2006 Sep 6;7 Suppl 2:S18.

18.

Comparative transcriptional network modeling of three PPAR-α/γ co-agonists reveals distinct metabolic gene signatures in primary human hepatocytes.

Deehan R, Maerz-Weiss P, Catlett NL, Steiner G, Wong B, Wright MB, Blander G, Elliston KO, Ladd W, Bobadilla M, Mizrahi J, Haefliger C, Edgar A.

PLoS One. 2012;7(4):e35012. doi: 10.1371/journal.pone.0035012. Epub 2012 Apr 13.

19.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.

Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga J, Ishibashi S, Yamada N.

Mol Endocrinol. 2003 Jul;17(7):1255-67. Epub 2003 May 1.

PMID:
12730332
20.

Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance.

Chang JJ, Hsu MJ, Huang HP, Chung DJ, Chang YC, Wang CJ.

J Agric Food Chem. 2013 Jun 26;61(25):6069-76. doi: 10.1021/jf401171k. Epub 2013 Jun 17.

PMID:
23731091

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