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Items: 1 to 20 of 107

1.

Cytochrome b5: novel roles in steroidogenesis.

Storbeck KH, Swart AC, Goosen P, Swart P.

Mol Cell Endocrinol. 2013 May 22;371(1-2):87-99. doi: 10.1016/j.mce.2012.11.020. Epub 2012 Dec 7. Review.

PMID:
23228600
2.

Cytochrome b5 modulates multiple reactions in steroidogenesis by diverse mechanisms.

Storbeck KH, Swart AC, Fox CL, Swart P.

J Steroid Biochem Mol Biol. 2015 Jul;151:66-73. doi: 10.1016/j.jsbmb.2014.11.024. Epub 2014 Nov 23. Review.

PMID:
25446886
3.

Role of cytochrome b5 in the modulation of the enzymatic activities of cytochrome P450 17α-hydroxylase/17,20-lyase (P450 17A1).

Bhatt MR, Khatri Y, Rodgers RJ, Martin LL.

J Steroid Biochem Mol Biol. 2017 Jun;170:2-18. doi: 10.1016/j.jsbmb.2016.02.033. Epub 2016 Mar 11. Review.

PMID:
26976652
4.

Cytochrome b5 augments 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase activity.

Goosen P, Storbeck KH, Swart AC, Conradie R, Swart P.

J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):238-47. doi: 10.1016/j.jsbmb.2011.09.001. Epub 2011 Sep 14.

PMID:
21930205
5.

Allosteric interaction between 3β-hydroxysteroid dehydrogenase/Δ⁵-Δ⁴ isomerase and cytochrome b5 influences cofactor binding.

Goosen P, Swart AC, Storbeck KH, Swart P.

FASEB J. 2013 Jan;27(1):322-32. doi: 10.1096/fj.12-213736. Epub 2012 Sep 14.

PMID:
22982379
7.

Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17.

Soucy P, Luu-The V.

J Steroid Biochem Mol Biol. 2002 Jan;80(1):71-5.

PMID:
11867265
8.

Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.

Gonzalez E, Guengerich FP.

J Biol Chem. 2017 Aug 11;292(32):13168-13185. doi: 10.1074/jbc.M117.794917. Epub 2017 Jul 6.

PMID:
28684414
9.

The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques.

Nguyen AD, Corbin CJ, Pattison JC, Bird IM, Conley AJ.

Endocrinology. 2009 Apr;150(4):1748-56. doi: 10.1210/en.2008-1303. Epub 2008 Nov 26.

10.

Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.

Estrada DF, Laurence JS, Scott EE.

J Biol Chem. 2013 Jun 7;288(23):17008-18. doi: 10.1074/jbc.M113.468926. Epub 2013 Apr 25.

11.

Cytochrome b(5) forms homomeric complexes in living cells.

Storbeck KH, Swart AC, Lombard N, Adriaanse CV, Swart P.

J Steroid Biochem Mol Biol. 2012 Nov;132(3-5):311-21. doi: 10.1016/j.jsbmb.2012.07.006. Epub 2012 Jul 31.

PMID:
22878120
12.

Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pig.

Moran FM, Ford JJ, Corbin CJ, Mapes SM, Njar VC, Brodie AM, Conley AJ.

Endocrinology. 2002 Sep;143(9):3361-9.

PMID:
12193548
13.

Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17.

Pandey AV, Miller WL.

J Biol Chem. 2005 Apr 8;280(14):13265-71. Epub 2005 Feb 1.

14.

Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.

Estrada DF, Skinner AL, Laurence JS, Scott EE.

J Biol Chem. 2014 May 16;289(20):14310-20. doi: 10.1074/jbc.M114.560144. Epub 2014 Mar 26.

15.

A Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17.

Holien JK, Parker MW, Conley AJ, Corbin CJ, Rodgers RJ, Martin LL.

Curr Protein Pept Sci. 2017;18(5):515-521. doi: 10.2174/1389203717666161220142957. Review.

PMID:
28000554
16.

CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis.

Locuson CW, Wienkers LC, Jones JP, Tracy TS.

Drug Metab Dispos. 2007 Jul;35(7):1174-81. Epub 2007 Apr 19.

17.

Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.

Peng HM, Im SC, Pearl NM, Turcu AF, Rege J, Waskell L, Auchus RJ.

Biochemistry. 2016 Aug 9;55(31):4356-65. doi: 10.1021/acs.biochem.6b00532. Epub 2016 Jul 29.

18.

Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas.

Sakai Y, Yanase T, Hara T, Takayanagi R, Haji M, Nawata H.

J Clin Endocrinol Metab. 1994 Jan;78(1):36-40.

PMID:
8288710
20.

In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome.

Sakai Y, Yanase T, Hara T, Takayanagi R, Haji M, Nawata H.

Clin Endocrinol (Oxf). 1994 Feb;40(2):205-9.

PMID:
8137519

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