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Items: 1 to 20 of 202

1.

Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review.

Mane UR, Gupta RC, Nadkarni SS, Giridhar RR, Naik PP, Yadav MR.

Expert Opin Ther Pat. 2013 Feb;23(2):165-87. doi: 10.1517/13543776.2013.743992. Epub 2012 Dec 11. Review.

PMID:
23228154
2.

Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors.

Mane UR, Li H, Huang J, Gupta RC, Nadkarni SS, Giridhar R, Naik PP, Yadav MR.

Bioorg Med Chem. 2012 Nov 1;20(21):6296-304. doi: 10.1016/j.bmc.2012.09.008. Epub 2012 Sep 13.

PMID:
23040894
3.

Falcipains, Plasmodium falciparum cysteine proteases as key drug targets against malaria.

Teixeira C, Gomes JR, Gomes P.

Curr Med Chem. 2011;18(10):1555-72. Review.

PMID:
21428877
4.

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.

Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O'Neill PM, Ward SA, Lopes F, Moreira R.

ChemMedChem. 2013 Sep;8(9):1528-36. doi: 10.1002/cmdc.201300202. Epub 2013 Jul 12.

PMID:
23853126
5.

Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library.

Shah F, Mukherjee P, Gut J, Legac J, Rosenthal PJ, Tekwani BL, Avery MA.

J Chem Inf Model. 2011 Apr 25;51(4):852-64. doi: 10.1021/ci200029y. Epub 2011 Mar 23.

PMID:
21428453
6.

The impact of whole genome sequence data on drug discovery--a malaria case study.

Joachimiak MP, Chang C, Rosenthal PJ, Cohen FE.

Mol Med. 2001 Oct;7(10):698-710.

7.

Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents.

Chakka SK, Kalamuddin M, Sundararaman S, Wei L, Mundra S, Mahesh R, Malhotra P, Mohmmed A, Kotra LP.

Bioorg Med Chem. 2015 May 1;23(9):2221-40. doi: 10.1016/j.bmc.2015.02.062. Epub 2015 Mar 18.

PMID:
25840796
8.

Falcipain-2 inhibitors.

Ettari R, Bova F, Zappalà M, Grasso S, Micale N.

Med Res Rev. 2010 Jan;30(1):136-67. doi: 10.1002/med.20163. Review.

PMID:
19526594
9.

Malarial protease inhibitors: potential new chemotherapeutic agents.

Sharma A.

Curr Opin Investig Drugs. 2007 Aug;8(8):642-52. Review.

PMID:
17668366
10.

Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent.

Huang H, Lu W, Li X, Cong X, Ma H, Liu X, Zhang Y, Che P, Ma R, Li H, Shen X, Jiang H, Huang J, Zhu J.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):958-62. doi: 10.1016/j.bmcl.2011.12.011. Epub 2011 Dec 9.

PMID:
22192590
11.

Falcipain inhibition as a promising antimalarial target.

Marco M, Coterón JM.

Curr Top Med Chem. 2012;12(5):408-44. Review.

PMID:
22242849
12.

Cysteine proteases of malaria parasites.

Rosenthal PJ.

Int J Parasitol. 2004 Dec;34(13-14):1489-99. Review.

PMID:
15582526
14.

Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.

Chen W, Huang Z, Wang W, Mao F, Guan L, Tang Y, Jiang H, Li J, Huang J, Jiang L, Zhu J.

Bioorg Med Chem. 2017 Dec 15;25(24):6467-6478. doi: 10.1016/j.bmc.2017.10.017. Epub 2017 Oct 16.

PMID:
29111368
15.

Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.

Jin H, Xu Z, Cui K, Zhang T, Lu W, Huang J.

Fitoterapia. 2014 Apr;94:55-61. doi: 10.1016/j.fitote.2014.01.017. Epub 2014 Jan 25.

PMID:
24468190
16.

Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.

Rosenthal PJ, Lee GK, Smith RE.

J Clin Invest. 1993 Mar;91(3):1052-6.

17.

Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors.

Moura PA, Dame JB, Fidock DA.

Antimicrob Agents Chemother. 2009 Dec;53(12):4968-78. doi: 10.1128/AAC.00882-09. Epub 2009 Sep 14.

18.

Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum.

Bertoldo JB, Chiaradia-Delatorre LD, Mascarello A, Leal PC, Cordeiro MN, Nunes RJ, Sarduy ES, Rosenthal PJ, Terenzi H.

J Enzyme Inhib Med Chem. 2015 Apr;30(2):299-307. doi: 10.3109/14756366.2014.920839. Epub 2014 Jun 25.

PMID:
24964346
19.

Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.

Desai PV, Patny A, Sabnis Y, Tekwani B, Gut J, Rosenthal P, Srivastava A, Avery M.

J Med Chem. 2004 Dec 16;47(26):6609-15.

PMID:
15588096
20.

Small molecule anti-malarial patents: a review (January 2010-June 2011).

Svennas KL, Macdonald SJ, Willis PA.

Expert Opin Ther Pat. 2012 Jun;22(6):607-43. doi: 10.1517/13543776.2012.691967. Review.

PMID:
22694759

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