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Items: 1 to 20 of 123

1.

Identification of PPARgamma partial agonists of natural origin (I): development of a virtual screening procedure and in vitro validation.

Guasch L, Sala E, Castell-Auví A, Cedó L, Liedl KR, Wolber G, Muehlbacher M, Mulero M, Pinent M, Ardévol A, Valls C, Pujadas G, Garcia-Vallvé S.

PLoS One. 2012;7(11):e50816. doi: 10.1371/journal.pone.0050816. Epub 2012 Nov 30.

2.

Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR) γ partial agonists.

Kaserer T, Obermoser V, Weninger A, Gust R, Schuster D.

Eur J Med Chem. 2016 Nov 29;124:49-62. doi: 10.1016/j.ejmech.2016.07.072. Epub 2016 Aug 6.

3.
4.

A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARγ partial agonists.

Vidović D, Busby SA, Griffin PR, Schürer SC.

ChemMedChem. 2011 Jan 3;6(1):94-103. doi: 10.1002/cmdc.201000428.

5.

Identification of PPARgamma partial agonists of natural origin (II): in silico prediction in natural extracts with known antidiabetic activity.

Guasch L, Sala E, Mulero M, Valls C, Salvadó MJ, Pujadas G, Garcia-Vallvé S.

PLoS One. 2013;8(2):e55889. doi: 10.1371/journal.pone.0055889. Epub 2013 Feb 6.

6.

Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma.

Atanasov AG, Blunder M, Fakhrudin N, Liu X, Noha SM, Malainer C, Kramer MP, Cocic A, Kunert O, Schinkovitz A, Heiss EH, Schuster D, Dirsch VM, Bauer R.

PLoS One. 2013 Apr 22;8(4):e61755. doi: 10.1371/journal.pone.0061755. Print 2013.

7.

Honokiol: a non-adipogenic PPARγ agonist from nature.

Atanasov AG, Wang JN, Gu SP, Bu J, Kramer MP, Baumgartner L, Fakhrudin N, Ladurner A, Malainer C, Vuorinen A, Noha SM, Schwaiger S, Rollinger JM, Schuster D, Stuppner H, Dirsch VM, Heiss EH.

Biochim Biophys Acta. 2013 Oct;1830(10):4813-9. doi: 10.1016/j.bbagen.2013.06.021. Epub 2013 Jun 27.

8.

Novel PPARγ partial agonists with weak activity and no cytotoxicity; identified by a simple PPARγ ligand screening system.

Cho MC, Lee DH, Kim EJ, Lee JY, Kang JW, Song JH, Chong Y, Kim Y, Hong JT, Yoon DY.

Mol Cell Biochem. 2011 Dec;358(1-2):75-83. doi: 10.1007/s11010-011-0923-1. Epub 2011 Jun 17.

PMID:
21681413
9.

Discovery of a novel selective PPARγ ligand with partial agonist binding properties by integrated in silico/in vitro work flow.

Kouskoumvekaki I, Petersen RK, Fratev F, Taboureau O, Nielsen TE, Oprea TI, Sonne SB, Flindt EN, Jónsdóttir SÓ, Kristiansen K.

J Chem Inf Model. 2013 Apr 22;53(4):923-37. doi: 10.1021/ci3006148. Epub 2013 Mar 19.

PMID:
23432662
10.

Structure-based virtual screening and discovery of New PPARδ/γ dual agonist and PPARδ and γ agonists.

Maltarollo VG, Togashi M, Nascimento AS, Honorio KM.

PLoS One. 2015 Mar 13;10(3):e0118790. doi: 10.1371/journal.pone.0118790. eCollection 2015.

11.

L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation.

Xie X, Zhou X, Chen W, Long L, Li W, Yang X, Li S, Wang L.

Biochim Biophys Acta. 2015 Jan;1850(1):62-72. doi: 10.1016/j.bbagen.2014.09.027. Epub 2014 Oct 12.

PMID:
25305559
12.

Structure-based pharmacophore screening for natural-product-derived PPARgamma agonists.

Tanrikulu Y, Rau O, Schwarz O, Proschak E, Siems K, Müller-Kuhrt L, Schubert-Zsilavecz M, Schneider G.

Chembiochem. 2009 Jan 5;10(1):75-8. doi: 10.1002/cbic.200800520. No abstract available.

PMID:
19067454
13.

Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

Lu IL, Huang CF, Peng YH, Lin YT, Hsieh HP, Chen CT, Lien TW, Lee HJ, Mahindroo N, Prakash E, Yueh A, Chen HY, Goparaju CM, Chen X, Liao CC, Chao YS, Hsu JT, Wu SY.

J Med Chem. 2006 May 4;49(9):2703-12.

PMID:
16640330
14.

Chebulagic acid from Terminalia chebula enhances insulin mediated glucose uptake in 3T3-L1 adipocytes via PPARγ signaling pathway.

Shyni GL, Kavitha S, Indu S, Arya AD, Anusree SS, Vineetha VP, Vandana S, Sundaresan A, Raghu KG.

Biofactors. 2014 Nov-Dec;40(6):646-57. doi: 10.1002/biof.1193. Epub 2014 Dec 20.

PMID:
25529897
15.

Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity.

Guasch L, Sala E, Valls C, Blay M, Mulero M, Arola L, Pujadas G, Garcia-Vallvé S.

J Comput Aided Mol Des. 2011 Aug;25(8):717-28. doi: 10.1007/s10822-011-9446-9. Epub 2011 Jun 21.

PMID:
21691811
16.

Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency.

Zheng W, Qiu L, Wang R, Feng X, Han Y, Zhu Y, Chen D, Liu Y, Jin L, Li Y.

Sci Rep. 2015 Jul 17;5:12222. doi: 10.1038/srep12222.

17.

Pharmacophore-driven identification of PPARγ agonists from natural sources.

Petersen RK, Christensen KB, Assimopoulou AN, Fretté X, Papageorgiou VP, Kristiansen K, Kouskoumvekaki I.

J Comput Aided Mol Des. 2011 Feb;25(2):107-16. doi: 10.1007/s10822-010-9398-5. Epub 2010 Nov 11.

PMID:
21069556
18.

LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.

Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M.

J Biol Chem. 2014 Mar 7;289(10):6908-20. doi: 10.1074/jbc.M113.506394. Epub 2014 Jan 22.

19.

Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs.

Puhl AC, Milton FA, Cvoro A, Sieglaff DH, Campos JC, Bernardes A, Filgueira CS, Lindemann JL, Deng T, Neves FA, Polikarpov I, Webb P.

Nucl Recept Signal. 2015 Oct 5;13:e004. doi: 10.1621/nrs.13004. eCollection 2015.

20.

GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.

Amato AA, Rajagopalan S, Lin JZ, Carvalho BM, Figueira AC, Lu J, Ayers SD, Mottin M, Silveira RL, Souza PC, Mourão RH, Saad MJ, Togashi M, Simeoni LA, Abdalla DS, Skaf MS, Polikparpov I, Lima MC, Galdino SL, Brennan RG, Baxter JD, Pitta IR, Webb P, Phillips KJ, Neves FA.

J Biol Chem. 2012 Aug 10;287(33):28169-79. doi: 10.1074/jbc.M111.332106. Epub 2012 May 14.

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