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High level of ATP citrate lyase expression in human and rat pancreatic islets.

MacDonald MJ, Longacre MJ, Warner TF, Thonpho A.

Horm Metab Res. 2013 May;45(5):391-3. doi: 10.1055/s-0032-1329987. Epub 2012 Dec 7.


Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

MacDonald MJ, Longacre MJ, Stoker SW, Kendrick M, Thonpho A, Brown LJ, Hasan NM, Jitrapakdee S, Fukao T, Hanson MS, Fernandez LA, Odorico J.

J Biol Chem. 2011 May 27;286(21):18383-96. doi: 10.1074/jbc.M111.241182. Epub 2011 Mar 22.


Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.

Hasan NM, Longacre MJ, Seed Ahmed M, Kendrick MA, Gu H, Ostenson CG, Fukao T, MacDonald MJ.

Arch Biochem Biophys. 2010 Jul;499(1-2):62-8. doi: 10.1016/ Epub 2010 May 9.


Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion.

Macdonald MJ, Hasan NM, Longacre MJ.

Biochim Biophys Acta. 2008 Jul-Aug;1780(7-8):966-72. doi: 10.1016/j.bbagen.2008.03.017. Epub 2008 Apr 4.


Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria.

MacDonald MJ, Stoker SW, Hasan NM.

Mol Cell Biochem. 2008 Jun;313(1-2):195-202. doi: 10.1007/s11010-008-9757-x. Epub 2008 Apr 15.


Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age.

Elshourbagy NA, Near JC, Kmetz PJ, Sathe GM, Southan C, Strickler JE, Gross M, Young JF, Wells TN, Groot PH.

J Biol Chem. 1990 Jan 25;265(3):1430-5.


Regulation of ATP-citrate lyase at transcriptional and post-transcriptional levels in rat liver.

Kim KS, Park SW, Kim YS.

Biochem Biophys Res Commun. 1992 Nov 30;189(1):264-71.


Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell.

MacDonald MJ, Smith AD 3rd, Hasan NM, Sabat G, Fahien LA.

J Biol Chem. 2007 Oct 19;282(42):30596-606. Epub 2007 Aug 27.


A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion.

Guay C, Madiraju SR, Aumais A, Joly E, Prentki M.

J Biol Chem. 2007 Dec 7;282(49):35657-65. Epub 2007 Oct 10.


Exercise training enhances rat pancreatic islets anaplerotic enzymes content despite reduced insulin secretion.

Zoppi CC, Calegari VC, Silveira LR, Carneiro EM, Boschero AC.

Eur J Appl Physiol. 2011 Sep;111(9):2369-74. doi: 10.1007/s00421-011-1842-2. Epub 2011 Feb 2.


Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes.

MacDonald MJ, Longacre MJ, Langberg EC, Tibell A, Kendrick MA, Fukao T, Ostenson CG.

Diabetologia. 2009 Jun;52(6):1087-91. doi: 10.1007/s00125-009-1319-6. Epub 2009 Mar 19.


The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

Pearce NJ, Yates JW, Berkhout TA, Jackson B, Tew D, Boyd H, Camilleri P, Sweeney P, Gribble AD, Shaw A, Groot PH.

Biochem J. 1998 Aug 15;334 ( Pt 1):113-9.


Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.

Joseph JW, Odegaard ML, Ronnebaum SM, Burgess SC, Muehlbauer J, Sherry AD, Newgard CB.

J Biol Chem. 2007 Oct 26;282(43):31592-600. Epub 2007 Sep 6.


Effects of nutrients and hormones on gene expression of ATP citrate-lyase in rat liver.

Fukuda H, Katsurada A, Iritani N.

Eur J Biochem. 1992 Oct 1;209(1):217-22.


Effects of phosphorylation on the kinetic properties of rat liver ATP-citrate lyase.

Houston B, Nimmo HG.

Biochim Biophys Acta. 1985 Feb 21;844(2):233-9.


Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion.

El Azzouny M, Longacre MJ, Ansari IU, Kennedy RT, Burant CF, MacDonald MJ.

Mol Metab. 2016 Aug 8;5(10):980-7. doi: 10.1016/j.molmet.2016.07.011. eCollection 2016 Oct.


Cloning and expression of a human ATP-citrate lyase cDNA.

Elshourbagy NA, Near JC, Kmetz PJ, Wells TN, Groot PH, Saxty BA, Hughes SA, Franklin M, Gloger IS.

Eur J Biochem. 1992 Mar 1;204(2):491-9.


Purification and some properties of ATP-citrate lyase from rat brain.

Szutowicz A, Srere PA.

Arch Biochem Biophys. 1983 Feb 15;221(1):168-74.


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