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Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells.

Oubrahim H, Wong A, Wilson BA, Chock PB.

J Biol Chem. 2013 Jan 25;288(4):2805-15. doi: 10.1074/jbc.M112.427351. Epub 2012 Dec 7.


Pasteurella multocida toxin (PMT) upregulates CTGF which leads to mTORC1 activation in Swiss 3T3 cells.

Oubrahim H, Wong A, Wilson BA, Chock PB.

Cell Signal. 2013 May;25(5):1136-48. doi: 10.1016/j.cellsig.2013.01.026. Epub 2013 Feb 13.


Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation.

Kloos B, Chakraborty S, Lindner SG, Noack K, Harre U, Schett G, Krämer OH, Kubatzky KF.

Cell Commun Signal. 2015 Sep 14;13:40. doi: 10.1186/s12964-015-0117-7.


Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13.

Orth JH, Lang S, Taniguchi M, Aktories K.

J Biol Chem. 2005 Nov 4;280(44):36701-7. Epub 2005 Sep 1.


Modification of heterotrimeric G-proteins in Swiss 3T3 cells stimulated with Pasteurella multocida toxin.

Babb RC, Homer KA, Robbins J, Lax AJ.

PLoS One. 2012;7(11):e47188. doi: 10.1371/journal.pone.0047188. Epub 2012 Nov 5.


Enzymatic actions of Pasteurella multocida toxin detected by monoclonal antibodies recognizing the deamidated α subunit of the heterotrimeric GTPase Gq.

Kamitani S, Ao S, Toshima H, Tachibana T, Hashimoto M, Kitadokoro K, Fukui-Miyazaki A, Abe H, Horiguchi Y.

FEBS J. 2011 Aug;278(15):2702-12. doi: 10.1111/j.1742-4658.2011.08197.x. Epub 2011 Jun 13.


Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin.

Orth JH, Fester I, Preuss I, Agnoletto L, Wilson BA, Aktories K.

J Biol Chem. 2008 Aug 22;283(34):23288-94. doi: 10.1074/jbc.M803435200. Epub 2008 Jun 26.


Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis.

Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K, Orth JH.

PLoS Pathog. 2013;9(5):e1003385. doi: 10.1371/journal.ppat.1003385. Epub 2013 May 16.


Action of Pasteurella multocida toxin depends on the helical domain of Galphaq.

Orth JH, Lang S, Aktories K.

J Biol Chem. 2004 Aug 13;279(33):34150-5. Epub 2004 Jun 10.


Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin.

Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth JH.

MBio. 2014 Nov 11;5(6):e02190. doi: 10.1128/mBio.02190-14.


Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. involvement of Gq but not G11.

Zywietz A, Gohla A, Schmelz M, Schultz G, Offermanns S.

J Biol Chem. 2001 Feb 9;276(6):3840-5. Epub 2000 Nov 2.


Action of Pasteurella multocida toxin on Galpha(q) is persistent and independent of interaction with G-protein-coupled receptors.

Orth JH, Lang S, Preuss I, Milligan G, Aktories K.

Cell Signal. 2007 Oct;19(10):2174-82. Epub 2007 Jun 29.


The pasteurella multocida toxin interacts with signalling pathways to perturb cell growth and differentiation.

Lax AJ, Pullinger GD, Baldwin MR, Harmey D, Grigoriadis AE, Lakey JH.

Int J Med Microbiol. 2004 Apr;293(7-8):505-12. Review.


Substrate specificity of Pasteurella multocida toxin for α subunits of heterotrimeric G proteins.

Orth JH, Fester I, Siegert P, Weise M, Lanner U, Kamitani S, Tachibana T, Wilson BA, Schlosser A, Horiguchi Y, Aktories K.

FASEB J. 2013 Feb;27(2):832-42. doi: 10.1096/fj.12-213900. Epub 2012 Nov 12.


Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins.

Preuss I, Kurig B, Nürnberg B, Orth JH, Aktories K.

Cell Signal. 2009 Apr;21(4):551-8. doi: 10.1016/j.cellsig.2008.12.007. Epub 2008 Dec 24.


Differential modulation and subsequent blockade of mitogenic signaling and cell cycle progression by Pasteurella multocida toxin.

Wilson BA, Aminova LR, Ponferrada VG, Ho M.

Infect Immun. 2000 Aug;68(8):4531-8. Erratum in: Infect Immun 2001 Dec;69(12):7965.


Pasteurella multocida toxin facilitates inositol phosphate formation by bombesin through tyrosine phosphorylation of G alpha q.

Baldwin MR, Pullinger GD, Lax AJ.

J Biol Chem. 2003 Aug 29;278(35):32719-25. Epub 2003 Jun 10.


Selective Membrane Redistribution and Depletion of Gαq-Protein by Pasteurella multocida Toxin.

Clemons NC, Luo S, Ho M, Wilson BA.

Toxins (Basel). 2016 Aug 1;8(8). pii: E233. doi: 10.3390/toxins8080233.


Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation.

Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA.

PLoS One. 2017 Sep 19;12(9):e0184818. doi: 10.1371/journal.pone.0184818. eCollection 2017.

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