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Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer.

Esser AK, Miller MR, Huang Q, Meier MM, Beltran-Valero de Bernabé D, Stipp CS, Campbell KP, Lynch CF, Smith BJ, Cohen MB, Henry MD.

J Biol Chem. 2013 Jan 25;288(4):2132-42. doi: 10.1074/jbc.M112.432807. Epub 2012 Dec 6.


The glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer.

Huang Q, Miller MR, Schappet J, Henry MD.

Cancer Biol Ther. 2015;16(1):125-36. doi: 10.4161/15384047.2014.987078.


Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma.

Miller MR, Ma D, Schappet J, Breheny P, Mott SL, Bannick N, Askeland E, Brown J, Henry MD.

Mol Cancer. 2015 Jul 30;14:141. doi: 10.1186/s12943-015-0416-z.


Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.

Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE.

Glycobiology. 2005 Oct;15(10):912-23. Epub 2005 Jun 15.


Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer.

Shimojo H, Kobayashi M, Kamigaito T, Shimojo Y, Fukuda M, Nakayama J.

Prostate. 2011 Aug 1;71(11):1151-7. doi: 10.1002/pros.21330. Epub 2011 Jan 12.


Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues.

Inamori K, Willer T, Hara Y, Venzke D, Anderson ME, Clarke NF, Guicheney P, Bönnemann CG, Moore SA, Campbell KP.

J Biol Chem. 2014 Oct 10;289(41):28138-48. doi: 10.1074/jbc.M114.597831. Epub 2014 Aug 19.


Fer kinase regulates cell migration through α-dystroglycan glycosylation.

Yoneyama T, Angata K, Bao X, Courtneidge S, Chanda SK, Fukuda M.

Mol Biol Cell. 2012 Mar;23(5):771-80. doi: 10.1091/mbc.E11-06-0517. Epub 2012 Jan 11.


Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase.

Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, Fukuda MN, Fukuda M.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12109-14. doi: 10.1073/pnas.0904515106. Epub 2009 Jul 8.


Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE.

de Bernabé DB, Inamori K, Yoshida-Moriguchi T, Weydert CJ, Harper HA, Willer T, Henry MD, Campbell KP.

J Biol Chem. 2009 Apr 24;284(17):11279-84. doi: 10.1074/jbc.C900007200. Epub 2009 Feb 24.


Correlation of deregulated like-acetylglucosaminyl transferase and aberrant α-dystroglycan expression with human tongue cancer metastasis.

Zhang HZ, Xia XY, Zhu F, Shen H, Song K, Shang ZJ.

J Oral Maxillofac Surg. 2014 Jun;72(6):1106-18. doi: 10.1016/j.joms.2013.12.031. Epub 2014 Jan 15.


A role of fukutin, a gene responsible for Fukuyama type congenital muscular dystrophy, in cancer cells: a possible role to suppress cell proliferation.

Yamamoto T, Kato Y, Shibata N, Sawada T, Osawa M, Kobayashi M.

Int J Exp Pathol. 2008 Oct;89(5):332-41. doi: 10.1111/j.1365-2613.2008.00599.x.


Differential glycosylation of α-dystroglycan and proteins other than α-dystroglycan by like-glycosyltransferase.

Zhang P, Hu H.

Glycobiology. 2012 Feb;22(2):235-47. doi: 10.1093/glycob/cwr131. Epub 2011 Sep 19.


Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2.

Inamori K, Hara Y, Willer T, Anderson ME, Zhu Z, Yoshida-Moriguchi T, Campbell KP.

Glycobiology. 2013 Mar;23(3):295-302. doi: 10.1093/glycob/cws152. Epub 2012 Nov 2.


Dystroglycan expression is reduced during prostate tumorigenesis and is regulated by androgens in prostate cancer cells.

Sgambato A, De Paola B, Migaldi M, Di Salvatore M, Rettino A, Rossi G, Faraglia B, Boninsegna A, Maiorana A, Cittadini A.

J Cell Physiol. 2007 Nov;213(2):528-39.


Missense mutations in β-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker-Warburg syndrome.

Buysse K, Riemersma M, Powell G, van Reeuwijk J, Chitayat D, Roscioli T, Kamsteeg EJ, van den Elzen C, van Beusekom E, Blaser S, Babul-Hirji R, Halliday W, Wright GJ, Stemple DL, Lin YY, Lefeber DJ, van Bokhoven H.

Hum Mol Genet. 2013 May 1;22(9):1746-54. doi: 10.1093/hmg/ddt021. Epub 2013 Jan 28.


LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE.

Fujimura K, Sawaki H, Sakai T, Hiruma T, Nakanishi N, Sato T, Ohkura T, Narimatsu H.

Biochem Biophys Res Commun. 2005 Apr 15;329(3):1162-71.


LARGE expression augments the glycosylation of glycoproteins in addition to α-dystroglycan conferring laminin binding.

Zhang Z, Zhang P, Hu H.

PLoS One. 2011 Apr 20;6(4):e19080. doi: 10.1371/journal.pone.0019080.


LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans.

Inamori KI, Beedle AM, de Bernabé DB, Wright ME, Campbell KP.

Glycobiology. 2016 Jul 22. [Epub ahead of print]


Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on α-dystroglycan.

Nakagawa N, Manya H, Toda T, Endo T, Oka S.

J Biol Chem. 2012 Aug 31;287(36):30823-32. doi: 10.1074/jbc.M112.363036. Epub 2012 Jul 16.

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