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The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.

Lösing M, Goldbeck I, Manno B, Oellerich T, Schnyder T, Bohnenberger H, Stork B, Urlaub H, Batista FD, Wienands J, Engelke M.

J Biol Chem. 2013 Jan 25;288(4):2303-13. doi: 10.1074/jbc.M112.406546. Epub 2012 Dec 5.


Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells.

Stork B, Neumann K, Goldbeck I, Alers S, Kähne T, Naumann M, Engelke M, Wienands J.

EMBO J. 2007 Feb 21;26(4):1140-9. Epub 2007 Feb 8.


Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells.

Neumann K, Oellerich T, Heine I, Urlaub H, Engelke M.

Cell Signal. 2011 May;23(5):893-900. doi: 10.1016/j.cellsig.2011.01.015. Epub 2011 Jan 22.


The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.

Manno B, Oellerich T, Schnyder T, Corso J, Lösing M, Neumann K, Urlaub H, Batista FD, Engelke M, Wienands J.

Eur J Immunol. 2016 Nov;46(11):2520-2530. doi: 10.1002/eji.201646431. Epub 2016 Sep 14.


B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.

Schnyder T, Castello A, Feest C, Harwood NE, Oellerich T, Urlaub H, Engelke M, Wienands J, Bruckbauer A, Batista FD.

Immunity. 2011 Jun 24;34(6):905-18. doi: 10.1016/j.immuni.2011.06.001.


CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.

Otipoby KL, Draves KE, Clark EA.

J Biol Chem. 2001 Nov 23;276(47):44315-22. Epub 2001 Sep 10.


Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.

Senis YA, Antrobus R, Severin S, Parguiña AF, Rosa I, Zitzmann N, Watson SP, García A.

J Thromb Haemost. 2009 Oct;7(10):1718-26. doi: 10.1111/j.1538-7836.2009.03565.x. Epub 2009 Aug 11.


The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent.

Xu Y, Beavitt SJ, Harder KW, Hibbs ML, Tarlinton DM.

J Immunol. 2002 Dec 15;169(12):6910-8.


T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2.

Dong S, Corre B, Foulon E, Dufour E, Veillette A, Acuto O, Michel F.

J Exp Med. 2006 Oct 30;203(11):2509-18. Epub 2006 Oct 16.


BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.

Yokoyama K, Su Ih IH, Tezuka T, Yasuda T, Mikoshiba K, Tarakhovsky A, Yamamoto T.

EMBO J. 2002 Jan 15;21(1-2):83-92.


The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.

Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T.

Blood. 2007 Oct 1;110(7):2511-9. Epub 2007 May 18. Erratum in: Blood. 2008 Mar 15;111(6):3299.


B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1.

Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D.

J Exp Med. 2001 Aug 20;194(4):529-39.


Functional analysis of Csk in signal transduction through the B-cell antigen receptor.

Hata A, Sabe H, Kurosaki T, Takata M, Hanafusa H.

Mol Cell Biol. 1994 Nov;14(11):7306-13.


Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.

Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD.

J Biol Chem. 2002 Apr 19;277(16):13732-8. Epub 2002 Feb 1.


What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling.

Reth M, Gold MR.

Eur J Immunol. 2016 Nov;46(11):2507-2511. doi: 10.1002/eji.201646705.

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