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Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy.

Niso-Santano M, Shen S, Adjemian S, Malik SA, Mariño G, Lachkar S, Senovilla L, Kepp O, Galluzzi L, Maiuri MC, Kroemer G.

Autophagy. 2013 Mar;9(3):415-7. doi: 10.4161/auto.22910. Epub 2012 Dec 7.


Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.

Shen S, Niso-Santano M, Adjemian S, Takehara T, Malik SA, Minoux H, Souquere S, Mariño G, Lachkar S, Senovilla L, Galluzzi L, Kepp O, Pierron G, Maiuri MC, Hikita H, Kroemer R, Kroemer G.

Mol Cell. 2012 Dec 14;48(5):667-80. doi: 10.1016/j.molcel.2012.09.013. Epub 2012 Oct 17.


The role of STAT3 in autophagy.

You L, Wang Z, Li H, Shou J, Jing Z, Xie J, Sui X, Pan H, Han W.

Autophagy. 2015;11(5):729-39. doi: 10.1080/15548627.2015.1017192. Review.


Phosphorylated heat shock protein 27 promotes lipid clearance in hepatic cells through interacting with STAT3 and activating autophagy.

Shen L, Qi Z, Zhu Y, Song X, Xuan C, Ben P, Lan L, Luo L, Yin Z.

Cell Signal. 2016 Aug;28(8):1086-98. doi: 10.1016/j.cellsig.2016.05.008. Epub 2016 May 13.


eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

Papadakis AI, Paraskeva E, Peidis P, Muaddi H, Li S, Raptis L, Pantopoulos K, Simos G, Koromilas AE.

Cancer Res. 2010 Oct 15;70(20):7820-9. doi: 10.1158/0008-5472.CAN-10-0215. Epub 2010 Oct 5.


RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways.

Siddiqui MA, Malathi K.

J Biol Chem. 2012 Dec 21;287(52):43651-64. doi: 10.1074/jbc.M112.399964. Epub 2012 Oct 29.


Decoding cell death signals in liver inflammation.

Brenner C, Galluzzi L, Kepp O, Kroemer G.

J Hepatol. 2013 Sep;59(3):583-94. doi: 10.1016/j.jhep.2013.03.033. Epub 2013 Apr 6. Review.


The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase.

Wang S, Raven JF, Baltzis D, Kazemi S, Brunet DV, Hatzoglou M, Tremblay ML, Koromilas AE.

J Biol Chem. 2006 Apr 7;281(14):9439-49. Epub 2006 Jan 23.


Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.

Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR.

EMBO J. 2001 May 15;20(10):2487-96.


SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.

Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV.

Clin Cancer Res. 2006 Nov 15;12(22):6844-52.


Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells.

Pratt J, Annabi B.

Cell Signal. 2014 May;26(5):917-24. doi: 10.1016/j.cellsig.2014.01.012. Epub 2014 Jan 22.


Regulation of autophagy by stress-responsive transcription factors.

Pietrocola F, Izzo V, Niso-Santano M, Vacchelli E, Galluzzi L, Maiuri MC, Kroemer G.

Semin Cancer Biol. 2013 Oct;23(5):310-22. doi: 10.1016/j.semcancer.2013.05.008. Epub 2013 May 30. Review.


Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins.

Mouna L, Hernandez E, Bonte D, Brost R, Amazit L, Delgui LR, Brune W, Geballe AP, Beau I, Esclatine A.

Autophagy. 2016;12(2):327-42. doi: 10.1080/15548627.2015.1125071.


Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.

Lo RK, Cheung H, Wong YH.

J Biol Chem. 2003 Dec 26;278(52):52154-65. Epub 2003 Oct 9.

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