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Items: 1 to 20 of 100

1.

Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase.

Okuwa H, Kanno T, Fujita Y, Gotoh A, Tabata C, Fukuoka K, Nakano T, Nishizaki T.

Cell Physiol Biochem. 2012;30(4):995-1004. doi: 10.1159/000341476. Epub 2012 Sep 20.

2.

Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.

Lim JH, Park JW, Choi KS, Park YB, Kwon TK.

Carcinogenesis. 2009 May;30(5):729-36. doi: 10.1093/carcin/bgn265. Epub 2008 Nov 26.

PMID:
19037087
3.

Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism.

Lim JH, Woo SM, Min KJ, Park EJ, Jang JH, Seo BR, Iqbal T, Lee TJ, Kim SH, Choi YH, Kwon TK.

Chem Biol Interact. 2012 Apr 15;197(1):1-7. doi: 10.1016/j.cbi.2012.02.003. Epub 2012 Mar 5.

PMID:
22410117
4.

[The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism].

Chen ZF, Fang JY, Weng YR, Sun DF, Wang X, Lu R.

Zhonghua Zhong Liu Za Zhi. 2006 Aug;28(8):564-7. Chinese.

PMID:
17236547
5.

Activation of PKC-δ in HTLV-1-infected T cells.

Mori N, Ishikawa C, Senba M.

Int J Oncol. 2015 Apr;46(4):1609-18. doi: 10.3892/ijo.2015.2848. Epub 2015 Jan 26.

PMID:
25625567
6.

Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.

Cerda SR, Mustafi R, Little H, Cohen G, Khare S, Moore C, Majumder P, Bissonnette M.

Oncogene. 2006 May 25;25(22):3123-38.

PMID:
16434969
7.

Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation.

Kim YR, Byun HS, Jeon J, Choi BL, Park KA, Won M, Zhang T, Shin S, Lee H, Oh J, Hur GM.

Cell Biochem Biophys. 2011 Sep;61(1):199-207. doi: 10.1007/s12013-011-9189-1.

PMID:
21468691
8.

Sphingosine induces apoptosis in MKN-28 human gastric cancer cells in an SDK-dependent manner.

Kanno T, Nishimoto T, Fujita Y, Gotoh A, Nakano T, Nishizaki T.

Cell Physiol Biochem. 2012;30(4):987-94. doi: 10.1159/000341475. Epub 2012 Sep 20.

9.

Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells.

Lim JH, Park JW, Kim SH, Choi YH, Choi KS, Kwon TK.

Apoptosis. 2008 Nov;13(11):1378-85. doi: 10.1007/s10495-008-0264-z.

PMID:
18807195
10.

Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway.

Basu A, Adkins B, Basu C.

Cancer Res. 2008 Apr 15;68(8):2795-802. doi: 10.1158/0008-5472.CAN-07-6244.

11.

Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor.

Honda M, Kanno T, Fujita Y, Gotoh A, Nakano T, Nishizaki T.

Cell Physiol Biochem. 2012;29(5-6):667-74. doi: 10.1159/000176386. Epub 2012 May 11.

12.

Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells.

Eguchi R, Kubo S, Takeda H, Ohta T, Tabata C, Ogawa H, Nakano T, Fujimori Y.

Carcinogenesis. 2012 May;33(5):969-75. doi: 10.1093/carcin/bgs109. Epub 2012 Feb 21.

PMID:
22354875
13.

Translocation of protein kinase C δ contributes to the moderately high glucose-, but not hypoxia-induced proliferation in primary cultured human retinal endothelial cells.

Liu ZC, Yu EH, Liu W, Liu XC, Tang SB, Zhu BH.

Mol Med Rep. 2014 May;9(5):1780-6. doi: 10.3892/mmr.2014.2049. Epub 2014 Mar 13.

PMID:
24626810
14.

A molecular targeting against nuclear factor-κB, as a chemotherapeutic approach for human malignant mesothelioma.

Nishikawa S, Tanaka A, Matsuda A, Oida K, Jang H, Jung K, Amagai Y, Ahn G, Okamoto N, Ishizaka S, Matsuda H.

Cancer Med. 2014 Apr;3(2):416-25. doi: 10.1002/cam4.202. Epub 2014 Feb 10.

15.

Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis.

Song KS, Kim JS, Yun EJ, Kim YR, Seo KS, Park JH, Jung YJ, Park JI, Kweon GR, Yoon WH, Lim K, Hwang BD.

Autophagy. 2008 Jul;4(5):650-8. Epub 2008 Apr 7.

PMID:
18424913
16.

Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis.

Ni H, Ergin M, Tibudan SS, Denning MF, Izban KF, Alkan S.

Br J Haematol. 2003 Jun;121(6):849-56.

PMID:
12786795
17.

Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.

Kim YH, Kim YS, Park CH, Chung IY, Yoo JM, Kim JG, Lee BJ, Kang SS, Cho GJ, Choi WS.

Diabetes. 2008 Aug;57(8):2181-90. doi: 10.2337/db07-1431. Epub 2008 Apr 28.

18.
19.

Naftopidil induces apoptosis in malignant mesothelioma cell lines independently of α1-adrenoceptor blocking.

Masachika E, Kanno T, Nakano T, Gotoh A, Nishizaki T.

Anticancer Res. 2013 Mar;33(3):887-94.

PMID:
23482758
20.

The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression.

Kitamura K, Mizuno K, Etoh A, Akita Y, Miyamoto A, Nakayama K, Ohno S.

Genes Cells. 2003 Apr;8(4):311-24.

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