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Items: 1 to 20 of 72

1.

The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily.

Parsiegla G, Noguere C, Santell L, Lazarus RA, Bourne Y.

Biochemistry. 2012 Dec 21;51(51):10250-8. doi: 10.1021/bi300873f. Epub 2012 Dec 13.

PMID:
23215638
2.

Site-directed mutagenesis of the catalytic residues of bovine pancreatic deoxyribonuclease I.

Jones SJ, Worrall AF, Connolly BA.

J Mol Biol. 1996 Dec 20;264(5):1154-63.

PMID:
9000637
3.

DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites.

Horton NC, Perona JJ.

Biochemistry. 2004 Jun 8;43(22):6841-57.

PMID:
15170321
4.

In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis.

Shah PL, Scott SF, Knight RA, Marriott C, Ranasinha C, Hodson ME.

Thorax. 1996 Feb;51(2):119-25.

6.

Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.

Shak S, Capon DJ, Hellmiss R, Marsters SA, Baker CL.

Proc Natl Acad Sci U S A. 1990 Dec;87(23):9188-92.

7.
8.

How cations can assist DNase I in DNA binding and hydrolysis.

Guéroult M, Picot D, Abi-Ghanem J, Hartmann B, Baaden M.

PLoS Comput Biol. 2010 Nov 18;6(11):e1001000. doi: 10.1371/journal.pcbi.1001000.

9.

[rhDNase: scientific background, cloning and production].

Shak S.

Arch Pediatr. 1995 Jul;2(7):666-9. Review. French.

PMID:
7663657
10.

Engineering the enolase magnesium II binding site: implications for its evolution.

Schreier B, Höcker B.

Biochemistry. 2010 Sep 7;49(35):7582-9. doi: 10.1021/bi100954f.

PMID:
20690637
11.

Improved potency of hyperactive and actin-resistant human DNase I variants for treatment of cystic fibrosis and systemic lupus erythematosus.

Pan CQ, Dodge TH, Baker DL, Prince WS, Sinicropi DV, Lazarus RA.

J Biol Chem. 1998 Jul 17;273(29):18374-81.

12.
13.

Engineering actin-resistant human DNase I for treatment of cystic fibrosis.

Ulmer JS, Herzka A, Toy KJ, Baker DL, Dodge AH, Sinicropi D, Shak S, Lazarus RA.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8225-9.

14.

Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.

Chan S, Segelke B, Lekin T, Krupka H, Cho US, Kim MY, So M, Kim CY, Naranjo CM, Rogers YC, Park MS, Waldo GS, Pashkov I, Cascio D, Perry JL, Sawaya MR.

J Mol Biol. 2004 Aug 6;341(2):503-17.

PMID:
15276840
15.
16.
17.

Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group.

Fuchs HJ, Borowitz DS, Christiansen DH, Morris EM, Nash ML, Ramsey BW, Rosenstein BJ, Smith AL, Wohl ME.

N Engl J Med. 1994 Sep 8;331(10):637-42.

18.

Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.

Zha M, Guo Q, Zhang Y, Yu B, Ou Y, Zhong C, Ding J.

J Mol Biol. 2008 Jun 6;379(3):568-78. doi: 10.1016/j.jmb.2008.04.006. Epub 2008 Apr 8.

PMID:
18462755
19.

Structure and function of bovine pancreatic deoxyribonuclease I.

Chen WJ, Liao TH.

Protein Pept Lett. 2006;13(5):447-53. Review.

PMID:
16800797
20.

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