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Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia.

Al-Wadei MH, Al-Wadei HA, Schuller HM.

Cancer Prev Res (Phila). 2013 Feb;6(2):139-48. doi: 10.1158/1940-6207.CAPR-12-0388. Epub 2012 Dec 4.


Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling.

Al-Wadei MH, Banerjee J, Al-Wadei HA, Schuller HM.

Eur J Cancer. 2016 Jan;52:188-96. doi: 10.1016/j.ejca.2015.10.003. Epub 2015 Dec 12.


Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters.

Al-Wadei MH, Al-Wadei HA, Schuller HM.

Carcinogenesis. 2012 Sep;33(9):1745-53. doi: 10.1093/carcin/bgs229. Epub 2012 Jul 12. Erratum in: Carcinogenesis. 2014 Nov;35(11):2630.


Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7.

Al-Wadei MH, Al-Wadei HA, Schuller HM.

Mol Cancer Res. 2012 Feb;10(2):239-49. doi: 10.1158/1541-7786.MCR-11-0332. Epub 2011 Dec 21.


GABA B receptor is a novel drug target for pancreatic cancer.

Schuller HM, Al-Wadei HA, Majidi M.

Cancer. 2008 Feb 15;112(4):767-78.


Prevention of pancreatic cancer by the beta-blocker propranolol.

Al-Wadei HA, Al-Wadei MH, Schuller HM.

Anticancer Drugs. 2009 Jul;20(6):477-82. doi: 10.1097/CAD.0b013e32832bd1e3.


Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid.

Al-Wadei HA, Plummer HK 3rd, Schuller HM.

Carcinogenesis. 2009 Mar;30(3):506-11. doi: 10.1093/carcin/bgp010. Epub 2009 Jan 8.


Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro and in xenograft models of stress-free and stress-exposed mice.

Al-Wadei HA, Al-Wadei MH, Ullah MF, Schuller HM.

PLoS One. 2012;7(8):e43376. doi: 10.1371/journal.pone.0043376. Epub 2012 Aug 16.


Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit.

Takehara A, Hosokawa M, Eguchi H, Ohigashi H, Ishikawa O, Nakamura Y, Nakagawa H.

Cancer Res. 2007 Oct 15;67(20):9704-12.


Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention.

Al-Wadei HA, Al-Wadei MH, Schuller HM.

PLoS One. 2012;7(1):e29915. doi: 10.1371/journal.pone.0029915. Epub 2012 Jan 12.


Expression and regulation of nicotine receptor and osteopontin isoforms in human pancreatic ductal adenocarcinoma.

Sullivan J, Blair L, Alnajar A, Aziz T, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA.

Histol Histopathol. 2011 Jul;26(7):893-904. doi: 10.14670/HH-26.893.


GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.

Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernández-Zapico ME, Hanahan D.

Genes Dev. 2009 Jan 1;23(1):24-36. doi: 10.1101/gad.1753809.


Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice.

Jandaghi P, Najafabadi HS, Bauer AS, Papadakis AI, Fassan M, Hall A, Monast A, von Knebel Doeberitz M, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Sipos B, Auld D, Lathrop M, Park M, Büchler MW, Strobel O, Hackert T, Giese NA, Zogopoulos G, Sangwan V, Huang S, Riazalhosseini Y, Hoheisel JD.

Gastroenterology. 2016 Dec;151(6):1218-1231. doi: 10.1053/j.gastro.2016.08.040. Epub 2016 Aug 28.


Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention.

Schuller HM, Al-Wadei HA, Ullah MF, Plummer HK 3rd.

Carcinogenesis. 2012 Jan;33(1):191-6. doi: 10.1093/carcin/bgr251. Epub 2011 Nov 9.


Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer.

Al-Wadei HA, Plummer HK 3rd, Ullah MF, Unger B, Brody JR, Schuller HM.

Cancer Prev Res (Phila). 2012 Feb;5(2):189-96. doi: 10.1158/1940-6207.CAPR-11-0177. Epub 2011 Sep 28.


Kif20a inhibition reduces migration and invasion of pancreatic cancer cells.

Stangel D, Erkan M, Buchholz M, Gress T, Michalski C, Raulefs S, Friess H, Kleeff J.

J Surg Res. 2015 Jul;197(1):91-100. doi: 10.1016/j.jss.2015.03.070. Epub 2015 Mar 30.


A gene expression signature of epithelial tubulogenesis and a role for ASPM in pancreatic tumor progression.

Wang WY, Hsu CC, Wang TY, Li CR, Hou YC, Chu JM, Lee CT, Liu MS, Su JJ, Jian KY, Huang SS, Jiang SS, Shan YS, Lin PW, Shen YY, Lee MT, Chan TS, Chang CC, Chen CH, Chang IS, Lee YL, Chen LT, Tsai KK.

Gastroenterology. 2013 Nov;145(5):1110-20. doi: 10.1053/j.gastro.2013.07.040. Epub 2013 Jul 27.


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