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Items: 1 to 20 of 98

1.

Structure-function studies with G protein-coupled receptors as a paradigm for improving drug discovery and development of therapeutics.

McNeely PM, Naranjo AN, Robinson AS.

Biotechnol J. 2012 Dec;7(12):1451-61. doi: 10.1002/biot.201200076. Review.

2.

Structure and function of G protein-coupled receptor oligomers: implications for drug discovery.

Schonenbach NS, Hussain S, O'Malley MA.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 May-Jun;7(3):408-27. doi: 10.1002/wnan.1319. Epub 2014 Dec 17. Review.

PMID:
25521522
3.

G Protein-Coupled Receptor Heteromers.

Gomes I, Ayoub MA, Fujita W, Jaeger WC, Pfleger KD, Devi LA.

Annu Rev Pharmacol Toxicol. 2016;56:403-25. doi: 10.1146/annurev-pharmtox-011613-135952. Epub 2015 Oct 22. Review.

4.

Emerging Approaches to GPCR Ligand Screening for Drug Discovery.

Kumari P, Ghosh E, Shukla AK.

Trends Mol Med. 2015 Nov;21(11):687-701. doi: 10.1016/j.molmed.2015.09.002. Epub 2015 Oct 16. Review.

PMID:
26481827
5.

Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.

Kimple AJ, Bosch DE, Giguère PM, Siderovski DP.

Pharmacol Rev. 2011 Sep;63(3):728-49. doi: 10.1124/pr.110.003038. Epub 2011 Jul 7. Review.

6.

G Protein-coupled Receptor Biased Agonism.

Hodavance SY, Gareri C, Torok RD, Rockman HA.

J Cardiovasc Pharmacol. 2016 Mar;67(3):193-202. doi: 10.1097/FJC.0000000000000356. Review.

7.

The significance of G protein-coupled receptor crystallography for drug discovery.

Salon JA, Lodowski DT, Palczewski K.

Pharmacol Rev. 2011 Dec;63(4):901-37. doi: 10.1124/pr.110.003350. Review.

8.

From purified GPCRs to drug discovery: the promise of protein-based methodologies.

Alkhalfioui F, Magnin T, Wagner R.

Curr Opin Pharmacol. 2009 Oct;9(5):629-35. doi: 10.1016/j.coph.2009.04.002. Epub 2009 May 13. Review.

PMID:
19443270
9.

Receptor heteromerization and drug discovery.

Rozenfeld R, Devi LA.

Trends Pharmacol Sci. 2010 Mar;31(3):124-30. doi: 10.1016/j.tips.2009.11.008. Epub 2010 Jan 7.

10.

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.

Tang XL, Wang Y, Li DL, Luo J, Liu MY.

Acta Pharmacol Sin. 2012 Mar;33(3):363-71. doi: 10.1038/aps.2011.210. Epub 2012 Feb 27. Review.

11.

High throughput screening (HTS) in identification new ligands and drugable targets of G protein-coupled receptors (GPCRs).

Wang D, Li Y, Zhang Y, Liu Y, Shi G.

Comb Chem High Throughput Screen. 2012 Mar;15(3):232-41. Review.

PMID:
22221056
12.

G-protein-coupled receptor-focused drug discovery using a target class platform approach.

Heilker R, Wolff M, Tautermann CS, Bieler M.

Drug Discov Today. 2009 Mar;14(5-6):231-40. doi: 10.1016/j.drudis.2008.11.011. Epub 2009 Jan 22. Review.

PMID:
19121411
13.

Strategies to discover unexpected targets for drugs active at G protein-coupled receptors.

Allen JA, Roth BL.

Annu Rev Pharmacol Toxicol. 2011;51:117-44. doi: 10.1146/annurev-pharmtox-010510-100553. Review.

PMID:
20868273
14.

Receptor activity modifying proteins and their potential as drug targets.

Wootten DL, Simms J, Hay DL, Christopoulos A, Sexton PM.

Prog Mol Biol Transl Sci. 2010;91:53-79. doi: 10.1016/S1877-1173(10)91003-X. Review.

PMID:
20691959
15.

G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy.

Ding X, Zhao X, Watts A.

Biochem J. 2013 Mar 15;450(3):443-57. doi: 10.1042/BJ20121644. Review. Erratum in: Biochem J. 2013 Apr 15;451(2):343.

PMID:
23445222
16.

Label-free cell-based assays for GPCR screening.

Fang Y, Frutos AG, Verklereen R.

Comb Chem High Throughput Screen. 2008 Jun;11(5):357-69. Review.

PMID:
18537557
17.

Structural mechanism of G protein activation by G protein-coupled receptor.

Duc NM, Kim HR, Chung KY.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):214-22. doi: 10.1016/j.ejphar.2015.05.016. Epub 2015 May 14. Review.

PMID:
25981300
18.

GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeutics.

Mujić-Delić A, de Wit RH, Verkaar F, Smit MJ.

Trends Pharmacol Sci. 2014 May;35(5):247-55. doi: 10.1016/j.tips.2014.03.003. Epub 2014 Mar 30. Review.

PMID:
24690241
19.

G protein-coupled receptors: abnormalities in signal transmission, disease states and pharmacotherapy.

Zalewska M, Siara M, Sajewicz W.

Acta Pol Pharm. 2014 Mar-Apr;71(2):229-43. Review.

20.

GPCR profiling: from hits to leads and from genotype to phenotype.

Cvijic ME, Sum CS, Alt A, Zhang L.

Drug Discov Today Technol. 2015 Nov;18:30-7. doi: 10.1016/j.ddtec.2015.10.005. Epub 2015 Nov 6. Review.

PMID:
26723890

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