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IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.

Xiong Y, Pennini M, Vogel SN, Medvedev AE.

J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.


Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components.

Dobrovolskaia MA, Medvedev AE, Thomas KE, Cuesta N, Toshchakov V, Ren T, Cody MJ, Michalek SM, Rice NR, Vogel SN.

J Immunol. 2003 Jan 1;170(1):508-19.


Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling.

Wang J, Ma J, Charboneau R, Barke R, Roy S.

J Biol Chem. 2011 Mar 25;286(12):10225-32. doi: 10.1074/jbc.M110.188680. Epub 2011 Jan 18.


Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1.

Keck S, Freudenberg M, Huber M.

J Immunol. 2010 May 15;184(10):5809-18. doi: 10.4049/jimmunol.0901423. Epub 2010 Apr 12.


Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212.

Nahid MA, Yao B, Dominguez-Gutierrez PR, Kesavalu L, Satoh M, Chan EK.

J Immunol. 2013 Feb 1;190(3):1250-63. doi: 10.4049/jimmunol.1103060. Epub 2012 Dec 21.


IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B.

Over B, Ziegler S, Foermer S, Weber AN, Bode KA, Heeg K, Bekeredjian-Ding I.

Eur J Immunol. 2013 Jun;43(6):1630-42. doi: 10.1002/eji.201243217. Epub 2013 Apr 30.


Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20.

Xiong Y, Medvedev AE.

J Leukoc Biol. 2011 Dec;90(6):1141-8. doi: 10.1189/jlb.0611273. Epub 2011 Sep 20.


ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance.

Liu J, Buckley JM, Redmond HP, Wang JH.

J Immunol. 2010 May 15;184(10):5802-8. doi: 10.4049/jimmunol.0904127. Epub 2010 Apr 16.


Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss.

Papadopoulos G, Weinberg EO, Massari P, Gibson FC 3rd, Wetzler LM, Morgan EF, Genco CA.

J Immunol. 2013 Feb 1;190(3):1148-57. doi: 10.4049/jimmunol.1202511. Epub 2012 Dec 21.


Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways.

Zhang H, Kang L, Yao H, He Y, Wang X, Xu W, Song Z, Yin Y, Zhang X.

Front Cell Infect Microbiol. 2016 Feb 29;6:23. doi: 10.3389/fcimb.2016.00023. eCollection 2016.


Bruton's tyrosine kinase is required for TLR-induced IL-10 production.

Schmidt NW, Thieu VT, Mann BA, Ahyi AN, Kaplan MH.

J Immunol. 2006 Nov 15;177(10):7203-10.


The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.

Bafica A, Feng CG, Santiago HC, Aliberti J, Cheever A, Thomas KE, Taylor GA, Vogel SN, Sher A.

J Immunol. 2007 Oct 15;179(8):5514-22.


Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4.

Klein M, Obermaier B, Angele B, Pfister HW, Wagner H, Koedel U, Kirschning CJ.

J Infect Dis. 2008 Oct 1;198(7):1028-36. doi: 10.1086/591626.


IRAK4 in TLR/IL-1R signaling: possible clinical applications.

Li X.

Eur J Immunol. 2008 Mar;38(3):614-8. doi: 10.1002/eji.200838161.


Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner.

Turner JD, Langley RS, Johnston KL, Egerton G, Wanji S, Taylor MJ.

J Immunol. 2006 Jul 15;177(2):1240-9.

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