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Items: 1 to 20 of 98

1.

MEK1-RSK2 contributes to Hedgehog signaling by stabilizing GLI2 transcription factor and inhibiting ubiquitination.

Liu Z, Li T, Reinhold MI, Naski MC.

Oncogene. 2014 Jan 2;33(1):65-73. doi: 10.1038/onc.2012.544. Epub 2012 Dec 3.

PMID:
23208494
2.

Aldehyde dehydrogenase 1A1 stabilizes transcription factor Gli2 and enhances the activity of Hedgehog signaling in hepatocellular cancer.

Yan Z, Xu L, Zhang J, Lu Q, Luo S, Xu L.

Biochem Biophys Res Commun. 2016 Mar 18;471(4):466-73. doi: 10.1016/j.bbrc.2016.02.052. Epub 2016 Feb 16.

PMID:
26896768
3.

Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy.

Coni S, Antonucci L, D'Amico D, Di Magno L, Infante P, De Smaele E, Giannini G, Di Marcotullio L, Screpanti I, Gulino A, Canettieri G.

PLoS One. 2013 Jun 6;8(6):e65718. doi: 10.1371/journal.pone.0065718. Print 2013.

4.

Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth.

Lee MH, Huang Z, Kim DJ, Kim SH, Kim MO, Lee SY, Xie H, Park SJ, Kim JY, Kundu JK, Bode AM, Surh YJ, Dong Z.

Cancer Prev Res (Phila). 2013 May;6(5):455-65. doi: 10.1158/1940-6207.CAPR-12-0425. Epub 2013 Feb 27.

7.

Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway.

Cournoyer P, Desrosiers RR.

Neuropharmacology. 2009 Apr;56(5):839-48. doi: 10.1016/j.neuropharm.2009.01.008. Epub 2009 Jan 19.

PMID:
19371592
8.

Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells.

Doyon P, Servant MJ.

J Biol Chem. 2010 Oct 1;285(40):30708-18. doi: 10.1074/jbc.M110.126433. Epub 2010 Jul 21. Erratum in: J Biol Chem. 2011 Mar 25;286(12):10888.

9.

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.

Riobó NA, Lu K, Ai X, Haines GM, Emerson CP Jr.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4505-10. Epub 2006 Mar 10.

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Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts.

Takahashi-Yanaga F, Shiraishi F, Hirata M, Miwa Y, Morimoto S, Sasaguri T.

Biochem Biophys Res Commun. 2004 Apr 2;316(2):411-5.

PMID:
15020233
14.

Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium.

Chen Y, Yue S, Xie L, Pu XH, Jin T, Cheng SY.

J Biol Chem. 2011 Apr 15;286(15):13502-11. doi: 10.1074/jbc.M110.217604. Epub 2011 Feb 11.

15.

ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1.

Oh YT, Liu X, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY.

J Biol Chem. 2010 Dec 31;285(53):41310-9. doi: 10.1074/jbc.M110.153775. Epub 2010 Nov 2.

16.

FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.

Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J.

Cancer Cell. 2007 Sep;12(3):201-14.

17.

A new cellular signaling mechanism for angiotensin II activation of NF-kappaB: An IkappaB-independent, RSK-mediated phosphorylation of p65.

Zhang L, Ma Y, Zhang J, Cheng J, Du J.

Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1148-53. Epub 2005 Mar 31.

18.

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.

Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA.

Oncotarget. 2011 Aug;2(8):638-45.

19.

GLI2-mediated melanoma invasion and metastasis.

Alexaki VI, Javelaud D, Van Kempen LC, Mohammad KS, Dennler S, Luciani F, Hoek KS, Juàrez P, Goydos JS, Fournier PJ, Sibon C, Bertolotto C, Verrecchia F, Saule S, Delmas V, Ballotti R, Larue L, Saiag P, Guise TA, Mauviel A.

J Natl Cancer Inst. 2010 Aug 4;102(15):1148-59. doi: 10.1093/jnci/djq257. Epub 2010 Jul 21.

20.

Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.

Asaoka Y, Kanai F, Ichimura T, Tateishi K, Tanaka Y, Ohta M, Seto M, Tada M, Ijichi H, Ikenoue T, Kawabe T, Isobe T, Yaffe MB, Omata M.

J Biol Chem. 2010 Feb 5;285(6):4185-94. doi: 10.1074/jbc.M109.038232. Epub 2009 Dec 7.

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