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Items: 1 to 20 of 158

2.

Role of drug-independent stress factors in liver injury associated with diclofenac intake.

Ramm S, Mally A.

Toxicology. 2013 Oct 4;312:83-96. doi: 10.1016/j.tox.2013.08.002. Epub 2013 Aug 9. Erratum in: Toxicology. 2014 Feb 28;316:71-4.

PMID:
23939143
3.

Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.

Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.

Chem Res Toxicol. 1999 Feb;12(2):214-22.

PMID:
10027801
4.

Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine.

Zhu Y, Zhang QY.

J Pharmacol Exp Ther. 2012 Nov;343(2):362-70. doi: 10.1124/jpet.112.198077. Epub 2012 Aug 14.

5.

Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.

Dragovic S, Boerma JS, Vermeulen NP, Commandeur JN.

Chem Res Toxicol. 2013 Nov 18;26(11):1632-41. doi: 10.1021/tx400204d. Epub 2013 Nov 5.

PMID:
24083800
6.

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.

Drug Metab Dispos. 1999 Mar;27(3):365-72.

7.

Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.

Niu X, de Graaf IA, Langelaar-Makkinje M, Horvatovich P, Groothuis GM.

Arch Toxicol. 2015 Jan;89(1):107-19. doi: 10.1007/s00204-014-1242-6. Epub 2014 Apr 26.

PMID:
24770551
8.

Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.

den Braver MW, den Braver-Sewradj SP, Vermeulen NP, Commandeur JN.

Toxicol Lett. 2016 Jun 24;253:46-54. doi: 10.1016/j.toxlet.2016.04.022. Epub 2016 Apr 26.

PMID:
27130197
9.

Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1.

Boerma JS, Dragovic S, Vermeulen NP, Commandeur JN.

Chem Res Toxicol. 2012 Nov 19;25(11):2532-41. doi: 10.1021/tx300334w. Epub 2012 Oct 10.

PMID:
22998212
10.

The metabolism of diclofenac--enzymology and toxicology perspectives.

Tang W.

Curr Drug Metab. 2003 Aug;4(4):319-29. Review.

PMID:
12871048
11.

Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.

Deng X, Stachlewitz RF, Liguori MJ, Blomme EA, Waring JF, Luyendyk JP, Maddox JF, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2006 Dec;319(3):1191-9. Epub 2006 Sep 21.

12.

Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity.

Bort R, Ponsoda X, Jover R, Gómez-Lechón MJ, Castell JV.

J Pharmacol Exp Ther. 1999 Jan;288(1):65-72.

13.
14.

Effects of phenobarbital on metabolism and toxicity of diclofenac sodium in rat hepatocytes in vitro.

Wang AG, Xia T, Yuan J, Yu RA, Yang KD, Chen XM, Qu W, Waalkes MP.

Food Chem Toxicol. 2004 Oct;42(10):1647-53.

PMID:
15304311
15.

One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.

Boerma JS, Vermeulen NP, Commandeur JN.

Chem Biol Interact. 2014 Jan 25;207:32-40. doi: 10.1016/j.cbi.2013.11.001. Epub 2013 Nov 15.

PMID:
24246759
16.

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity.

Boelsterli UA.

Toxicol Appl Pharmacol. 2003 Nov 1;192(3):307-22. Review.

PMID:
14575648
17.

Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.

Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J.

Biochem Pharmacol. 1999 Sep 1;58(5):787-96.

PMID:
10449188
18.

Application of a discovery to targeted LC-MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration.

Ramm S, Morissey B, Hernandez B, Rooney C, Pennington SR, Mally A.

Toxicology. 2015 May 4;331:100-11. doi: 10.1016/j.tox.2015.03.004. Epub 2015 Mar 13.

PMID:
25772430
19.

Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid.

Miyamoto G, Zahid N, Uetrecht JP.

Chem Res Toxicol. 1997 Apr;10(4):414-9.

PMID:
9114978
20.

Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.

den Braver MW, Zhang Y, Venkataraman H, Vermeulen NP, Commandeur JN.

Toxicol Lett. 2016 Jul 25;255:52-62. doi: 10.1016/j.toxlet.2016.05.015. Epub 2016 May 13.

PMID:
27183920

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