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Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAs.

Chung AC, Dong Y, Yang W, Zhong X, Li R, Lan HY.

Mol Ther. 2013 Feb;21(2):388-98. doi: 10.1038/mt.2012.251. Epub 2012 Dec 4.


The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway.

Li R, Chung AC, Dong Y, Yang W, Zhong X, Lan HY.

Kidney Int. 2013 Dec;84(6):1129-44. doi: 10.1038/ki.2013.272. Epub 2013 Jul 17.


miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy.

Wang JY, Gao YB, Zhang N, Zou DW, Wang P, Zhu ZY, Li JY, Zhou SN, Wang SC, Wang YY, Yang JK.

Mol Cell Endocrinol. 2014 Jul 5;392(1-2):163-72. doi: 10.1016/j.mce.2014.05.018. Epub 2014 Jun 2.


Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.

Liu GX, Li YQ, Huang XR, Wei L, Chen HY, Shi YJ, Heuchel RL, Lan HY.

PLoS One. 2013;8(1):e53573. doi: 10.1371/journal.pone.0053573. Epub 2013 Jan 3.


Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension.

Liu GX, Li YQ, Huang XR, Wei LH, Zhang Y, Feng M, Meng XM, Chen HY, Shi YJ, Lan HY.

Clin Sci (Lond). 2014 Aug;127(3):195-208. doi: 10.1042/CS20130706.


miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7.

McClelland AD, Herman-Edelstein M, Komers R, Jha JC, Winbanks CE, Hagiwara S, Gregorevic P, Kantharidis P, Cooper ME.

Clin Sci (Lond). 2015 Dec;129(12):1237-49. doi: 10.1042/CS20150427. Epub 2015 Sep 28.


Diverse roles of TGF-β/Smads in renal fibrosis and inflammation.

Lan HY.

Int J Biol Sci. 2011;7(7):1056-67. Epub 2011 Sep 2. Review.


TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29.

Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ, Lan HY.

J Am Soc Nephrol. 2011 Aug;22(8):1462-74. doi: 10.1681/ASN.2010121308. Epub 2011 Jul 22.


Mir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7.

Yuan J, Chen H, Ge D, Xu Y, Xu H, Yang Y, Gu M, Zhou Y, Zhu J, Ge T, Chen Q, Gao Y, Wang Y, Li X, Zhao Y.

Cell Physiol Biochem. 2017;42(6):2207-2219. doi: 10.1159/000479995. Epub 2017 Aug 16.


miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling.

Zhang Y, Huang XR, Wei LH, Chung AC, Yu CM, Lan HY.

Mol Ther. 2014 May;22(5):974-85. doi: 10.1038/mt.2014.25. Epub 2014 Feb 26.


Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation.

Liu Z, Huang XR, Chen HY, Fung E, Liu J, Lan HY.

Hypertension. 2017 Oct;70(4):822-830. doi: 10.1161/HYPERTENSIONAHA.117.09600. Epub 2017 Aug 14.


The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential.

Chen HY, Huang XR, Wang W, Li JH, Heuchel RL, Chung AC, Lan HY.

Diabetes. 2011 Feb;60(2):590-601. doi: 10.2337/db10-0403. Epub 2010 Oct 27.


Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-β1/Smad3.

Liang C, Bu S, Fan X.

Cell Biochem Funct. 2016 Jul;34(5):326-33. doi: 10.1002/cbf.3193. Epub 2016 Jun 7.


miR-192 mediates TGF-beta/Smad3-driven renal fibrosis.

Chung AC, Huang XR, Meng X, Lan HY.

J Am Soc Nephrol. 2010 Aug;21(8):1317-25. doi: 10.1681/ASN.2010020134. Epub 2010 May 20.


Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3.

Yang F, Chung AC, Huang XR, Lan HY.

Hypertension. 2009 Oct;54(4):877-84. doi: 10.1161/HYPERTENSIONAHA.109.136531. Epub 2009 Aug 10.


miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes.

Zhong X, Chung AC, Chen HY, Dong Y, Meng XM, Li R, Yang W, Hou FF, Lan HY.

Diabetologia. 2013 Mar;56(3):663-74. doi: 10.1007/s00125-012-2804-x. Epub 2013 Jan 5.


TGF-beta1/Smad7 signaling stimulates renal tubulointerstitial fibrosis induced by AAI.

Wang Y, Zhang Z, Shen H, Lu Y, Li H, Ren X, Wu G.

J Recept Signal Transduct Res. 2008;28(4):413-28. doi: 10.1080/10799890802176741 .


Transforming growth factor-β/Smad signalling in diabetic nephropathy.

Lan HY.

Clin Exp Pharmacol Physiol. 2012 Aug;39(8):731-8. doi: 10.1111/j.1440-1681.2011.05663.x. Review.


Rapid atrial pacing induces myocardial fibrosis by down-regulating Smad7 via microRNA-21 in rabbit.

He X, Zhang K, Gao X, Li L, Tan H, Chen J, Zhou Y.

Heart Vessels. 2016 Oct;31(10):1696-708. doi: 10.1007/s00380-016-0808-z. Epub 2016 Mar 11.


Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model.

Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ.

J Am Soc Nephrol. 2003 Jun;14(6):1535-48.

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