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Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.

Yamaguchi Y, Shao Z, Sharif S, Du XY, Myles T, Merchant M, Harsh G, Glantz M, Recht L, Morser J, Leung LL.

J Biol Chem. 2013 Feb 1;288(5):3097-111. doi: 10.1074/jbc.M112.362954. Epub 2012 Nov 30.


Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis.

Sharif SA, Du X, Myles T, Song JJ, Price E, Lee DM, Goodman SB, Nagashima M, Morser J, Robinson WH, Leung LL.

Arthritis Rheum. 2009 Oct;60(10):2902-12. doi: 10.1002/art.24814.


Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D.

Christensen B, Schack L, Kläning E, Sørensen ES.

J Biol Chem. 2010 Mar 12;285(11):7929-37. doi: 10.1074/jbc.M109.075010. Epub 2010 Jan 13.


SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis.

Uchinaka A, Hamada Y, Mori S, Miyagawa S, Saito A, Sawa Y, Matsuura N, Yamamoto H, Kawaguchi N.

Mol Cell Biochem. 2015 Oct;408(1-2):191-203. doi: 10.1007/s11010-015-2495-y. Epub 2015 Jun 27.


Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1alpha in human glioma in vitro and in vivo.

Said HM, Hagemann C, Staab A, Stojic J, Kühnel S, Vince GH, Flentje M, Roosen K, Vordermark D.

Radiother Oncol. 2007 Jun;83(3):398-405. Epub 2007 May 23.


Osteopontin is highly susceptible to cleavage in bovine milk and the proteolytic fragments bind the αVβ₃-integrin receptor.

Christensen B, Sørensen ES.

J Dairy Sci. 2014;97(1):136-46. doi: 10.3168/jds.2013-7223. Epub 2013 Nov 21.


Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis.

Beausoleil MS, Schulze EB, Goodale D, Postenka CO, Allan AL.

BMC Cancer. 2011 Jan 19;11:25. doi: 10.1186/1471-2407-11-25.


Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells.

Yan W, Qian C, Zhao P, Zhang J, Shi L, Qian J, Liu N, Fu Z, Kang C, Pu P, You Y.

Neuro Oncol. 2010 Aug;12(8):765-75. doi: 10.1093/neuonc/noq006. Epub 2010 Feb 8.


Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer.

Shojaei F, Scott N, Kang X, Lappin PB, Fitzgerald AA, Karlicek S, Simmons BH, Wu A, Lee JH, Bergqvist S, Kraynov E.

J Exp Clin Cancer Res. 2012 Mar 23;31:26. doi: 10.1186/1756-9966-31-26.


Elevated levels of full-length and thrombin-cleaved osteopontin during acute dengue virus infection are associated with coagulation abnormalities.

Chagan-Yasutan H, Lacuesta TL, Ndhlovu LC, Oguma S, Leano PS, Telan EF, Kubo T, Morita K, Uede T, Dimaano EM, Hattori T.

Thromb Res. 2014 Aug;134(2):449-54. doi: 10.1016/j.thromres.2014.05.003. Epub 2014 May 14.


Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage.

Jürets A, Le Bras M, Staffler G, Stein G, Leitner L, Neuhofer A, Tardelli M, Turkof E, Zeyda M, Stulnig TM.

PLoS One. 2016 Feb 3;11(2):e0148333. doi: 10.1371/journal.pone.0148333. eCollection 2016.


Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicity in vivo.

Lamour V, Henry A, Kroonen J, Nokin MJ, von Marschall Z, Fisher LW, Chau TL, Chariot A, Sanson M, Delattre JY, Turtoi A, Peulen O, Rogister B, Castronovo V, Bellahcène A.

Int J Cancer. 2015 Sep 1;137(5):1047-57. doi: 10.1002/ijc.29454. Epub 2015 May 21.


Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site.

Nishimichi N, Higashikawa F, Kinoh HH, Tateishi Y, Matsuda H, Yokosaki Y.

J Biol Chem. 2009 May 29;284(22):14769-76. doi: 10.1074/jbc.M901515200. Epub 2009 Apr 3.


Osteopontin regulates human glioma cell invasiveness and tumor growth in mice.

Jan HJ, Lee CC, Shih YL, Hueng DY, Ma HI, Lai JH, Wei HW, Lee HM.

Neuro Oncol. 2010 Jan;12(1):58-70. doi: 10.1093/neuonc/nop013. Epub 2009 Dec 23.


Elevation of osteopontin levels in brain tumor cells reduces burden and promotes survival through the inhibition of cell dispersal.

Selkirk SM, Morrow J, Barone TA, Hoffer A, Lock J, DeChant A, Mangla S, Plunkett RJ, Miller RH.

J Neurooncol. 2008 Feb;86(3):285-96. Epub 2007 Oct 11.


The carboxyl-terminal fragment of osteopontin suppresses arginine-glycine-asparatic acid-dependent cell adhesion.

Takahashi K, Takahashi F, Tanabe KK, Takahashi H, Fukuchi Y.

Biochem Mol Biol Int. 1998 Dec;46(6):1081-92.


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