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Items: 1 to 20 of 95

1.

New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): general screening and toxicokinetic aspects of OP scavengers.

Müller S, Estour F, Kalakuntla RK, Le Provost R, Lafont O, Worek F, Thiermann H, Reiter G.

Toxicol Lett. 2013 Feb 4;216(2-3):206-12. doi: 10.1016/j.toxlet.2012.11.019. Epub 2012 Nov 29.

PMID:
23201438
2.

In vitro detoxification of cyclosarin (GF) by modified cyclodextrins.

Müller S, Koller M, Le Provost R, Lafont O, Estour F, Wille T, Thiermann H, Worek F, Reiter G.

Toxicol Lett. 2011 Jan 15;200(1-2):53-8. doi: 10.1016/j.toxlet.2010.10.014. Epub 2010 Oct 28.

PMID:
21035528
3.

Elimination pathways of cyclosarin (GF) mediated by β-cyclodextrin in vitro: pharmacokinetic and toxicokinetic aspects.

Kranawetvogl A, Schüler J, Müller S, Thiermann H, Worek F, Reiter G.

Toxicol Lett. 2013 Oct 24;222(2):164-70. doi: 10.1016/j.toxlet.2013.07.017. Epub 2013 Jul 29.

PMID:
23906718
4.

New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay.

Kalakuntla RK, Wille T, Le Provost R, Letort S, Reiter G, Müller S, Thiermann H, Worek F, Gouhier G, Lafont O, Estour F.

Toxicol Lett. 2013 Feb 4;216(2-3):200-5. doi: 10.1016/j.toxlet.2012.11.020. Epub 2012 Nov 29.

PMID:
23201439
5.

Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.

Wille T, Tenberken O, Reiter G, Müller S, Le Provost R, Lafont O, Estour F, Thiermann H, Worek F.

Toxicology. 2009 Nov 30;265(3):96-100. doi: 10.1016/j.tox.2009.09.018. Epub 2009 Oct 1.

PMID:
19800384
6.

Elimination kinetics and molecular reaction mechanisms of cyclosarin (GF) by an oxime substituted β-cyclodextrin derivative in vitro.

Kranawetvogl A, Müller S, Kubik S, Spruit H, Thiermann H, Worek F, Noort D, Reiter G.

Toxicol Lett. 2015 Nov 19;239(1):41-52. doi: 10.1016/j.toxlet.2015.08.007. Epub 2015 Aug 10.

PMID:
26272752
7.

Detoxification of alkyl methylphosphonofluoridates by an oxime-substituted β-cyclodextrin--an in vitro structure-activity study.

Bierwisch A, Zengerle M, Thiermann H, Kubik S, Worek F.

Toxicol Lett. 2014 Jan 13;224(2):209-14. doi: 10.1016/j.toxlet.2013.10.024. Epub 2013 Oct 31.

PMID:
24185128
8.

Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo.

Worek F, Seeger T, Zengerle M, Kubik S, Thiermann H, Wille T.

Toxicol Lett. 2014 Apr 21;226(2):222-7. doi: 10.1016/j.toxlet.2014.02.010. Epub 2014 Feb 20.

PMID:
24561299
9.

Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers.

Le Provost R, Wille T, Louise L, Masurier N, Müller S, Reiter G, Renard PY, Lafont O, Worek F, Estour F.

Org Biomol Chem. 2011 Apr 21;9(8):3026-32. doi: 10.1039/c0ob00931h. Epub 2011 Mar 4.

PMID:
21373706
10.

Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.

Aurbek N, Thiermann H, Eyer F, Eyer P, Worek F.

Toxicology. 2009 May 17;259(3):133-9. doi: 10.1016/j.tox.2009.02.014. Epub 2009 Mar 6.

PMID:
19428953
11.

Functionalized cyclodextrins bearing an alpha nucleophile--a promising way to degrade nerve agents.

Estour F, Letort S, Müller S, Kalakuntla RK, Le Provost R, Wille T, Reiter G, Worek F, Lafont O, Gouhier G.

Chem Biol Interact. 2013 Mar 25;203(1):202-7. doi: 10.1016/j.cbi.2012.10.020. Epub 2012 Nov 2.

PMID:
23123247
12.

In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP).

Wille T, Thiermann H, Worek F.

Arch Toxicol. 2014 Feb;88(2):301-7. doi: 10.1007/s00204-013-1130-5. Epub 2013 Sep 22.

PMID:
24057572
13.

Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase.

Aurbek N, Thiermann H, Szinicz L, Eyer P, Worek F.

Toxicology. 2006 Jul 5;224(1-2):91-9. Epub 2006 Apr 27.

PMID:
16720069
14.

Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups.

Brandhuber F, Zengerle M, Porwol L, Tenberken O, Thiermann H, Worek F, Kubik S, Reiter G.

Toxicology. 2012 Dec 16;302(2-3):163-71. doi: 10.1016/j.tox.2012.08.013. Epub 2012 Sep 11.

PMID:
22982866
16.

Development and application of procedures for the highly sensitive quantification of cyclosarin enantiomers in hemolysed swine blood samples.

Reiter G, Koller M, Thiermann H, Dorandeu F, Mikler J, Worek F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Nov 1;859(1):9-15. Epub 2007 Sep 6.

PMID:
17888747
18.

Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds.

Wille T, Ekström F, Lee JC, Pang YP, Thiermann H, Worek F.

Biochem Pharmacol. 2010 Sep 15;80(6):941-6. doi: 10.1016/j.bcp.2010.05.022. Epub 2010 May 26.

PMID:
20510679
19.

Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning.

Thiermann H, Szinicz L, Eyer P, Felgenhauer N, Zilker T, Worek F.

Toxicology. 2007 Apr 20;233(1-3):145-54. Epub 2006 Nov 19.

PMID:
17161895
20.

In vitro toxicokinetic studies of cyclosarin: molecular mechanisms of elimination.

Reiter G, Müller S, Koller M, Thiermann H, Worek F.

Toxicol Lett. 2014 May 16;227(1):1-11. doi: 10.1016/j.toxlet.2014.03.003. Epub 2014 Mar 16.

PMID:
24641973

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