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Items: 1 to 20 of 75

1.

Selectivity of kinases on the activation of tenofovir, an anti-HIV agent.

Varga A, Gráczer E, Chaloin L, Liliom K, Závodszky P, Lionne C, Vas M.

Eur J Pharm Sci. 2013 Jan 23;48(1-2):307-15. doi: 10.1016/j.ejps.2012.11.007. Epub 2012 Nov 28.

PMID:
23201309
2.

Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.

Frangeul A, Bussetta C, Deval J, Barral K, Alvarez K, Canard B.

Antivir Ther. 2008;13(1):115-24.

PMID:
18389906
3.

Nucleotide promiscuity of 3-phosphoglycerate kinase is in focus: implications for the design of better anti-HIV analogues.

Varga A, Chaloin L, Sági G, Sendula R, Gráczer E, Liliom K, Závodszky P, Lionne C, Vas M.

Mol Biosyst. 2011 Jun;7(6):1863-73. doi: 10.1039/c1mb05051f. Epub 2011 Apr 20.

PMID:
21505655
4.

Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: binding mode and phosphorylation of tenofovir derivatives.

Koch K, Chen Y, Feng JY, Borroto-Esoda K, Deville-Bonne D, Gallois-Montbrun S, Janin J, Moréra S.

Nucleosides Nucleotides Nucleic Acids. 2009 Aug;28(8):776-92. doi: 10.1080/15257770903155899. Erratum in: Nucleosides Nucleotides Nucleic Acids. 2009 Oct;28(10):987. Gallois-Montbrun, Sarah [added].

PMID:
20183617
5.

Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases.

Brown JA, Pack LR, Fowler JD, Suo Z.

Antimicrob Agents Chemother. 2011 Jan;55(1):276-83. doi: 10.1128/AAC.01229-10. Epub 2010 Nov 15.

6.

Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.

Ray AS, Vela JE, Boojamra CG, Zhang L, Hui H, Callebaut C, Stray K, Lin KY, Gao Y, Mackman RL, Cihlar T.

Antimicrob Agents Chemother. 2008 Feb;52(2):648-54. Epub 2007 Dec 3.

7.

Tenofovir disoproxil fumarate: a nucleotide reverse transcriptase inhibitor for the treatment of HIV infection.

Fung HB, Stone EA, Piacenti FJ.

Clin Ther. 2002 Oct;24(10):1515-48. Review.

PMID:
12462284
8.

Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases.

Chen Y, Gallois-Montbrun S, Schneider B, Véron M, Moréra S, Deville-Bonne D, Janin J.

J Mol Biol. 2003 Sep 26;332(4):915-26.

PMID:
12972261
9.

Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.

Cihlar T, Birkus G, Greenwalt DE, Hitchcock MJ.

Antiviral Res. 2002 Apr;54(1):37-45.

PMID:
11888656
10.
11.

Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.

Marchand B, White KL, Ly JK, Margot NA, Wang R, McDermott M, Miller MD, Götte M.

Antimicrob Agents Chemother. 2007 Aug;51(8):2911-9. Epub 2007 May 21.

12.
13.

Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection.

Antoniou T, Park-Wyllie LY, Tseng AL.

Pharmacotherapy. 2003 Jan;23(1):29-43. Review.

PMID:
12523458
14.

An introduction to nucleoside and nucleotide analogues.

Squires KE.

Antivir Ther. 2001;6 Suppl 3:1-14. Review.

PMID:
11678469
15.

Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*.

Birkus G, Hájek M, Kramata P, Votruba I, Holý A, Otová B.

Antimicrob Agents Chemother. 2002 May;46(5):1610-3.

17.

Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells.

Robbins BL, Wilcox CK, Fridland A, Rodman JH.

Pharmacotherapy. 2003 Jun;23(6):695-701.

PMID:
12820810
18.

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

Cihlar T, Ray AS, Boojamra CG, Zhang L, Hui H, Laflamme G, Vela JE, Grant D, Chen J, Myrick F, White KL, Gao Y, Lin KY, Douglas JL, Parkin NT, Carey A, Pakdaman R, Mackman RL.

Antimicrob Agents Chemother. 2008 Feb;52(2):655-65. Epub 2007 Dec 3.

19.

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.

Lade JM, To EE, Hendrix CW, Bumpus NN.

EBioMedicine. 2015 Jul 9;2(9):1145-52. doi: 10.1016/j.ebiom.2015.07.008. eCollection 2015 Sep.

20.

Role of nucleoside diphosphate kinase in the activation of anti-HIV nucleoside analogs.

Schneider B, Sarfati R, Deville-Bonne D, Véron M.

J Bioenerg Biomembr. 2000 Jun;32(3):317-24. Review.

PMID:
11768316

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