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Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung.

Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM.

Cell Rep. 2012 Dec 27;2(6):1762-73. doi: 10.1016/j.celrep.2012.10.026. Epub 2012 Nov 29.


Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection.

Jhingran A, Kasahara S, Shepardson KM, Junecko BA, Heung LJ, Kumasaka DK, Knoblaugh SE, Lin X, Kazmierczak BI, Reinhart TA, Cramer RA, Hohl TM.

PLoS Pathog. 2015 Jan 26;11(1):e1004589. doi: 10.1371/journal.ppat.1004589. eCollection 2015 Jan.


Activation of NF-κB and respiratory burst following Aspergillus fumigatus stimulation of macrophages.

Sun H, Xu XY, Tian XL, Shao HT, Wu XD, Wang Q, Su X, Shi Y.

Immunobiology. 2014 Jan;219(1):25-36. doi: 10.1016/j.imbio.2013.06.013. Epub 2013 Jul 4.


The adaptor molecule CARD9 is essential for tuberculosis control.

Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J, Kaufmann SH.

J Exp Med. 2010 Apr 12;207(4):777-92. doi: 10.1084/jem.20090067. Epub 2010 Mar 29.


Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display.

Hohl TM, Van Epps HL, Rivera A, Morgan LA, Chen PL, Feldmesser M, Pamer EG.

PLoS Pathog. 2005 Nov;1(3):e30. Epub 2005 Nov 18.


Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge.

Savers A, Rasid O, Parlato M, Brock M, Jouvion G, Ryffel B, Cavaillon JM, Eberl G, Ibrahim-Granet O.

PLoS One. 2016 Apr 14;11(4):e0153829. doi: 10.1371/journal.pone.0153829. eCollection 2016.


Early neutrophil recruitment and aggregation in the murine lung inhibit germination of Aspergillus fumigatus Conidia.

Bonnett CR, Cornish EJ, Harmsen AG, Burritt JB.

Infect Immun. 2006 Dec;74(12):6528-39. Epub 2006 Aug 18.


Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.

Werninghaus K, Babiak A, Gross O, Hölscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, Nimmerjahn F, Brown GD, Kirschning C, Heit A, Andersen P, Wagner H, Ruland J, Lang R.

J Exp Med. 2009 Jan 16;206(1):89-97. doi: 10.1084/jem.20081445. Epub 2009 Jan 12.


Inflammatory monocytes orchestrate innate antifungal immunity in the lung.

Espinosa V, Jhingran A, Dutta O, Kasahara S, Donnelly R, Du P, Rosenfeld J, Leiner I, Chen CC, Ron Y, Hohl TM, Rivera A.

PLoS Pathog. 2014 Feb 20;10(2):e1003940. doi: 10.1371/journal.ppat.1003940. eCollection 2014 Feb.


Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity.

Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner KP, Brombacher F, Urlaub H, Baier G, Brown GD, Leitges M, Ruland J.

Immunity. 2012 Jan 27;36(1):32-42. doi: 10.1016/j.immuni.2011.11.015.


Characterisation of innate fungal recognition in the lung.

Faro-Trindade I, Willment JA, Kerrigan AM, Redelinghuys P, Hadebe S, Reid DM, Srinivasan N, Wainwright H, Lang DM, Steele C, Brown GD.

PLoS One. 2012;7(4):e35675. doi: 10.1371/journal.pone.0035675. Epub 2012 Apr 20.


An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.

Yasukawa S, Miyazaki Y, Yoshii C, Nakaya M, Ozaki N, Toda S, Kuroda E, Ishibashi K, Yasuda T, Natsuaki Y, Mi-ichi F, Iizasa E, Nakahara T, Yamazaki M, Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, Hara H.

Nat Commun. 2014 May 7;5:3755. doi: 10.1038/ncomms4755.


Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.

Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gross O, Verbeek JS, Ruland J, Tybulewicz V, Brown GD, Moita LF, Taylor PR, Reis e Sousa C.

J Exp Med. 2009 Aug 31;206(9):2037-51. doi: 10.1084/jem.20082818. Epub 2009 Aug 24.


The immune interplay between the host and the pathogen in Aspergillus fumigatus lung infection.

Sales-Campos H, Tonani L, Cardoso CR, Kress MR.

Biomed Res Int. 2013;2013:693023. doi: 10.1155/2013/693023. Epub 2013 Jul 30. Review.


Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.

Uematsu T, Iizasa E, Kobayashi N, Yoshida H, Hara H.

Sci Rep. 2015 Dec 2;5:17577. doi: 10.1038/srep17577.


Aspergillus fumigatus conidial melanin modulates host cytokine response.

Chai LY, Netea MG, Sugui J, Vonk AG, van de Sande WW, Warris A, Kwon-Chung KJ, Kullberg BJ.

Immunobiology. 2010 Nov;215(11):915-20. doi: 10.1016/j.imbio.2009.10.002. Epub 2009 Nov 25.


Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition.

Wüthrich M, Wang H, Li M, Lerksuthirat T, Hardison SE, Brown GD, Klein B.

Eur J Immunol. 2015 Sep;45(9):2542-52. doi: 10.1002/eji.201545591. Epub 2015 Jul 28.


Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects.

Gazendam RP, van Hamme JL, Tool AT, Hoogenboezem M, van den Berg JM, Prins JM, Vitkov L, van de Veerdonk FL, van den Berg TK, Roos D, Kuijpers TW.

J Immunol. 2016 Feb 1;196(3):1272-83. doi: 10.4049/jimmunol.1501811. Epub 2015 Dec 30.


Characterisation of the phagocytic uptake of Aspergillus fumigatus conidia by macrophages.

Luther K, Rohde M, Sturm K, Kotz A, Heesemann J, Ebel F.

Microbes Infect. 2008 Feb;10(2):175-84. doi: 10.1016/j.micinf.2007.11.001. Epub 2007 Nov 17.


The serum opsonin L-ficolin is detected in lungs of human transplant recipients following fungal infections and modulates inflammation and killing of Aspergillus fumigatus.

Bidula S, Sexton DW, Abdolrasouli A, Shah A, Reed A, Armstrong-James D, Schelenz S.

J Infect Dis. 2015 Jul 15;212(2):234-46. doi: 10.1093/infdis/jiv027. Epub 2015 Jan 22.


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