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Items: 1 to 20 of 98

1.

Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonary hypertension.

Rafikova O, Rafikov R, Kumar S, Sharma S, Aggarwal S, Schneider F, Jonigk D, Black SM, Tofovic SP.

Free Radic Biol Med. 2013 Mar;56:28-43. doi: 10.1016/j.freeradbiomed.2012.09.013. Epub 2012 Nov 29.

2.

Rosuvastatin ameliorates the development of pulmonary arterial hypertension in the transgenic (mRen2)27 rat.

DeMarco VG, Habibi J, Whaley-Connell AT, Schneider RI, Sowers JR, Andresen BT, Gutweiler AA, Ma L, Johnson MS, Ferrario CM, Dellsperger KC.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1128-39. doi: 10.1152/ajpheart.00048.2009. Epub 2009 Jul 24.

3.

Endothelin-1-Rho kinase interactions impair lung structure and cause pulmonary hypertension after bleomycin exposure in neonatal rat pups.

Gien J, Tseng N, Seedorf G, Kuhn K, Abman SH.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1090-L1100. doi: 10.1152/ajplung.00066.2016. Epub 2016 Oct 19.

4.

Novel dual endothelin receptor antagonist macitentan reverses severe pulmonary arterial hypertension in rats.

Kunita-Takanezawa M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K.

J Cardiovasc Pharmacol. 2014 Nov;64(5):473-80. doi: 10.1097/FJC.0000000000000141.

PMID:
25084082
5.

The endothelin system in pulmonary arterial hypertension.

Galié N, Manes A, Branzi A.

Cardiovasc Res. 2004 Feb 1;61(2):227-37. Review.

PMID:
14736539
6.

Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats.

Matori H, Umar S, Nadadur RD, Sharma S, Partow-Navid R, Afkhami M, Amjedi M, Eghbali M.

Hypertension. 2012 Aug;60(2):425-30. doi: 10.1161/HYPERTENSIONAHA.112.191445. Epub 2012 Jul 2.

7.

Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.

Liu CP, Dai ZK, Huang CH, Yeh JL, Wu BN, Wu JR, Chen IJ.

Kaohsiung J Med Sci. 2014 Jun;30(6):267-78. doi: 10.1016/j.kjms.2014.02.014. Epub 2014 Apr 30.

8.

Bosentan attenuates right ventricular hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hypertension.

Choudhary G, Troncales F, Martin D, Harrington EO, Klinger JR.

J Heart Lung Transplant. 2011 Jul;30(7):827-33. doi: 10.1016/j.healun.2011.03.010. Epub 2011 May 8.

9.

The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension.

Fan YF, Zhang R, Jiang X, Wen L, Wu DC, Liu D, Yuan P, Wang YL, Jing ZC.

Cardiovasc Res. 2013 Aug 1;99(3):395-403. doi: 10.1093/cvr/cvt109. Epub 2013 May 6.

PMID:
23650288
10.

Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension.

Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA.

Circulation. 2012 Aug 21;126(8):963-74. doi: 10.1161/CIRCULATIONAHA.112.094722. Epub 2012 Jul 11.

11.

Intermedin modulates hypoxic pulmonary vascular remodeling by inhibiting pulmonary artery smooth muscle cell proliferation.

Mao SZ, Fan XF, Xue F, Chen R, Chen XY, Yuan GS, Hu LG, Liu SF, Gong YS.

Pulm Pharmacol Ther. 2014 Feb;27(1):1-9. doi: 10.1016/j.pupt.2013.06.004. Epub 2013 Jun 22.

PMID:
23796770
12.

Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide.

Black SM, Fineman JR.

Vascul Pharmacol. 2006 Nov;45(5):308-16. Epub 2006 Aug 18. Review.

PMID:
17049313
13.

2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats.

Tofovic SP, Zhang X, Jackson EK, Zhu H, Petrusevska G.

Vascul Pharmacol. 2009 Aug-Sep;51(2-3):190-7. doi: 10.1016/j.vph.2009.06.002. Epub 2009 Jun 21.

14.

Role of the endothelin system in secondary pulmonary hypertension related to air embolism: lessons learned from testing four classes of endothelin blockers in a rat model.

Battistini B, Verreault M, Ayach B, Blouin A, Cernacek P, Jeng AY, Wessale J, Opgenorth T, Tsang J.

J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S386-9.

PMID:
15838327
15.

Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats.

Chen SJ, Chen YF, Meng QC, Durand J, Dicarlo VS, Oparil S.

J Appl Physiol (1985). 1995 Dec;79(6):2122-31.

PMID:
8847282
16.

Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats.

Hill NS, Warburton RR, Pietras L, Klinger JR.

J Appl Physiol (1985). 1997 Oct;83(4):1209-15.

17.

Fasudil reversed MCT-induced and chronic hypoxia-induced pulmonary hypertension by attenuating oxidative stress and inhibiting the expression of Trx1 and HIF-1α.

Liu M, Wang Y, Zheng L, Zheng W, Dong K, Chen S, Zhang B, Li Z.

Respir Physiol Neurobiol. 2014 Sep 15;201:38-46. doi: 10.1016/j.resp.2014.06.001. Epub 2014 Jun 25.

PMID:
24973470
18.

Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension.

Mouchaers KT, Schalij I, Versteilen AM, Hadi AM, van Nieuw Amerongen GP, van Hinsbergh VW, Postmus PE, van der Laarse WJ, Vonk-Noordegraaf A.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H200-7. doi: 10.1152/ajpheart.00893.2008. Epub 2009 Apr 24.

19.

ZD1611, an orally active endothelin-A receptor antagonist, prevents chronic hypoxia-induced pulmonary hypertension in the rat.

Bialecki RA, Fisher CS, Abbott BM, Barthlow HG, Caccese RG, Stow RB, Rumsey J, Rumsey W.

Pulm Pharmacol Ther. 1999;12(5):303-12.

PMID:
10545286
20.

Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat.

DeMarco VG, Habibi J, Whaley-Connell AT, Schneider RI, Heller RL, Bosanquet JP, Hayden MR, Delcour K, Cooper SA, Andresen BT, Sowers JR, Dellsperger KC.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2659-68. doi: 10.1152/ajpheart.00953.2007. Epub 2008 Apr 18.

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