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Items: 1 to 20 of 145

1.

Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis.

Ehser J, Holdener M, Christen S, Bayer M, Pfeilschifter JM, Hintermann E, Bogdanos D, Christen U.

J Autoimmun. 2013 May;42:39-49. doi: 10.1016/j.jaut.2012.11.001.

PMID:
23200317
2.

Cytochrome P450 2D6 as a model antigen.

Christen U, Holdener M, Hintermann E.

Dig Dis. 2010;28(1):80-5. doi: 10.1159/000282068.

3.

Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6.

Hintermann E, Ehser J, Bayer M, Pfeilschifter JM, Christen U.

J Autoimmun. 2013 Aug;44:49-60. doi: 10.1016/j.jaut.2013.05.001.

PMID:
23809878
4.

Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model.

Hintermann E, Holdener M, Bayer M, Loges S, Pfeilschifter JM, Granier C, Manns MP, Christen U.

J Autoimmun. 2011 Nov;37(3):242-53. doi: 10.1016/j.jaut.2011.06.005.

PMID:
21795021
5.

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice.

Hintermann E, Ehser J, Christen U.

J Vis Exp. 2012 Feb 3;(60). pii: 3644. doi: 10.3791/3644.

6.

Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis.

Zierden M, Kühnen E, Odenthal M, Dienes HP.

Gastroenterology. 2010 Sep;139(3):975-86, 986.e1-3. doi: 10.1053/j.gastro.2010.05.075.

PMID:
20639127
7.

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection.

Holdener M, Hintermann E, Bayer M, Rhode A, Rodrigo E, Hintereder G, Johnson EF, Gonzalez FJ, Pfeilschifter J, Manns MP, Herrath Mv, Christen U.

J Exp Med. 2008 Jun 9;205(6):1409-22. doi: 10.1084/jem.20071859.

8.

Aetiopathogenesis of autoimmune hepatitis.

Longhi MS, Ma Y, Mieli-Vergani G, Vergani D.

J Autoimmun. 2010 Feb;34(1):7-14. doi: 10.1016/j.jaut.2009.08.010. Review.

PMID:
19766456
9.

A murine model of type 2 autoimmune hepatitis: Xenoimmunization with human antigens.

Lapierre P, Djilali-Saiah I, Vitozzi S, Alvarez F.

Hepatology. 2004 Apr;39(4):1066-74.

PMID:
15057911
10.

Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis.

Longhi MS, Hussain MJ, Kwok WW, Mieli-Vergani G, Ma Y, Vergani D.

Hepatology. 2011 Feb;53(2):536-47. doi: 10.1002/hep.24039.

PMID:
21274874
12.

A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens.

Sugimura T, Obermayer-Straub P, Kayser A, Braun S, Loges S, Alex B, Lüttig B, Johnson EF, Manns MP, Strassburg CP.

Autoimmunity. 2002 Dec;35(8):501-13.

PMID:
12765476
13.

Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.

Müller P, Messmer M, Bayer M, Pfeilschifter JM, Hintermann E, Christen U.

J Autoimmun. 2016 May;69:51-8. doi: 10.1016/j.jaut.2016.02.007.

PMID:
26924542
14.

Adaptive immunity in autoimmune hepatitis.

Longhi MS, Ma Y, Mieli-Vergani G, Vergani D.

Dig Dis. 2010;28(1):63-9. doi: 10.1159/000282066. Review.

PMID:
20460892
15.

New animal models for autoimmune hepatitis.

Christen U, Hintermann E, Jaeckel E.

Semin Liver Dis. 2009 Aug;29(3):262-72. doi: 10.1055/s-0029-1233536. Review.

PMID:
19675999
16.

Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis.

Mix H, Weiler-Normann C, Thimme R, Ahlenstiel G, Shin EC, Herkel J, David CS, Lohse AW, Rehermann B.

Gastroenterology. 2008 Dec;135(6):2107-18. doi: 10.1053/j.gastro.2008.07.029.

17.

Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease.

Kerkar N, Choudhuri K, Ma Y, Mahmoud A, Bogdanos DP, Muratori L, Bianchi F, Williams R, Mieli-Vergani G, Vergani D.

J Immunol. 2003 Feb 1;170(3):1481-9.

19.

Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2.

Ma Y, Bogdanos DP, Hussain MJ, Underhill J, Bansal S, Longhi MS, Cheeseman P, Mieli-Vergani G, Vergani D.

Gastroenterology. 2006 Mar;130(3):868-82.

PMID:
16530525
20.

Different sites of xenoantigen delivery lead to a virally induced late-onset hepatitis in mice through molecular mimicry.

Piché C, Béland K, Lapierre P, Massie B, Alvarez F.

Liver Int. 2011 Oct;31(9):1306-14. doi: 10.1111/j.1478-3231.2011.02600.x.

PMID:
22093453
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