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Items: 1 to 20 of 119

1.

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes.

Wong BW, Kuchnio A, Bruning U, Carmeliet P.

Trends Biochem Sci. 2013 Jan;38(1):3-11. doi: 10.1016/j.tibs.2012.10.004. Epub 2012 Nov 28. Review.

PMID:
23200187
2.

Role and regulation of prolyl hydroxylase domain proteins.

Fong GH, Takeda K.

Cell Death Differ. 2008 Apr;15(4):635-41. doi: 10.1038/cdd.2008.10. Epub 2008 Feb 15. Review.

3.

Oxygen sensing in Drosophila: multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFalpha/Sima.

Acevedo JM, Centanin L, Dekanty A, Wappner P.

PLoS One. 2010 Aug 25;5(8):e12390. doi: 10.1371/journal.pone.0012390.

4.
5.

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

Berchner-Pfannschmidt U, Yamac H, Trinidad B, Fandrey J.

J Biol Chem. 2007 Jan 19;282(3):1788-96. Epub 2006 Oct 23.

6.

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.

EMBO J. 2003 Aug 15;22(16):4082-90.

7.

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.

Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R.

J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76. doi: 10.1242/jcs.109041. Epub 2012 Sep 3.

8.

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability.

Barth S, Nesper J, Hasgall PA, Wirthner R, Nytko KJ, Edlich F, Katschinski DM, Stiehl DP, Wenger RH, Camenisch G.

Mol Cell Biol. 2007 May;27(10):3758-68. Epub 2007 Mar 12.

9.

HIF prolyl-4-hydroxylase interacting proteins: consequences for drug targeting.

Wenger RH, Camenisch G, Stiehl DP, Katschinski DM.

Curr Pharm Des. 2009;15(33):3886-94. Review.

PMID:
19671040
10.

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.

Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ.

Structure. 2009 Jul 15;17(7):981-9. doi: 10.1016/j.str.2009.06.002.

11.

The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3.

Jaakkola PM, Rantanen K.

Biol Chem. 2013 Apr;394(4):449-57. doi: 10.1515/hsz-2012-0330. Review.

PMID:
23380539
12.

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system.

Stiehl DP, Wirthner R, Köditz J, Spielmann P, Camenisch G, Wenger RH.

J Biol Chem. 2006 Aug 18;281(33):23482-91. Epub 2006 Jun 21.

13.

Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance.

Kasiganesan H, Sridharan V, Wright G.

Acta Physiol (Oxf). 2007 Jun;190(2):163-9. Epub 2007 Mar 30.

PMID:
17394573
14.

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.

Berra E, Ginouvès A, Pouysségur J.

EMBO Rep. 2006 Jan;7(1):41-5. Review.

15.

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.

Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J.

J Cell Sci. 2003 Apr 1;116(Pt 7):1319-26.

16.

HIF-prolyl hydroxylases and cardiovascular diseases.

Sen Banerjee S, Thirunavukkarasu M, Tipu Rishi M, Sanchez JA, Maulik N, Maulik G.

Toxicol Mech Methods. 2012 Jun;22(5):347-58. doi: 10.3109/15376516.2012.673088. Review.

PMID:
22424133
17.

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Pappalardi MB, McNulty DE, Martin JD, Fisher KE, Jiang Y, Burns MC, Zhao H, Ho T, Sweitzer S, Schwartz B, Annan RS, Copeland RA, Tummino PJ, Luo L.

Biochem J. 2011 Jun 1;436(2):363-9. doi: 10.1042/BJ20101201.

PMID:
21410436
18.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM.

J Biol Chem. 2004 Sep 10;279(37):38458-65. Epub 2004 Jul 7.

19.

Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

Martin F, Linden T, Katschinski DM, Oehme F, Flamme I, Mukhopadhyay CK, Eckhardt K, Tröger J, Barth S, Camenisch G, Wenger RH.

Blood. 2005 Jun 15;105(12):4613-9. Epub 2005 Mar 1.

20.

Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2.

Nandal A, Ruiz JC, Subramanian P, Ghimire-Rijal S, Sinnamon RA, Stemmler TL, Bruick RK, Philpott CC.

Cell Metab. 2011 Nov 2;14(5):647-57. doi: 10.1016/j.cmet.2011.08.015.

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