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Items: 1 to 20 of 155

1.

Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling.

Matarazzo V, Schaller F, Nédélec E, Benani A, Pénicaud L, Muscatelli F, Moyse E, Bauer S.

J Neurosci. 2012 Nov 28;32(48):17097-107. doi: 10.1523/JNEUROSCI.1669-12.2012.

2.

Leptin action in the forebrain regulates the hindbrain response to satiety signals.

Morton GJ, Blevins JE, Williams DL, Niswender KD, Gelling RW, Rhodes CJ, Baskin DG, Schwartz MW.

J Clin Invest. 2005 Mar;115(3):703-10.

3.

Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin.

Williams DL, Baskin DG, Schwartz MW.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1238-46. doi: 10.1152/ajpregu.00182.2009. Epub 2009 Sep 2.

4.

Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balance.

de Backer MW, Brans MA, van Rozen AJ, van der Zwaal EM, Luijendijk MC, Garner KG, de Krom M, van Beekum O, la Fleur SE, Adan RA.

J Mol Endocrinol. 2010 Nov;45(5):341-53. doi: 10.1677/JME-10-0057. Epub 2010 Sep 6.

PMID:
20819948
5.

Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling.

Metlakunta AS, Sahu M, Yasukawa H, Dhillon SS, Belsham DD, Yoshimura A, Sahu A.

Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1185-93. doi: 10.1152/ajpregu.00794.2010. Epub 2011 Feb 16.

6.

SOCS3 expression within leptin receptor-expressing cells regulates food intake and leptin sensitivity but does not affect weight gain in pregnant mice consuming a high-fat diet.

Zampieri TT, da Silva TE, de Paula Romeu D, Torrão AS, Donato J Jr.

Physiol Behav. 2016 Apr 1;157:109-15. doi: 10.1016/j.physbeh.2016.01.039. Epub 2016 Jan 28.

PMID:
26828039
7.

Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.

Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG Jr, Xu AW.

Diabetes. 2010 Apr;59(4):894-906. doi: 10.2337/db09-1024. Epub 2010 Jan 12.

8.

Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.

Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS.

Endocrinology. 2008 Nov;149(11):5654-61. doi: 10.1210/en.2008-0805. Epub 2008 Jul 31.

9.

Leptin signaling in the hypothalamus during chronic central leptin infusion.

Pal R, Sahu A.

Endocrinology. 2003 Sep;144(9):3789-98.

PMID:
12933650
10.

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT.

J Neurosci. 2009 Sep 16;29(37):11582-93. doi: 10.1523/JNEUROSCI.5712-08.2009.

11.

Phosphodiesterase-3B-cAMP pathway of leptin signalling in the hypothalamus is impaired during the development of diet-induced obesity in FVB/N mice.

Sahu M, Anamthathmakula P, Sahu A.

J Neuroendocrinol. 2015 Apr;27(4):293-302. doi: 10.1111/jne.12266.

PMID:
25702569
12.

Lentiviral vector-mediated knockdown of SOCS3 in the hypothalamus protects against the development of diet-induced obesity in rats.

Liu ZJ, Bian J, Zhao YL, Zhang X, Zou N, Li D.

Diabetes Obes Metab. 2011 Oct;13(10):885-92. doi: 10.1111/j.1463-1326.2011.01419.x.

PMID:
21554522
13.

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.

Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A.

Nat Med. 2004 Jul;10(7):739-43. Epub 2004 Jun 20.

PMID:
15208705
14.

Combined parental obesity augments single-parent obesity effects on hypothalamus inflammation, leptin signaling (JAK/STAT), hyperphagia, and obesity in the adult mice offspring.

Ornellas F, Souza-Mello V, Mandarim-de-Lacerda CA, Aguila MB.

Physiol Behav. 2016 Jan 1;153:47-55. doi: 10.1016/j.physbeh.2015.10.019. Epub 2015 Oct 17.

PMID:
26485293
15.

Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size.

Blevins JE, Schwartz MW, Baskin DG.

Am J Physiol Regul Integr Comp Physiol. 2004 Jul;287(1):R87-96. Epub 2004 Mar 25.

16.

Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3).

Yang Z, Hulver M, McMillan RP, Cai L, Kershaw EE, Yu L, Xue B, Shi H.

PLoS One. 2012;7(10):e47493. doi: 10.1371/journal.pone.0047493. Epub 2012 Oct 24.

17.

Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation.

Heldsinger A, Grabauskas G, Wu X, Zhou S, Lu Y, Song I, Owyang C.

Endocrinology. 2014 Oct;155(10):3956-69. doi: 10.1210/en.2013-2095. Epub 2014 Jul 25.

18.

Deletion of Suppressor of Cytokine Signaling 3 from Forebrain Neurons Delays Infertility and Onset of Hypothalamic Leptin Resistance in Response to a High Caloric Diet.

McEwen HJ, Inglis MA, Quennell JH, Grattan DR, Anderson GM.

J Neurosci. 2016 Jul 6;36(27):7142-53. doi: 10.1523/JNEUROSCI.2714-14.2016.

19.

Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance.

You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C, Liu Y.

Mol Cell Biol. 2010 Apr;30(7):1650-9. doi: 10.1128/MCB.01307-09. Epub 2010 Jan 19.

20.

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

Dunn SL, Björnholm M, Bates SH, Chen Z, Seifert M, Myers MG Jr.

Mol Endocrinol. 2005 Apr;19(4):925-38. Epub 2004 Dec 16.

PMID:
15604114

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