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Items: 1 to 20 of 92

1.

Development, validation and use of ELISA for antibodies to human alpha-1 antitrypsin.

Ye GJ, Oshins RA, Rouhani FN, Brantly ML, Chulay JD.

J Immunol Methods. 2013 Feb 28;388(1-2):18-24. doi: 10.1016/j.jim.2012.11.008. Epub 2012 Nov 27.

PMID:
23195820
2.

Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.

Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, Campbell-Thompson M, Yachnis AT, Sandhaus RA, McElvaney NG, Mueller C, Messina LM, Wilson JM, Brantly M, Knop DR, Ye GJ, Chulay JD.

Hum Gene Ther. 2011 Oct;22(10):1239-47. doi: 10.1089/hum.2011.053. Epub 2011 Aug 24.

3.

Immunohistochemical and genetic characterization of the M Cagliari alpha-1-antitrypsin molecule (M-like alpha-1-antitrypsin deficiency).

Sergi C, Consalez GG, Fabbretti G, Brisigotti M, Faa G, Costa V, Romeo G, Callea F.

Lab Invest. 1994 Jan;70(1):130-3.

PMID:
8302013
4.

Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults.

Brantly ML, Spencer LT, Humphries M, Conlon TJ, Spencer CT, Poirier A, Garlington W, Baker D, Song S, Berns KI, Muzyczka N, Snyder RO, Byrne BJ, Flotte TR.

Hum Gene Ther. 2006 Dec;17(12):1177-86.

PMID:
17115945
5.

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.

Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16363-8. doi: 10.1073/pnas.0904514106. Epub 2009 Aug 12. Erratum in: Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17606.

6.

Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.

Lu Y, Choi YK, Campbell-Thompson M, Li C, Tang Q, Crawford JM, Flotte TR, Song S.

J Gene Med. 2006 Jun;8(6):730-5.

PMID:
16518879
7.

In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA.

Cruz PE, Mueller C, Cossette TL, Golant A, Tang Q, Beattie SG, Brantly M, Campbell-Thompson M, Blomenkamp KS, Teckman JH, Flotte TR.

Lab Invest. 2007 Sep;87(9):893-902. Epub 2007 Jun 25.

8.

Evaluation of an immunoassay for human-specific quantitation of therapeutic antibodies in serum samples from non-human primates.

Stubenrauch K, Wessels U, Lenz H.

J Pharm Biomed Anal. 2009 May 1;49(4):1003-8. doi: 10.1016/j.jpba.2009.01.030. Epub 2009 Feb 5.

PMID:
19250787
9.

Evaluation of a generic immunoassay with drug tolerance to detect immune complexes in serum samples from cynomolgus monkeys after administration of human antibodies.

Stubenrauch K, Wessels U, Essig U, Vogel R, Schleypen J.

J Pharm Biomed Anal. 2010 Jun 5;52(2):249-54. doi: 10.1016/j.jpba.2009.12.029. Epub 2010 Jan 4.

PMID:
20083366
10.

Detection of circulating and endothelial cell polymers of Z and wild type alpha 1-antitrypsin by a monoclonal antibody.

Janciauskiene S, Dominaitiene R, Sternby NH, Piitulainen E, Eriksson S.

J Biol Chem. 2002 Jul 19;277(29):26540-6. Epub 2002 May 22.

11.

Identification of natural antibodies to interleukin-18 in the sera of normal humans and three nonhuman primate species.

Soos JM, Polsky RM, Keegan SP, Bugelski P, Herzyk DJ.

Clin Immunol. 2003 Nov;109(2):188-96.

PMID:
14597217
12.

Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults.

Flotte TR, Brantly ML, Spencer LT, Byrne BJ, Spencer CT, Baker DJ, Humphries M.

Hum Gene Ther. 2004 Jan;15(1):93-128.

PMID:
14965381
13.

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8.

Bergin DA, Reeves EP, Meleady P, Henry M, McElvaney OJ, Carroll TP, Condron C, Chotirmall SH, Clynes M, O'Neill SJ, McElvaney NG.

J Clin Invest. 2010 Dec;120(12):4236-50. doi: 10.1172/JCI41196. Epub 2010 Nov 8.

14.

Lack of association between hemochromatosis and alpha-antitrypsin deficiency.

Eriksson S, Lindmark B, Olsson S.

Acta Med Scand. 1986;219(3):291-4.

PMID:
3486552
15.

Development and evaluation of an ELISA for quantification of human alpha-1-proteinase inhibitor in complex biological mixtures.

Karnaukhova E, Golding B, Ophir Y.

Biologicals. 2007 Oct;35(4):285-95. Epub 2007 Jan 24.

PMID:
17257853
16.

Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors.

Song S, Morgan M, Ellis T, Poirier A, Chesnut K, Wang J, Brantly M, Muzyczka N, Byrne BJ, Atkinson M, Flotte TR.

Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14384-8.

17.

Development of an enzyme-linked immunosorbent assay with a monoclonal antibody prepared against alpha 1-antitrypsin for diagnostic screening of inflammatory disorders.

Silvestrini B, Guglielmotti A, Saso L, Milanese C, Melanitou E, Grima J, Cheng CY.

Clin Chem. 1990 Feb;36(2):277-82.

18.

Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice.

Song S, Goudy K, Campbell-Thompson M, Wasserfall C, Scott-Jorgensen M, Wang J, Tang Q, Crawford JM, Ellis TM, Atkinson MA, Flotte TR.

Gene Ther. 2004 Jan;11(2):181-6.

PMID:
14712302
19.

Augmentation therapy for emphysema due to alpha-1-antitrypsin deficiency.

Tirado-Conde G, Lara B, Miravitlles M.

Ther Adv Respir Dis. 2008 Feb;2(1):13-21. doi: 10.1177/1753465807088159. Review.

PMID:
19124355
20.

Gene therapy progress and prospects: alpha-1 antitrypsin.

Stecenko AA, Brigham KL.

Gene Ther. 2003 Jan;10(2):95-9. Review.

PMID:
12571637

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