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Items: 1 to 20 of 60

1.

The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving TLR/MyD88 and NF-κB/MAPK activation.

Daddaoua A, Martínez-Plata E, Ortega-González M, Ocón B, Aranda CJ, Zarzuelo A, Suárez MD, de Medina FS, Martínez-Augustin O.

Food Chem. 2013 Feb 15;136(3-4):1288-95. doi: 10.1016/j.foodchem.2012.09.039. Epub 2012 Sep 23.

PMID:
23194525
2.

Nondigestible oligosaccharides exert nonprebiotic effects on intestinal epithelial cells enhancing the immune response via activation of TLR4-NFκB.

Ortega-González M, Ocón B, Romero-Calvo I, Anzola A, Guadix E, Zarzuelo A, Suárez MD, Sánchez de Medina F, Martínez-Augustin O.

Mol Nutr Food Res. 2014 Feb;58(2):384-93. doi: 10.1002/mnfr.201300296. Epub 2013 Sep 3.

PMID:
24039030
3.

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways.

Gorina R, Font-Nieves M, Márquez-Kisinousky L, Santalucia T, Planas AM.

Glia. 2011 Feb;59(2):242-55. doi: 10.1002/glia.21094.

PMID:
21125645
4.

Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression.

Tomosada Y, Villena J, Murata K, Chiba E, Shimazu T, Aso H, Iwabuchi N, Xiao JZ, Saito T, Kitazawa H.

PLoS One. 2013;8(3):e59259. doi: 10.1371/journal.pone.0059259. Epub 2013 Mar 26.

5.

Active Hexose Correlated Compound (AHCC) promotes an intestinal immune response in BALB/c mice and in primary intestinal epithelial cell culture involving toll-like receptors TLR-2 and TLR-4.

Mallet JF, Graham É, Ritz BW, Homma K, Matar C.

Eur J Nutr. 2016 Feb;55(1):139-46. doi: 10.1007/s00394-015-0832-2. Epub 2015 Jan 18.

PMID:
25596849
6.

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.

J Pineal Res. 2012 Nov;53(4):325-34. doi: 10.1111/j.1600-079X.2012.01002.x. Epub 2012 Apr 27.

PMID:
22537289
7.

The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors.

Faisal A, Saurin A, Gregory B, Foxwell B, Parker PJ.

J Biol Chem. 2008 Jul 4;283(27):18591-600. doi: 10.1074/jbc.M710330200. Epub 2008 May 5.

8.

Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids.

Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, Hwang DH.

J Biol Chem. 2003 Sep 26;278(39):37041-51. Epub 2003 Jul 15.

9.

Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages.

Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X.

J Immunol. 2010 Jun 1;184(11):6447-56. doi: 10.4049/jimmunol.0901750. Epub 2010 Apr 30.

10.
11.

Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo.

Zhou L, Liu Z, Wang Z, Yu S, Long T, Zhou X, Bao Y.

Sci Rep. 2017 Mar 17;7:44822. doi: 10.1038/srep44822.

12.

The mechanism of LPS-induced HIV type I activation in transgenic mouse macrophages.

Kadoki M, Choi BI, Iwakura Y.

Int Immunol. 2010 Jun;22(6):469-78. doi: 10.1093/intimm/dxq032. Epub 2010 May 26.

PMID:
20504885
13.

MyD88-dependent Toll-like receptor signaling is required for murine macrophages response to IS2.

Li H, Kim WJ, Jiang J, Lee SH, Youn HS, Moon EY, Kim TJ, Ye SK, Ryu JH, Kang TB, Koppula S, Park PJ, Choi DK, Lee KH.

Int Immunopharmacol. 2011 Oct;11(10):1578-83. doi: 10.1016/j.intimp.2011.05.017. Epub 2011 May 31.

PMID:
21628003
14.

Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappaB and -MAPK signaling pathways.

Yokoyama T, Komori A, Nakamura M, Takii Y, Kamihira T, Shimoda S, Mori T, Fujiwara S, Koyabu M, Taniguchi K, Fujioka H, Migita K, Yatsuhashi H, Ishibashi H.

Liver Int. 2006 May;26(4):467-76.

PMID:
16629651
15.

Active hexose correlated compound inhibits the expression of proinflammatory biomarker iNOS in hepatocytes.

Matsui K, Ozaki T, Oishi M, Tanaka Y, Kaibori M, Nishizawa M, Okumura T, Kwon AH.

Eur Surg Res. 2011;47(4):274-83. doi: 10.1159/000333833. Epub 2011 Nov 10.

PMID:
22076046
16.

A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages.

Chang HH, Yeh CH, Sheu F.

J Agric Food Chem. 2009 Jul 22;57(14):6129-39. doi: 10.1021/jf9011399.

PMID:
19548679
17.

GEF-H1-RhoA signaling pathway mediates LPS-induced NF-κB transactivation and IL-8 synthesis in endothelial cells.

Guo F, Tang J, Zhou Z, Dou Y, Van Lonkhuyzen D, Gao C, Huan J.

Mol Immunol. 2012 Feb;50(1-2):98-107. doi: 10.1016/j.molimm.2011.12.009. Epub 2012 Jan 4.

PMID:
22226472
18.

DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway.

Cong L, Yang S, Zhang Y, Cao J, Fu X.

Int J Mol Med. 2018 May;41(5):2619-2628. doi: 10.3892/ijmm.2018.3511. Epub 2018 Feb 23.

19.

The non-proteolytic house dust mite allergen Der p 2 induce NF-kappaB and MAPK dependent activation of bronchial epithelial cells.

Osterlund C, Grönlund H, Polovic N, Sundström S, Gafvelin G, Bucht A.

Clin Exp Allergy. 2009 Aug;39(8):1199-208. doi: 10.1111/j.1365-2222.2009.03284.x. Epub 2009 May 26.

PMID:
19486032

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