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Items: 1 to 20 of 676

1.

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.

Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F.

J Biol Chem. 2013 Feb 1;288(5):2976-85. doi: 10.1074/jbc.M112.430066. Epub 2012 Nov 26.

2.

Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1, Smad5, and Smad6--modeling and analysis.

Sangadala S, Metpally RP, Reddy BV.

J Biomol Struct Dyn. 2007 Aug;25(1):11-23.

PMID:
17676934
3.

F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.

Li D, Xie P, Zhao F, Shu J, Li L, Zhan Y, Zhang L.

Biochem Biophys Res Commun. 2015 Mar 20;458(4):941-5. doi: 10.1016/j.bbrc.2015.02.089. Epub 2015 Feb 24.

PMID:
25721664
4.

Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells.

Xie P, Tang Y, Shen S, Wang Y, Xing G, Yin Y, He F, Zhang L.

Biochem Biophys Res Commun. 2011 Apr 1;407(1):254-9. doi: 10.1016/j.bbrc.2011.03.016. Epub 2011 Mar 5.

PMID:
21382345
5.

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L.

EMBO J. 2011 May 13;30(13):2675-89. doi: 10.1038/emboj.2011.155. Erratum in: EMBO J. 2011;30(13):2748.

6.

Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.

Li S, Lu K, Wang J, An L, Yang G, Chen H, Cui Y, Yin X, Xie P, Xing G, He F, Zhang L.

Mol Cell Biochem. 2010 May;338(1-2):11-7. doi: 10.1007/s11010-009-0315-y. Epub 2009 Nov 24.

PMID:
19937093
7.

Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.

Thompson JW, Nagel J, Hoving S, Gerrits B, Bauer A, Thomas JR, Kirschner MW, Schirle M, Luchansky SJ.

J Biol Chem. 2014 Oct 17;289(42):28942-55. doi: 10.1074/jbc.M114.573352. Epub 2014 Aug 21.

8.

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.

Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T.

J Biol Chem. 2008 Dec 19;283(51):35660-7. doi: 10.1074/jbc.M710496200. Epub 2008 Oct 16.

9.

Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays.

Andrews PS, Schneider S, Yang E, Michaels M, Chen H, Tang J, Emkey R.

Assay Drug Dev Technol. 2010 Aug;8(4):471-87. doi: 10.1089/adt.2009.0264.

PMID:
20804422
10.

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.

Lin Q, Wang J, Childress C, Sudol M, Carey DJ, Yang W.

Mol Cell Biol. 2010 Mar;30(6):1541-54. doi: 10.1128/MCB.00013-10. Epub 2010 Jan 19.

11.

The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein.

Du JX, Hagos EG, Nandan MO, Bialkowska AB, Yu B, Yang VW.

J Biol Chem. 2011 Nov 18;286(46):40354-64. doi: 10.1074/jbc.M111.258707. Epub 2011 Sep 27.

12.

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.

Morén A, Imamura T, Miyazono K, Heldin CH, Moustakas A.

J Biol Chem. 2005 Jun 10;280(23):22115-23. Epub 2005 Apr 6.

13.

Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.

Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.

J Biol Chem. 2010 Jul 23;285(30):22818-30. doi: 10.1074/jbc.M110.126920. Epub 2010 May 18.

14.

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1.

Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L, He F.

Nat Cell Biol. 2008 Aug;10(8):994-1002. doi: 10.1038/ncb1760. Epub 2008 Jul 20. Erratum in: Nat Cell Biol. 2010 Jun;12(6):625.

PMID:
18641638
15.

Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity.

Tian M, Bai C, Lin Q, Lin H, Liu M, Ding F, Wang HR.

FEBS Lett. 2011 Jul 21;585(14):2199-204. doi: 10.1016/j.febslet.2011.06.016. Epub 2011 Jun 23.

16.

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction.

Gomez-Bougie P, Ménoret E, Juin P, Dousset C, Pellat-Deceunynck C, Amiot M.

Biochem Biophys Res Commun. 2011 Sep 30;413(3):460-4. doi: 10.1016/j.bbrc.2011.08.118. Epub 2011 Sep 1.

PMID:
21907705
17.

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.

Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D.

J Biol Chem. 2006 Feb 10;281(6):3569-76. Epub 2005 Nov 18.

18.

CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation.

Wang Y, Nie J, Wang Y, Zhang L, Lu K, Xing G, Xie P, He F, Zhang L.

EMBO Rep. 2012 Nov 6;13(11):1004-11. doi: 10.1038/embor.2012.144. Epub 2012 Oct 2.

19.

Ubiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cells.

Wang X, Jin C, Tang Y, Tang LY, Zhang YE.

J Biol Chem. 2013 Jul 26;288(30):21784-92. doi: 10.1074/jbc.M113.472704. Epub 2013 Jun 11.

20.

Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.

Qian G, Ren Y, Zuo Y, Yuan Y, Zhao P, Wang X, Cheng Q, Liu J, Zhang L, Guo T, Liu C, Zheng H.

Biochem Biophys Res Commun. 2016 Jun 3;474(3):491-6. doi: 10.1016/j.bbrc.2016.04.135. Epub 2016 Apr 29.

PMID:
27133717

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