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Items: 1 to 20 of 206

1.

C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: effect on methotrexate-related toxicity in adult acute lymphoblastic leukaemia.

Eissa DS, Ahmed TM.

Blood Coagul Fibrinolysis. 2013 Mar;24(2):181-8. doi: 10.1097/MBC.0b013e32835b249d.

PMID:
23183238
2.

Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.

Kantar M, Kosova B, Cetingul N, Gumus S, Toroslu E, Zafer N, Topcuoglu N, Aksoylar S, Cinar M, Tetik A, Eroglu Z.

Leuk Lymphoma. 2009 Jun;50(6):912-7. doi: 10.1080/10428190902893819.

PMID:
19391036
3.

Study of the pharmacokinetic and pharmacogenetic contribution to the toxicity of high-dose methotrexate in children with acute lymphoblastic leukemia.

El-Khodary NM, El-Haggar SM, Eid MA, Ebeid EN.

Med Oncol. 2012 Sep;29(3):2053-62. doi: 10.1007/s12032-011-9997-6. Epub 2011 Jun 5.

PMID:
21644011
4.

Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetic determinants.

D'Angelo V, Ramaglia M, Iannotta A, Crisci S, Indolfi P, Francese M, Affinita MC, Pecoraro G, Napolitano A, Fusco C, Oreste M, Indolfi C, Casale F.

Cancer Chemother Pharmacol. 2011 Nov;68(5):1339-46. doi: 10.1007/s00280-011-1665-1. Epub 2011 May 18.

PMID:
21590445
5.

Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on methotrexate-induced toxicities in acute lymphoblastic leukemia: a meta-analysis.

Yang L, Hu X, Xu L.

Tumour Biol. 2012 Oct;33(5):1445-54. doi: 10.1007/s13277-012-0395-2. Epub 2012 Apr 20.

PMID:
22528943
6.

Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia.

Kałużna E, Strauss E, Zając-Spychała O, Gowin E, Świątek-Kościelna B, Nowak J, Fichna M, Mańkowski P, Januszkiewicz-Lewandowska D.

Eur J Pharmacol. 2015 Dec 15;769:93-9. doi: 10.1016/j.ejphar.2015.10.058. Epub 2015 Nov 1.

PMID:
26528799
7.

Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia.

Tantawy AA, El-Bostany EA, Adly AA, Abou El Asrar M, El-Ghouroury EA, Abdulghaffar EE.

Blood Coagul Fibrinolysis. 2010 Jan;21(1):28-34. doi: 10.1097/MBC.0b013e32833135e9. Erratum in: Blood Coagul Fibrinolysis. 2010 Mar;21(2):200.

PMID:
19923983
8.

MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients.

Chiusolo P, Reddiconto G, Farina G, Mannocci A, Fiorini A, Palladino M, La Torre G, Fianchi L, Sorà F, Laurenti L, Leone G, Sica S.

Leuk Res. 2007 Dec;31(12):1669-74. Epub 2007 May 18.

PMID:
17512587
9.

Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia.

Oh D, Kim NK, Jang MJ, Kim HC, Lee JH, Lee JA, Ahn MJ, Kim CS, Kim HS, Park S, Chio HS, Min YH; HOGS Investigators.

Anticancer Res. 2007 Sep-Oct;27(5A):3419-24.

10.

Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia.

Aplenc R, Thompson J, Han P, La M, Zhao H, Lange B, Rebbeck T.

Cancer Res. 2005 Mar 15;65(6):2482-7.

11.

Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.

Ongaro A, De Mattei M, Della Porta MG, Rigolin G, Ambrosio C, Di Raimondo F, Pellati A, Masieri FF, Caruso A, Catozzi L, Gemmati D.

Haematologica. 2009 Oct;94(10):1391-8. doi: 10.3324/haematol.2009.008326. Epub 2009 Jul 31.

12.

A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia.

Lopez-Lopez E, Martin-Guerrero I, Ballesteros J, Garcia-Orad A.

Pharmacogenomics J. 2013 Dec;13(6):498-506. doi: 10.1038/tpj.2012.44. Epub 2012 Oct 23. Review.

PMID:
23089671
13.

[Relationship between the methylenetetrahydrofolate reductase gene polymorphism and adverse reactions of high-dose methotrexate in children with acute lymphocytic leukemia].

Zheng MM, Yue LJ, Chen XW, Wen FQ, Li CG, Yang CL, Xie C, Ding H.

Zhongguo Dang Dai Er Ke Za Zhi. 2013 Mar;15(3):201-6. Chinese.

PMID:
23498762
14.

Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia.

Erčulj N, Kotnik BF, Debeljak M, Jazbec J, Dolžan V.

Leuk Lymphoma. 2012 Jun;53(6):1096-104. doi: 10.3109/10428194.2011.639880. Epub 2012 Feb 3.

PMID:
22074251
15.

High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity.

Haase R, Elsner K, Merkel N, Stiefel M, Mauz-Körholz C, Kramm CM, Körholz D.

Klin Padiatr. 2012 Apr;224(3):156-9. doi: 10.1055/s-0032-1304623. Epub 2012 Apr 18.

PMID:
22513795
16.

Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma.

Faganel Kotnik B, Grabnar I, Bohanec Grabar P, Dolžan V, Jazbec J.

Eur J Clin Pharmacol. 2011 Oct;67(10):993-1006. doi: 10.1007/s00228-011-1046-z. Epub 2011 Apr 21.

PMID:
21509569
17.

Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population.

Liu SG, Li ZG, Cui L, Gao C, Li WJ, Zhao XX.

Leuk Lymphoma. 2011 Jun;52(6):1030-40. doi: 10.3109/10428194.2011.563883. Epub 2011 May 3.

PMID:
21534867
18.

Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.

Lee YH, Song GG.

Clin Drug Investig. 2010;30(2):101-8. doi: 10.2165/11531070-000000000-00000. Review.

PMID:
20067328
19.

Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate.

van Kooten Niekerk PB, Schmiegelow K, Schroeder H.

Eur J Haematol. 2008 Nov;81(5):391-8. doi: 10.1111/j.1600-0609.2008.01128.x. Epub 2008 Aug 6.

PMID:
18691257
20.

The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue.

Chiusolo P, Giammarco S, Bellesi S, Metafuni E, Piccirillo N, De Ritis D, Marietti S, Federica S, Laurenti L, Fianchi L, Hohaus S, Giuseppe L, Sica S.

Cancer Chemother Pharmacol. 2012 Mar;69(3):691-6. doi: 10.1007/s00280-011-1751-4. Epub 2011 Oct 9.

PMID:
21984221

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