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Items: 1 to 20 of 97

1.

Novel route to chaetomellic acid A and analogues: serendipitous discovery of a more competent FTase inhibitor.

Bellesia F, Choi SR, Felluga F, Fiscaletti G, Ghelfi F, Menziani MC, Parsons AF, Poulter CD, Roncaglia F, Sabbatini M, Spinelli D.

Bioorg Med Chem. 2013 Jan 1;21(1):348-58. doi: 10.1016/j.bmc.2012.10.034. Epub 2012 Oct 29.

2.

Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues.

Singh SB, Jayasuriya H, Silverman KC, Bonfiglio CA, Williamson JM, Lingham RB.

Bioorg Med Chem. 2000 Mar;8(3):571-80.

PMID:
10732974
3.
5.

Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors.

Abuhaie CM, Ghinet A, Farce A, Dubois J, Rigo B, Bîcu E.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5887-92. doi: 10.1016/j.bmcl.2013.08.088. Epub 2013 Sep 3.

PMID:
24054122
6.
7.

Design, synthesis, and characterization of piperazinedione-based dual protein inhibitors for both farnesyltransferase and geranylgeranyltransferase-I.

Qiao Y, Gao J, Qiu Y, Wu L, Guo F, Lo KK, Li D.

Eur J Med Chem. 2011 Jun;46(6):2264-73. doi: 10.1016/j.ejmech.2011.03.007. Epub 2011 Mar 10.

PMID:
21440964
8.
9.

Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.

Bolchi C, Pallavicini M, Bernini SK, Chiodini G, Corsini A, Ferri N, Fumagalli L, Straniero V, Valoti E.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5408-12. doi: 10.1016/j.bmcl.2011.07.003. Epub 2011 Jul 13.

PMID:
21802946
10.

Synthesis and conformational analysis of peptide inhibitors of farnesyltransferase.

Byk G, Lelievre Y, Duchesne M, Clerc FF, Scherman D, Guitton JD.

Bioorg Med Chem. 1997 Jan;5(1):115-24.

PMID:
9043663
11.

Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem.

Sousa SF, Fernandes PA, Ramos MJ.

Curr Med Chem. 2008;15(15):1478-92. Review.

PMID:
18537624
12.

Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds.

Straniero V, Pallavicini M, Chiodini G, Ruggeri P, Fumagalli L, Bolchi C, Corsini A, Ferri N, Ricci C, Valoti E.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2924-7. doi: 10.1016/j.bmcl.2014.04.078. Epub 2014 Apr 30.

PMID:
24821376
13.

Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.

Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS.

Chem Biol. 2009 Feb 27;16(2):181-92. doi: 10.1016/j.chembiol.2009.01.014.

14.

Synthesis and biological activity of isopentenyl diphosphate analogues.

Scholte AA, Eubanks LM, Poulter CD, Vederas JC.

Bioorg Med Chem. 2004 Feb 15;12(4):763-70.

PMID:
14759736
15.

Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase.

Coudray L, de Figueiredo RM, Duez S, Cortial S, Dubois J.

J Enzyme Inhib Med Chem. 2009 Aug;24(4):972-85. doi: 10.1080/14756360802561196. Erratum in: J Enzyme Inhib Med Chem. 2010 Aug;25(4):596-8.

PMID:
19555171
16.

Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials.

Kohring K, Wiesner J, Altenkämper M, Sakowski J, Silber K, Hillebrecht A, Haebel P, Dahse HM, Ortmann R, Jomaa H, Klebe G, Schlitzer M.

ChemMedChem. 2008 Aug;3(8):1217-31. doi: 10.1002/cmdc.200800043.

PMID:
18470859
17.

Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.

Gilleron P, Wlodarczyk N, Houssin R, Farce A, Laconde G, Goossens JF, Lemoine A, Pommery N, Hénichart JP, Millet R.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5465-71. Epub 2007 Jul 7.

PMID:
17827015
18.

Natural products with maleic anhydride structure: nonadrides, tautomycin, chaetomellic anhydride, and other compounds.

Chen X, Zheng Y, Shen Y.

Chem Rev. 2007 May;107(5):1777-830. Epub 2007 Apr 18. Review. No abstract available.

PMID:
17439289
19.

Synthesis of oxa-bridged analogues of farnesyltransferase inhibitor RPR 115135.

Martin C, Mailliet P, Maddaluno J.

J Org Chem. 2001 Jun 1;66(11):3797-805.

PMID:
11375000
20.

Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc.

Huang CY, Stauffer TM, Strickland CL, Reader JC, Huang H, Li G, Cooper AB, Doll RJ, Ganguly AK, Baldwin JJ, Rokosz LL.

Bioorg Med Chem Lett. 2006 Feb;16(3):507-11. Epub 2005 Nov 10.

PMID:
16289818

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