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Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.

Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N.

J Proteome Res. 2013 Jan 4;12(1):282-92. doi: 10.1021/pr300565w. Epub 2012 Dec 12.


Binding of carbonic anhydrase IX to 45S rDNA genes is prevented by exportin-1 in hypoxic cells.

Sasso E, Vitale M, Monteleone F, Boffo FL, Santoriello M, Sarnataro D, Garbi C, Sabatella M, Crifò B, Paolella LA, Minopoli G, Winum JY, Zambrano N.

Biomed Res Int. 2015;2015:674920. doi: 10.1155/2015/674920. Epub 2015 Feb 22.


Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.

Ditte P, Dequiedt F, Svastova E, Hulikova A, Ohradanova-Repic A, Zatovicova M, Csaderova L, Kopacek J, Supuran CT, Pastorekova S, Pastorek J.

Cancer Res. 2011 Dec 15;71(24):7558-67. doi: 10.1158/0008-5472.CAN-11-2520. Epub 2011 Oct 28.


Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells.

Radvak P, Repic M, Svastova E, Takacova M, Csaderova L, Strnad H, Pastorek J, Pastorekova S, Kopacek J.

Oncol Rep. 2013 Mar;29(3):1147-53. doi: 10.3892/or.2013.2226. Epub 2013 Jan 4.


Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.

Svastova E, Witarski W, Csaderova L, Kosik I, Skvarkova L, Hulikova A, Zatovicova M, Barathova M, Kopacek J, Pastorek J, Pastorekova S.

J Biol Chem. 2012 Jan 27;287(5):3392-402. doi: 10.1074/jbc.M111.286062. Epub 2011 Dec 14.


Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements.

Buonanno M, Langella E, Zambrano N, Succoio M, Sasso E, Alterio V, Di Fiore A, Sandomenico A, Supuran CT, Scaloni A, Monti SM, De Simone G.

ACS Chem Biol. 2017 Jun 16;12(6):1460-1465. doi: 10.1021/acschembio.7b00055. Epub 2017 Apr 19.


Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis.

Yu SJ, Yoon JH, Lee JH, Myung SJ, Jang ES, Kwak MS, Cho EJ, Jang JJ, Kim YJ, Lee HS.

Acta Pharmacol Sin. 2011 Jul;32(7):912-20. doi: 10.1038/aps.2011.24. Epub 2011 Jun 13.


The role of carbonic anhydrase IX overexpression in kidney cancer.

Dorai T, Sawczuk IS, Pastorek J, Wiernik PH, Dutcher JP.

Eur J Cancer. 2005 Dec;41(18):2935-47.


Optimization of a novel peptide ligand targeting human carbonic anhydrase IX.

Rana S, Nissen F, Marr A, Markert A, Altmann A, Mier W, Debus J, Haberkorn U, Askoxylakis V.

PLoS One. 2012;7(5):e38279. doi: 10.1371/journal.pone.0038279. Epub 2012 May 31.


Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts.

Ditte Z, Ditte P, Labudova M, Simko V, Iuliano F, Zatovicova M, Csaderova L, Pastorekova S, Pastorek J.

BMC Cancer. 2014 May 22;14:358. doi: 10.1186/1471-2407-14-358.


Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.

Cecchi A, Hulikova A, Pastorek J, Pastoreková S, Scozzafava A, Winum JY, Montero JL, Supuran CT.

J Med Chem. 2005 Jul 28;48(15):4834-41.


Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells.

Vordermark D, Kaffer A, Riedl S, Katzer A, Flentje M.

Int J Radiat Oncol Biol Phys. 2005 Mar 15;61(4):1197-207.


Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: from biology to clinical use.

Pastorek J, Pastorekova S.

Semin Cancer Biol. 2015 Apr;31:52-64. doi: 10.1016/j.semcancer.2014.08.002. Epub 2014 Aug 10. Review.


Distinct patterns of hypoxic expression of carbonic anhydrase IX (CA IX) in human malignant glioma cell lines.

Said HM, Staab A, Hagemann C, Vince GH, Katzer A, Flentje M, Vordermark D.

J Neurooncol. 2007 Jan;81(1):27-38. Epub 2006 Aug 31.


Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

Svastová E, Hulíková A, Rafajová M, Zat'ovicová M, Gibadulinová A, Casini A, Cecchi A, Scozzafava A, Supuran CT, Pastorek J, Pastoreková S.

FEBS Lett. 2004 Nov 19;577(3):439-45.


Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia.

Ihnatko R, Kubes M, Takacova M, Sedlakova O, Sedlak J, Pastorek J, Kopacek J, Pastorekova S.

Int J Oncol. 2006 Oct;29(4):1025-33.


Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX.

Hulikova A, Zatovicova M, Svastova E, Ditte P, Brasseur R, Kettmann R, Supuran CT, Kopacek J, Pastorek J, Pastorekova S.

FEBS Lett. 2009 Nov 19;583(22):3563-8. doi: 10.1016/j.febslet.2009.10.060. Epub 2009 Oct 25.


Rapid detection of the hypoxia-regulated CA-IX and NDRG1 gene expression in different glioblastoma cells in vitro.

Said HM, Polat B, Staab A, Hagemann C, Stein S, Flentje M, Theobald M, Katzer A, Vordermark D.

Oncol Rep. 2008 Aug;20(2):413-9.


Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype.

Barathova M, Takacova M, Holotnakova T, Gibadulinova A, Ohradanova A, Zatovicova M, Hulikova A, Kopacek J, Parkkila S, Supuran CT, Pastorekova S, Pastorek J.

Br J Cancer. 2008 Jan 15;98(1):129-36. Epub 2007 Nov 20.

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