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Items: 1 to 20 of 71

1.

Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction.

Moon MJ, Park S, Kim DK, Cho EB, Hwang JI, Vaudry H, Seong JY.

Front Endocrinol (Lausanne). 2012 Nov 19;3:141. doi: 10.3389/fendo.2012.00141. eCollection 2012.

2.

Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation.

Moon MJ, Kim HY, Park S, Kim DK, Cho EB, Park CR, You DJ, Hwang JI, Kim K, Choe H, Seong JY.

J Biol Chem. 2012 Feb 3;287(6):3873-84. doi: 10.1074/jbc.M111.276808. Epub 2011 Nov 21.

3.

Molecular evolution of GPCRs: GLP1/GLP1 receptors.

Hwang JI, Yun S, Moon MJ, Park CR, Seong JY.

J Mol Endocrinol. 2014 Jun;52(3):T15-27. doi: 10.1530/JME-13-0137. Epub 2014 Mar 5. Review.

PMID:
24598200
4.

Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.

Moon MJ, Lee YN, Park S, Reyes-Alcaraz A, Hwang JI, Millar RP, Choe H, Seong JY.

J Biol Chem. 2015 Feb 27;290(9):5696-706. doi: 10.1074/jbc.M114.612606. Epub 2015 Jan 5.

5.

Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors.

Moon MJ, Kim HY, Kim SG, Park J, Choi DS, Hwang JI, Seong JY.

Mol Cells. 2010 Aug;30(2):149-54. doi: 10.1007/s10059-010-0100-5. Epub 2010 Aug 19.

6.

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.

Runge S, Thøgersen H, Madsen K, Lau J, Rudolph R.

J Biol Chem. 2008 Apr 25;283(17):11340-7. doi: 10.1074/jbc.M708740200. Epub 2008 Feb 20.

7.

Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus.

De León DD, Crutchlow MF, Ham JY, Stoffers DA.

Int J Biochem Cell Biol. 2006;38(5-6):845-59. Epub 2005 Sep 15. Review.

PMID:
16202636
8.

Potential new approaches to modifying intestinal GLP-1 secretion in patients with type 2 diabetes mellitus: focus on bile acid sequestrants.

Holst JJ, McGill MA.

Clin Drug Investig. 2012 Jan 1;32(1):1-14. doi: 10.2165/11595370-000000000-00000. Review.

PMID:
21958333
9.

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.

Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.

J Biol Chem. 2012 Feb 3;287(6):3642-58. doi: 10.1074/jbc.M111.309328. Epub 2011 Dec 6.

10.

Harnessing the therapeutic potential of glucagon-like peptide-1: a critical review.

Baggio LL, Drucker DJ.

Treat Endocrinol. 2002;1(2):117-25. Review.

PMID:
15765627
11.

Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity.

Runge S, Wulff BS, Madsen K, Bräuner-Osborne H, Knudsen LB.

Br J Pharmacol. 2003 Mar;138(5):787-94.

13.

Glucagon and glucagon-like peptide receptors as drug targets.

Estall JL, Drucker DJ.

Curr Pharm Des. 2006;12(14):1731-50. Review.

PMID:
16712485
14.

Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.

Runge S, Schimmer S, Oschmann J, Schiødt CB, Knudsen SM, Jeppesen CB, Madsen K, Lau J, Thøgersen H, Rudolph R.

Biochemistry. 2007 May 15;46(19):5830-40. Epub 2007 Apr 20.

PMID:
17444618
15.

Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor.

Willard FS, Sloop KW.

Exp Diabetes Res. 2012;2012:470851. doi: 10.1155/2012/470851. Epub 2012 May 14. Review.

16.

The physiology of glucagon-like peptide 1.

Holst JJ.

Physiol Rev. 2007 Oct;87(4):1409-39. Review.

17.

Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse.

Bahrami J, Longuet C, Baggio LL, Li K, Drucker DJ.

Gastroenterology. 2010 Sep;139(3):857-68. doi: 10.1053/j.gastro.2010.05.006. Epub 2010 Jun 11.

PMID:
20546737
18.

The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1.

López de Maturana R, Willshaw A, Kuntzsch A, Rudolph R, Donnelly D.

J Biol Chem. 2003 Mar 21;278(12):10195-200. Epub 2003 Jan 10.

19.

Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.

Runge S, Gram C, Brauner-Osborne H, Madsen K, Knudsen LB, Wulff BS.

J Biol Chem. 2003 Jul 25;278(30):28005-10. Epub 2003 Apr 29.

20.

Inhibition of glucagon secretion.

Young A.

Adv Pharmacol. 2005;52:151-71. Review.

PMID:
16492545

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