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Items: 1 to 20 of 135

1.

Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation.

Duhme N, Schweizer PA, Thomas D, Becker R, Schröter J, Barends TR, Schlichting I, Draguhn A, Bruehl C, Katus HA, Koenen M.

Eur Heart J. 2013 Sep;34(35):2768-75. doi: 10.1093/eurheartj/ehs391. Epub 2012 Nov 23.

PMID:
23178648
2.

Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia.

Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, Pras E, Dascal N, Eldar M, Glikson M.

Circulation. 2007 Jul 31;116(5):463-70. Epub 2007 Jul 23.

3.

Pacemaker channel dysfunction in a patient with sinus node disease.

Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D.

J Clin Invest. 2003 May;111(10):1537-45.

4.

The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D.

J Am Coll Cardiol. 2014 Aug 26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.

5.

A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation.

Macri V, Mahida SN, Zhang ML, Sinner MF, Dolmatova EV, Tucker NR, McLellan M, Shea MA, Milan DJ, Lunetta KL, Benjamin EJ, Ellinor PT.

Heart Rhythm. 2014 Jun;11(6):1055-1062. doi: 10.1016/j.hrthm.2014.03.002. Epub 2014 Mar 4.

6.

The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.

Netter MF, Zuzarte M, Schlichthörl G, Klöcker N, Decher N.

Cell Physiol Biochem. 2012;30(5):1227-40. doi: 10.1159/000343314. Epub 2012 Oct 15.

7.

cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control.

Schweizer PA, Duhme N, Thomas D, Becker R, Zehelein J, Draguhn A, Bruehl C, Katus HA, Koenen M.

Circ Arrhythm Electrophysiol. 2010 Oct;3(5):542-52. doi: 10.1161/CIRCEP.110.949768. Epub 2010 Aug 7.

8.

Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome.

Yeh YH, Burstein B, Qi XY, Sakabe M, Chartier D, Comtois P, Wang Z, Kuo CT, Nattel S.

Circulation. 2009 Mar 31;119(12):1576-85. doi: 10.1161/CIRCULATIONAHA.108.789677. Epub 2009 Mar 16.

9.

Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.

Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D.

N Engl J Med. 2006 Jan 12;354(2):151-7. Erratum in: N Engl J Med. 2006 Jun 8;354(23):2520.

10.

Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.

Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A.

J Biol Chem. 2004 Jun 25;279(26):27194-8. Epub 2004 Apr 30.

11.

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.

Baruscotti M, Bucchi A, Viscomi C, Mandelli G, Consalez G, Gnecchi-Rusconi T, Montano N, Casali KR, Micheloni S, Barbuti A, DiFrancesco D.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10. doi: 10.1073/pnas.1010122108. Epub 2011 Jan 10.

12.

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current.

Verkerk AO, Wilders R.

Europace. 2014 Mar;16(3):384-95. doi: 10.1093/europace/eut348. Review.

PMID:
24569893
13.

A KCNQ1 mutation causes age-dependant bradycardia and persistent atrial fibrillation.

Ki CS, Jung CL, Kim HJ, Baek KH, Park SJ, On YK, Kim KS, Noh SJ, Youm JB, Kim JS, Cho H.

Pflugers Arch. 2014 Mar;466(3):529-40. doi: 10.1007/s00424-013-1337-6. Epub 2013 Aug 30.

PMID:
23989646
14.
15.

Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.

D'Souza A, Pearman CM, Wang Y, Nakao S, Logantha SJRJ, Cox C, Bennett H, Zhang Y, Johnsen AB, Linscheid N, Poulsen PC, Elliott J, Coulson J, McPhee J, Robertson A, da Costa Martins PA, Kitmitto A, Wisløff U, Cartwright EJ, Monfredi O, Lundby A, Dobrzynski H, Oceandy D, Morris GM, Boyett MR.

Circ Res. 2017 Oct 13;121(9):1058-1068. doi: 10.1161/CIRCRESAHA.117.311607. Epub 2017 Aug 17.

16.

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation.

Li YD, Hong YF, Yusufuaji Y, Tang BP, Zhou XH, Xu GJ, Li JX, Sun L, Zhang JH, Xin Q, Xiong J, Ji YT, Zhang Y.

Mol Med Rep. 2015 Sep;12(3):3243-8. doi: 10.3892/mmr.2015.3831. Epub 2015 May 25.

17.

A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.

Laish-Farkash A, Glikson M, Brass D, Marek-Yagel D, Pras E, Dascal N, Antzelevitch C, Nof E, Reznik H, Eldar M, Luria D.

J Cardiovasc Electrophysiol. 2010 Dec;21(12):1365-72. doi: 10.1111/j.1540-8167.2010.01844.x.

18.

HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy.

Milano A, Vermeer AM, Lodder EM, Barc J, Verkerk AO, Postma AV, van der Bilt IA, Baars MJ, van Haelst PL, Caliskan K, Hoedemaekers YM, Le Scouarnec S, Redon R, Pinto YM, Christiaans I, Wilde AA, Bezzina CR.

J Am Coll Cardiol. 2014 Aug 26;64(8):745-56. doi: 10.1016/j.jacc.2014.05.045.

19.

An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia.

Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB.

J Cardiovasc Electrophysiol. 2013 Sep;24(9):1021-7. doi: 10.1111/jce.12163. Epub 2013 Apr 30.

20.

Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation.

Li YD, Hong YF, Zhang Y, Zhou XH, Ji YT, Li HL, Hu GJ, Li JX, Sun L, Zhang JH, Xin Q, Yusufuaji Y, Xiong J, Tang BP.

Med Sci Monit. 2014 Nov 14;20:2292-7. doi: 10.12659/MSM.892505.

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