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Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia.

Volanakis EJ, Boothby MR, Sherr CJ.

Exp Hematol. 2013 Apr;41(4):377-86. doi: 10.1016/j.exphem.2012.11.006. Epub 2012 Nov 23.


Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia.

Volanakis EJ, Williams RT, Sherr CJ.

Blood. 2009 Nov 12;114(20):4451-9. doi: 10.1182/blood-2009-07-233346. Epub 2009 Sep 16.


Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.

Treanor LM, Volanakis EJ, Zhou S, Lu T, Sherr CJ, Sorrentino BP.

Blood. 2011 May 19;117(20):5453-62. doi: 10.1182/blood-2010-09-309831. Epub 2011 Mar 22.


Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.

Medyouf H, Gao X, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz KR, Pflumio F, You MJ, Weng AP.

Blood. 2010 Feb 11;115(6):1175-84. doi: 10.1182/blood-2009-04-214718. Epub 2009 Dec 11.


The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.

Durinck K, Wallaert A, Van de Walle I, Van Loocke W, Volders PJ, Vanhauwaert S, Geerdens E, Benoit Y, Van Roy N, Poppe B, Soulier J, Cools J, Mestdagh P, Vandesompele J, Rondou P, Van Vlierberghe P, Taghon T, Speleman F.

Haematologica. 2014 Dec;99(12):1808-16. doi: 10.3324/haematol.2014.115683. Epub 2014 Oct 24.


p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice.

Shank-Calvo JA, Draheim K, Bhasin M, Kelliher MA.

Oncogene. 2006 May 18;25(21):3023-31.


Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages.

Randle DH, Zindy F, Sherr CJ, Roussel MF.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9654-9. Epub 2001 Jul 31.


Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.

Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT.

Br J Haematol. 2014 Jul;166(1):84-90. doi: 10.1111/bjh.12851. Epub 2014 Apr 2.


Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.

Kong G, Du J, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J.

J Biol Chem. 2013 Jun 21;288(25):18219-27. doi: 10.1074/jbc.M113.475376. Epub 2013 May 14. Erratum in: J Biol Chem. 2013 Dec 27;288(52):37368.


High-risk acute lymphoblastic leukemia cells with bcr-abl and INK4A/ARF mutations retain susceptibility to alloreactive T cells.

Young FM, Campbell A, Emo KL, Jansson J, Wang PY, Jordan CT, Mullen CA.

Biol Blood Marrow Transplant. 2008 Jun;14(6):622-30. doi: 10.1016/j.bbmt.2008.02.015. Epub 2008 Apr 14.


Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P.

Blood. 2010 Dec 16;116(25):5443-54. doi: 10.1182/blood-2010-05-286658. Epub 2010 Sep 9.


Consistent inactivation of p19(Arf) but not p15(Ink4b) in murine myeloid cells transformed in vivo by deregulated c-Myc.

Haviernik P, Schmidt M, Hu X, Wolff L.

Oncogene. 2003 Mar 20;22(11):1600-10.


p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.

Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A.

Blood. 2007 Oct 1;110(7):2610-9. Epub 2007 May 16.


Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines.

Park YB, Park MJ, Kimura K, Shimizu K, Lee SH, Yokota J.

Cancer Genet Cytogenet. 2002 Mar;133(2):105-11.


Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

Aste-Am├ęzaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, Huang L, Vitelli S, Vo KT, Haytko P, Zhao JZ, Baleydier F, L'Heureux S, Wang H, Gordon WR, Thoryk E, Andrawes MB, Tiyanont K, Stegmaier K, Roti G, Ross KN, Franlin LL, Wang H, Wang F, Chastain M, Bett AJ, Audoly LP, Aster JC, Blacklow SC, Huber HE.

PLoS One. 2010 Feb 8;5(2):e9094. doi: 10.1371/journal.pone.0009094.


Developmental strategies for evasion of Arf tumor suppression.

Volanakis EJ, Sherr CJ.

Cell Cycle. 2010 Jan 1;9(1):14-5. Epub 2010 Jan 21. No abstract available.


Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.

Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K.

Genes Dev. 2008 Nov 15;22(22):3115-20. doi: 10.1101/gad.1715808.


p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis.

Sachs Z, Sharpless NE, DePinho RA, Rosenberg N.

J Virol. 2004 Apr;78(7):3304-11.


The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA.

Oncogene. 2004 Jan 15;23(2):379-85.


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