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Hypomethylation of the IL17RC promoter associates with age-related macular degeneration.

Wei L, Liu B, Tuo J, Shen D, Chen P, Li Z, Liu X, Ni J, Dagur P, Sen HN, Jawad S, Ling D, Park S, Chakrabarty S, Meyerle C, Agron E, Ferris FL 3rd, Chew EY, McCoy JP, Blum E, Francis PJ, Klein ML, Guymer RH, Baird PN, Chan CC, Nussenblatt RB.

Cell Rep. 2012 Nov 29;2(5):1151-8. doi: 10.1016/j.celrep.2012.10.013.


Hypomethylation of the IL17RC promoter in peripheral blood leukocytes is not a hallmark of age-related macular degeneration.

Oliver VF, Franchina M, Jaffe AE, Branham KE, Othman M, Heckenlively JR, Swaroop A, Campochiaro B, Vote BJ, Craig JE, Saffery R, Mackey DA, Qian J, Zack DJ, Hewitt AW, Merbs SL.

Cell Rep. 2013 Dec 26;5(6):1527-35. doi: 10.1016/j.celrep.2013.11.042.


Differential DNA methylation identified in the blood and retina of AMD patients.

Oliver VF, Jaffe AE, Song J, Wang G, Zhang P, Branham KE, Swaroop A, Eberhart CG, Zack DJ, Qian J, Merbs SL.

Epigenetics. 2015;10(8):698-707. doi: 10.1080/15592294.2015.1060388.


Age-related macular degeneration and DNA methylation.

Baird PN, Wei L.

Epigenomics. 2013 Jun;5(3):239-41. doi: 10.2217/epi.13.19. No abstract available.


1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey--a plausible explanation for the influence of vitamin D on age-related macular degeneration?

Pahl L, Schubert S, Skawran B, Sandbothe M, Schmidtke J, Stuhrmann M.

Exp Eye Res. 2013 Nov;116:234-9. doi: 10.1016/j.exer.2013.09.012.


Mechanisms of age-related macular degeneration.

Ambati J, Fowler BJ.

Neuron. 2012 Jul 12;75(1):26-39. doi: 10.1016/j.neuron.2012.06.018. Review.


DNA methylation is associated with altered gene expression in AMD.

Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, Hunter AK, Dezoeten E, Dunaief JL.

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2089-105. doi: 10.1167/iovs.11-8449.


Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.

Ardeljan D, Wang Y, Park S, Shen D, Chu XK, Yu CR, Abu-Asab M, Tuo J, Eberhart CG, Olsen TW, Mullins RF, White G, Wadsworth S, Scaria A, Chan CC.

PLoS One. 2014 Apr 29;9(4):e95900. doi: 10.1371/journal.pone.0095900.


TCCR/WSX-1 is a novel angiogenic factor in age-related macular degeneration.

Sung HJ, Han JI, Lee JW, Uhm KB, Heo K.

Mol Vis. 2012;18:234-40.


Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration.

Chan CC, Tuo J, Bojanowski CM, Csaky KG, Green WR.

Histol Histopathol. 2005 Jul;20(3):857-63.


Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration.

Liu B, Wei L, Meyerle C, Tuo J, Sen HN, Li Z, Chakrabarty S, Agron E, Chan CC, Klein ML, Chew E, Ferris F, Nussenblatt RB.

J Transl Med. 2011 Jul 15;9:1-12. doi: 10.1186/1479-5876-9-111.


Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models.

Hall JB, Cooke Bailey JN, Hoffman JD, Pericak-Vance MA, Scott WK, Kovach JL, Schwartz SG, Agarwal A, Brantley MA Jr, Haines JL, Bush WS.

BMC Bioinformatics. 2015 Oct 14;16:329. doi: 10.1186/s12859-015-0760-4.


The ERCC6 gene and age-related macular degeneration.

Baas DC, Despriet DD, Gorgels TG, Bergeron-Sawitzke J, Uitterlinden AG, Hofman A, van Duijn CM, Merriam JE, Smith RT, Barile GR, ten Brink JB, Vingerling JR, Klaver CC, Allikmets R, Dean M, Bergen AA.

PLoS One. 2010 Nov 1;5(11):e13786. doi: 10.1371/journal.pone.0013786.


The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples.

Tuo J, Ross RJ, Reed GF, Yan Q, Wang JJ, Bojanowski CM, Chew EY, Feng X, Olsen TW, Ferris FL 3rd, Mitchell P, Chan CC.

Ophthalmology. 2008 Nov;115(11):1891-8. doi: 10.1016/j.ophtha.2008.05.021.


Molecular pathology of age-related macular degeneration.

Ding X, Patel M, Chan CC.

Prog Retin Eye Res. 2009 Jan;28(1):1-18. doi: 10.1016/j.preteyeres.2008.10.001. Review.


The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration.

Tuo J, Smith BC, Bojanowski CM, Meleth AD, Gery I, Csaky KG, Chew EY, Chan CC.

FASEB J. 2004 Aug;18(11):1297-9.


The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences.

Seddon JM, Cote J, Page WF, Aggen SH, Neale MC.

Arch Ophthalmol. 2005 Mar;123(3):321-7.


Genetic variants of interleukin 17A are functionally associated with increased risk of age-related macular degeneration.

Zhang S, Liu Y, Lu S, Cai X.

Inflammation. 2015 Apr;38(2):658-63. doi: 10.1007/s10753-014-9973-3.


A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.

Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K.

Science. 2006 Nov 10;314(5801):992-3.


The molecular genetic basis of age-related macular degeneration: an overview.

Katta S, Kaur I, Chakrabarti S.

J Genet. 2009 Dec;88(4):425-49. Review.

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