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Items: 1 to 20 of 104

1.

Mutagenesis and modeling to predict structural and functional characteristics of the Staphylococcus aureus MepA multidrug efflux pump.

Schindler BD, Patel D, Seo SM, Kaatz GW.

J Bacteriol. 2013 Feb;195(3):523-33. doi: 10.1128/JB.01679-12. Epub 2012 Nov 21.

2.

Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene.

Schindler BD, Seo SM, Jacinto PL, Kumaraswami M, Birukou I, Brennan RG, Kaatz GW.

J Bacteriol. 2013 Aug;195(16):3651-62. doi: 10.1128/JB.00565-13. Epub 2013 Jun 7.

3.
4.

The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.

Birukou I, Tonthat NK, Seo SM, Schindler BD, Kaatz GW, Brennan RG.

MBio. 2013 Aug 27;4(5):e00528-13. doi: 10.1128/mBio.00528-13.

5.

Clonal relatedness is a predictor of spontaneous multidrug efflux pump gene overexpression in Staphylococcus aureus.

Schindler BD, Jacinto PL, Buensalido JA, Seo SM, Kaatz GW.

Int J Antimicrob Agents. 2015 May;45(5):464-70. doi: 10.1016/j.ijantimicag.2014.11.007. Epub 2014 Dec 10.

PMID:
25548027
6.

From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.

Pieroni M, Dimovska M, Brincat JP, Sabatini S, Carosati E, Massari S, Kaatz GW, Fravolini A.

J Med Chem. 2010 Jun 10;53(11):4466-80. doi: 10.1021/jm1003304. Erratum in: J Med Chem. 2011 Mar 10;54(5):1537.

PMID:
20446747
7.

Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus.

DeMarco CE, Cushing LA, Frempong-Manso E, Seo SM, Jaravaza TA, Kaatz GW.

Antimicrob Agents Chemother. 2007 Sep;51(9):3235-9. Epub 2007 Jun 18.

8.
9.

Multidrug efflux pump overexpression in Staphylococcus aureus after single and multiple in vitro exposures to biocides and dyes.

Huet AA, Raygada JL, Mendiratta K, Seo SM, Kaatz GW.

Microbiology. 2008 Oct;154(Pt 10):3144-53. doi: 10.1099/mic.0.2008/021188-0.

PMID:
18832320
10.

A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.

McAleese F, Petersen P, Ruzin A, Dunman PM, Murphy E, Projan SJ, Bradford PA.

Antimicrob Agents Chemother. 2005 May;49(5):1865-71.

11.

Inability of a reserpine-based screen to identify strains overexpressing efflux pump genes in clinical isolates of Staphylococcus aureus.

Frempong-Manso E, Raygada JL, DeMarco CE, Seo SM, Kaatz GW.

Int J Antimicrob Agents. 2009 Apr;33(4):360-3. doi: 10.1016/j.ijantimicag.2008.10.016. Epub 2008 Dec 21.

PMID:
19097759
12.

Efflux-mediated response of Staphylococcus aureus exposed to ethidium bromide.

Couto I, Costa SS, Viveiros M, Martins M, Amaral L.

J Antimicrob Chemother. 2008 Sep;62(3):504-13. doi: 10.1093/jac/dkn217. Epub 2008 May 28.

PMID:
18511413
13.

Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.

Kumaraswami M, Schuman JT, Seo SM, Kaatz GW, Brennan RG.

Nucleic Acids Res. 2009 Mar;37(4):1211-24. doi: 10.1093/nar/gkn1046. Epub 2009 Jan 7.

14.

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.

Opperman TJ, Williams JD, Houseweart C, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL.

Bioorg Med Chem. 2010 Mar 15;18(6):2123-30. doi: 10.1016/j.bmc.2010.02.005. Epub 2010 Feb 10.

PMID:
20188576
15.

Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.

Sabatini S, Gosetto F, Iraci N, Barreca ML, Massari S, Sancineto L, Manfroni G, Tabarrini O, Dimovska M, Kaatz GW, Cecchetti V.

J Med Chem. 2013 Jun 27;56(12):4975-89. doi: 10.1021/jm400262a. Epub 2013 Jun 13.

PMID:
23710549
16.

Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus.

Schindler BD, Seo SM, Birukou I, Brennan RG, Kaatz GW.

J Bacteriol. 2015 Mar;197(6):1104-14. doi: 10.1128/JB.02558-14. Epub 2015 Jan 12.

17.

Expression of multidrug resistance efflux pump genes in clinical and environmental isolates of Staphylococcus aureus.

Kosmidis C, Schindler BD, Jacinto PL, Patel D, Bains K, Seo SM, Kaatz GW.

Int J Antimicrob Agents. 2012 Sep;40(3):204-9. doi: 10.1016/j.ijantimicag.2012.04.014. Epub 2012 Jul 4.

PMID:
22766161
18.

Substrate binding to the multidrug transporter MepA.

Banchs C, Poulos S, Nimjareansuk WS, Joo YE, Faham S.

Biochim Biophys Acta. 2014 Oct;1838(10):2539-46. doi: 10.1016/j.bbamem.2014.06.013. Epub 2014 Jun 23.

19.

Dithiazole thione derivative as competitive NorA efflux pump inhibitor to curtail multi drug resistant clinical isolate of MRSA in a zebrafish infection model.

Lowrence RC, Raman T, Makala HV, Ulaganathan V, Subramaniapillai SG, Kuppuswamy AA, Mani A, Chittoor Neelakantan S, Nagarajan S.

Appl Microbiol Biotechnol. 2016 Nov;100(21):9265-9281. Epub 2016 Aug 16.

PMID:
27531512
20.

Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA.

Hassan KA, Galea M, Wu J, Mitchell BA, Skurray RA, Brown MH.

FEMS Microbiol Lett. 2006 Oct;263(1):76-85.

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