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Items: 1 to 20 of 113


Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression.

Goldsmith EC, Bradshaw AD, Spinale FG.

Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C393-402. doi: 10.1152/ajpcell.00347.2012. Epub 2012 Nov 21. Review.


Cardiac extracellular matrix remodeling: fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC).

McCurdy S, Baicu CF, Heymans S, Bradshaw AD.

J Mol Cell Cardiol. 2010 Mar;48(3):544-9. doi: 10.1016/j.yjmcc.2009.06.018. Epub 2009 Jul 3. Review.


Membrane-associated matrix proteolysis and heart failure.

Spinale FG, Janicki JS, Zile MR.

Circ Res. 2013 Jan 4;112(1):195-208. doi: 10.1161/CIRCRESAHA.112.266882. Review.


Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing.

Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Boggs J, Lacy JM, Zile MR.

Circulation. 2009 Jan 20;119(2):269-80. doi: 10.1161/CIRCULATIONAHA.108.773424. Epub 2008 Dec 31.


Temporal and Molecular Analyses of Cardiac Extracellular Matrix Remodeling following Pressure Overload in Adiponectin Deficient Mice.

Dadson K, Turdi S, Boo S, Hinz B, Sweeney G.

PLoS One. 2015 Apr 24;10(4):e0121049. doi: 10.1371/journal.pone.0121049. eCollection 2015.


Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing.

Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Bonnema DD, Zile MR.

Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H614-22. doi: 10.1152/ajpheart.00474.2009. Epub 2009 Dec 11.


Time course of right ventricular pressure-overload induced myocardial fibrosis: relationship to changes in fibroblast postsynthetic procollagen processing.

Baicu CF, Li J, Zhang Y, Kasiganesan H, Cooper G 4th, Zile MR, Bradshaw AD.

Am J Physiol Heart Circ Physiol. 2012 Nov 1;303(9):H1128-34. doi: 10.1152/ajpheart.00482.2012. Epub 2012 Aug 31.


Lack of tissue inhibitor of metalloproteinases 2 leads to exacerbated left ventricular dysfunction and adverse extracellular matrix remodeling in response to biomechanical stress.

Kandalam V, Basu R, Moore L, Fan D, Wang X, Jaworski DM, Oudit GY, Kassiri Z.

Circulation. 2011 Nov 8;124(19):2094-105. doi: 10.1161/CIRCULATIONAHA.111.030338. Epub 2011 Oct 10.


TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation.

Kandalam V, Basu R, Abraham T, Wang X, Soloway PD, Jaworski DM, Oudit GY, Kassiri Z.

Circ Res. 2010 Mar 5;106(4):796-808. doi: 10.1161/CIRCRESAHA.109.209189. Epub 2010 Jan 7.


The extracellular matrix modulates fibroblast phenotype and function in the infarcted myocardium.

Dobaczewski M, de Haan JJ, Frangogiannis NG.

J Cardiovasc Transl Res. 2012 Dec;5(6):837-47. doi: 10.1007/s12265-012-9406-3. Epub 2012 Sep 7. Review.


Syndecans in heart fibrosis.

Lunde IG, Herum KM, Carlson CC, Christensen G.

Cell Tissue Res. 2016 Sep;365(3):539-52. doi: 10.1007/s00441-016-2454-2. Epub 2016 Jul 14. Review.


Human cardiac fibroblast extracellular matrix remodeling: dual effects of tissue inhibitor of metalloproteinase-2.

Ngu JM, Teng G, Meijndert HC, Mewhort HE, Turnbull JD, Stetler-Stevenson WG, Fedak PW.

Cardiovasc Pathol. 2014 Nov-Dec;23(6):335-43. doi: 10.1016/j.carpath.2014.06.003. Epub 2014 Jun 21.


Alterations in cultured myocardial fibroblast function following the development of left ventricular failure.

Flack EC, Lindsey ML, Squires CE, Kaplan BS, Stroud RE, Clark LL, Escobar PG, Yarbrough WM, Spinale FG.

J Mol Cell Cardiol. 2006 Apr;40(4):474-83. Epub 2006 Mar 6.


Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis.

MacKenna D, Summerour SR, Villarreal FJ.

Cardiovasc Res. 2000 May;46(2):257-63. Review.


Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation.

El Hajj EC, El Hajj MC, Voloshenyuk TG, Mouton AJ, Khoutorova E, Molina PE, Gilpin NW, Gardner JD.

Alcohol Clin Exp Res. 2014 Feb;38(2):448-56. doi: 10.1111/acer.12239. Epub 2013 Aug 19.


MMP induction and inhibition in myocardial infarction.

Lindsey ML.

Heart Fail Rev. 2004 Jan;9(1):7-19. Review.


Cardiac remodeling by fibrous tissue after infarction in rats.

Sun Y, Zhang JQ, Zhang J, Lamparter S.

J Lab Clin Med. 2000 Apr;135(4):316-23.


SPARC mediates early extracellular matrix remodeling following myocardial infarction.

McCurdy SM, Dai Q, Zhang J, Zamilpa R, Ramirez TA, Dayah T, Nguyen N, Jin YF, Bradshaw AD, Lindsey ML.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H497-505. doi: 10.1152/ajpheart.01070.2010. Epub 2011 May 20.


Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.

Miller CL, Cai Y, Oikawa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C.

Basic Res Cardiol. 2011 Nov;106(6):1023-39. doi: 10.1007/s00395-011-0228-2. Epub 2011 Oct 20.

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