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Items: 1 to 20 of 120

1.

Inhibition of hedgehog signaling attenuates carcinogenesis in vitro and increases necrosis of cholangiocellular carcinoma.

El Khatib M, Kalnytska A, Palagani V, Kossatz U, Manns MP, Malek NP, Wilkens L, Plentz RR.

Hepatology. 2013 Mar;57(3):1035-45. doi: 10.1002/hep.26147. Epub 2013 Jan 25. Erratum in: Hepatology. 2014 Aug;60(2):771.

PMID:
23172661
2.

Hedgehog pathway as a potential treatment target in human cholangiocarcinoma.

Riedlinger D, Bahra M, Boas-Knoop S, Lippert S, Bradtmöller M, Guse K, Seehofer D, Bova R, Sauer IM, Neuhaus P, Koch A, Kamphues C.

J Hepatobiliary Pancreat Sci. 2014 Aug;21(8):607-15. doi: 10.1002/jhbp.107. Epub 2014 Apr 15.

PMID:
24733827
3.

The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma.

Tang L, Tan YX, Jiang BG, Pan YF, Li SX, Yang GZ, Wang M, Wang Q, Zhang J, Zhou WP, Dong LW, Wang HY.

Clin Cancer Res. 2013 Apr 15;19(8):2014-24. doi: 10.1158/1078-0432.CCR-12-0349. Epub 2013 Mar 14.

4.

Hedgehog signaling between cancer cells and hepatic stellate cells in promoting cholangiocarcinoma.

Kim Y, Kim MO, Shin JS, Park SH, Kim SB, Kim J, Park SC, Han CJ, Ryu JK, Yoon YB, Kim YT.

Ann Surg Oncol. 2014 Aug;21(8):2684-98. doi: 10.1245/s10434-014-3531-y. Epub 2014 Mar 31.

PMID:
24682719
5.

Gefitinib and gemcitabine coordinately inhibited the proliferation of cholangiocarcinoma cells.

Nakajima Y, Takagi H, Kakizaki S, Horiguchi N, Sato K, Sunaga N, Mori M.

Anticancer Res. 2012 Dec;32(12):5251-62.

PMID:
23225424
6.

Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.

Duan F, Lin M, Li C, Ding X, Qian G, Zhang H, Ge S, Fan X, Li J.

Cancer Biol Ther. 2014 May;15(5):544-59. doi: 10.4161/cbt.28157. Epub 2014 Mar 11.

7.

Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions.

Xiao C, Ogle SA, Schumacher MA, Schilling N, Tokhunts RA, Orr-Asman MA, Miller ML, Robbins DJ, Hollande F, Zavros Y.

Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1252-65. doi: 10.1152/ajpgi.00512.2009. Epub 2010 Sep 16.

8.

FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling.

Lu Z, Wang J, Zheng T, Liang Y, Yin D, Song R, Pei T, Pan S, Jiang H, Liu L.

BMC Cancer. 2014 Oct 25;14:783. doi: 10.1186/1471-2407-14-783.

9.

Role of hedgehog signaling in ovarian cancer.

Bhattacharya R, Kwon J, Ali B, Wang E, Patra S, Shridhar V, Mukherjee P.

Clin Cancer Res. 2008 Dec 1;14(23):7659-66. doi: 10.1158/1078-0432.CCR-08-1414.

10.

The H4 histamine receptor agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of epithelial mesenchymal transition and tumor metastasis.

Meng F, Han Y, Staloch D, Francis T, Stokes A, Francis H.

Hepatology. 2011 Nov;54(5):1718-28. doi: 10.1002/hep.24573.

PMID:
21793031
11.

Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma.

Barat S, Bozko P, Chen X, Scholta T, Hanert F, Götze J, Malek NP, Wilkens L, Plentz RR.

Mol Carcinog. 2016 Dec;55(12):2037-2050. doi: 10.1002/mc.22449. Epub 2016 Jan 12.

PMID:
26757360
12.

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.

Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, Matsui W, Piccirillo S, Vescovi AL, DiMeco F, Olivi A, Eberhart CG.

Stem Cells. 2007 Oct;25(10):2524-33. Epub 2007 Jul 12.

13.

Selective release of a cyclopamine glucuronide prodrug toward stem-like cancer cell inhibition in glioblastoma.

Balbous A, Renoux B, Cortes U, Milin S, Guilloteau K, Legigan T, Rivet P, Boissonnade O, Martin S, Tripiana C, Wager M, Bensadoun RJ, Papot S, Karayan-Tapon L.

Mol Cancer Ther. 2014 Sep;13(9):2159-69. doi: 10.1158/1535-7163.MCT-13-1038. Epub 2014 Jul 22.

14.

Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma.

Tsai CL, Hsu FM, Tzen KY, Liu WL, Cheng AL, Cheng JC.

J Gastroenterol Hepatol. 2015 Aug;30(8):1317-24. doi: 10.1111/jgh.12931.

PMID:
25682950
15.

Cyclopamine inhibition of the sonic hedgehog pathway in the stomach requires concomitant acid inhibition.

El-Zaatari M, Grabowska AM, McKenzie AJ, Powe DG, Scotting PJ, Watson SA.

Regul Pept. 2008 Feb 7;146(1-3):131-9. Epub 2007 Sep 19.

PMID:
17996964
16.

The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.

Williamson AJ, Doscas ME, Ye J, Heiden KB, Xing M, Li Y, Prinz RA, Xu X.

Oncotarget. 2016 Mar 1;7(9):10472-85. doi: 10.18632/oncotarget.7228.

17.

Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer.

Song Z, Yue W, Wei B, Wang N, Li T, Guan L, Shi S, Zeng Q, Pei X, Chen L.

PLoS One. 2011 Mar 4;6(3):e17687. doi: 10.1371/journal.pone.0017687.

18.

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.

Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, Karikari C, Alvarez H, Iacobuzio-Donahue C, Jimeno A, Gabrielson KL, Matsui W, Maitra A.

Cancer Res. 2007 Mar 1;67(5):2187-96.

19.

Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.

Wutka A, Palagani V, Barat S, Chen X, El Khatib M, Götze J, Belahmer H, Zender S, Bozko P, Malek NP, Plentz RR.

PLoS One. 2014 Apr 18;9(4):e95605. doi: 10.1371/journal.pone.0095605. eCollection 2014. Erratum in: PLoS One. 2016;11(9):e0162673.

20.

Hedgehog signaling in the murine melanoma microenvironment.

Geng L, Cuneo KC, Cooper MK, Wang H, Sekhar K, Fu A, Hallahan DE.

Angiogenesis. 2007;10(4):259-67. Epub 2007 Aug 31.

PMID:
17762973

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